Tualang honey effects on high cholesterol diet induced nonalcoholic steatohepatitis in an animal model

Aim: This study aimed to examine the effects of tualang honey against the high cholesterol diet induced biochemical and histological changes in the liver and pancreas. Methods: Female Sprague-Dawley rats were used, where the control group (n = 5) was fed with commercial rat pellet; the high choleste...

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Main Authors:	Hamad Mohamed, Zenab B., Hamad Alfarisi, Hamad Abdulsalam, Abdullah, Nor Zamzila, Harun, Norra, Muhammad, Naznin, Abdul Rahim, Roslina
Format:	Article
Language:	English
Published:	World Journal Of Pharmacy And Pharmaceutical Sciences 2018
Subjects:	QP Physiology R Medicine (General) RB Pathology RC Internal medicine RC648 Specialties of Internal Medicine-Diseases of The Endocrine Glands. Clinical Endocrinology RC803 Specialties of Internal Medicine-Diseases of The Digestive System. Gastroenterology RD Surgery
Online Access:	http://irep.iium.edu.my/61863/ http://irep.iium.edu.my/61863/ http://irep.iium.edu.my/61863/1/article_wjpps_1517713076.pdf

id	iium-61863
recordtype	eprints
spelling	iium-618632018-06-10T04:33:55Z http://irep.iium.edu.my/61863/ Tualang honey effects on high cholesterol diet induced nonalcoholic steatohepatitis in an animal model Hamad Mohamed, Zenab B. Hamad Alfarisi, Hamad Abdulsalam Abdullah, Nor Zamzila Harun, Norra Muhammad, Naznin Abdul Rahim, Roslina QP Physiology R Medicine (General) RB Pathology RC Internal medicine RC648 Specialties of Internal Medicine-Diseases of The Endocrine Glands. Clinical Endocrinology RC803 Specialties of Internal Medicine-Diseases of The Digestive System. Gastroenterology RD Surgery Aim: This study aimed to examine the effects of tualang honey against the high cholesterol diet induced biochemical and histological changes in the liver and pancreas. Methods: Female Sprague-Dawley rats were used, where the control group (n = 5) was fed with commercial rat pellet; the high cholesterol diet (HCD) group (n= 5) was given 12% cholesterol diet; while the HCD with tualang honey (HCD+TH) group (n =5) was fed with 12% cholesterol diet with daily 1.4 g/kg/day of tualang honey. Blood biochemical analysis were analysed at 1 week and 6 weeks. The liver and pancreas tissues were harvested at the end of 6 weeks for histological examination. Results: The cholesterol diet induction resulted in dyslipidaemia and abnormal liver function. The HCD+TH group have shown an increase in total cholesterol, LDL-c, ALP levels and decreased TG, HDL-c and AST levels significantly at the end of 6 weeks compared to HCD group. The mean plasma glucose level was elevated at 1 week in the HCD group. Plasma insulin levels were higher in HCD+TH group at both 1 and 6 weeks. The HOMA-IR was also higher at 1 week in the HCD+TH group. The liver histology of both HCD and HCD+TH groups showed steatohepatitis with minimal hepatocyte degeneration while the pancreatic sections revealed no abnormalities. Conclusion: The cholesterol diet of 6 weeks duration in this study did induce some features of NASH with dyslipidaemia with abnormal liver profile. Low dose of Tualang honey supplementation exhibited no effect on dyslipidaemia and histopathological changes. World Journal Of Pharmacy And Pharmaceutical Sciences 2018-02 Article PeerReviewed application/pdf en http://irep.iium.edu.my/61863/1/article_wjpps_1517713076.pdf Hamad Mohamed, Zenab B. and Hamad Alfarisi, Hamad Abdulsalam and Abdullah, Nor Zamzila and Harun, Norra and Muhammad, Naznin and Abdul Rahim, Roslina (2018) Tualang honey effects on high cholesterol diet induced nonalcoholic steatohepatitis in an animal model. World Journal Of Pharmacy And Pharmaceutical Sciences, 7 (2). pp. 1383-1396. ISSN 2278-4357 http://www.wjpps.com/wjpps_controller/abstract_id/8549
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QP Physiology R Medicine (General) RB Pathology RC Internal medicine RC648 Specialties of Internal Medicine-Diseases of The Endocrine Glands. Clinical Endocrinology RC803 Specialties of Internal Medicine-Diseases of The Digestive System. Gastroenterology RD Surgery
spellingShingle	QP Physiology R Medicine (General) RB Pathology RC Internal medicine RC648 Specialties of Internal Medicine-Diseases of The Endocrine Glands. Clinical Endocrinology RC803 Specialties of Internal Medicine-Diseases of The Digestive System. Gastroenterology RD Surgery Hamad Mohamed, Zenab B. Hamad Alfarisi, Hamad Abdulsalam Abdullah, Nor Zamzila Harun, Norra Muhammad, Naznin Abdul Rahim, Roslina Tualang honey effects on high cholesterol diet induced nonalcoholic steatohepatitis in an animal model
description	Aim: This study aimed to examine the effects of tualang honey against the high cholesterol diet induced biochemical and histological changes in the liver and pancreas. Methods: Female Sprague-Dawley rats were used, where the control group (n = 5) was fed with commercial rat pellet; the high cholesterol diet (HCD) group (n= 5) was given 12% cholesterol diet; while the HCD with tualang honey (HCD+TH) group (n =5) was fed with 12% cholesterol diet with daily 1.4 g/kg/day of tualang honey. Blood biochemical analysis were analysed at 1 week and 6 weeks. The liver and pancreas tissues were harvested at the end of 6 weeks for histological examination. Results: The cholesterol diet induction resulted in dyslipidaemia and abnormal liver function. The HCD+TH group have shown an increase in total cholesterol, LDL-c, ALP levels and decreased TG, HDL-c and AST levels significantly at the end of 6 weeks compared to HCD group. The mean plasma glucose level was elevated at 1 week in the HCD group. Plasma insulin levels were higher in HCD+TH group at both 1 and 6 weeks. The HOMA-IR was also higher at 1 week in the HCD+TH group. The liver histology of both HCD and HCD+TH groups showed steatohepatitis with minimal hepatocyte degeneration while the pancreatic sections revealed no abnormalities. Conclusion: The cholesterol diet of 6 weeks duration in this study did induce some features of NASH with dyslipidaemia with abnormal liver profile. Low dose of Tualang honey supplementation exhibited no effect on dyslipidaemia and histopathological changes.
format	Article
author	Hamad Mohamed, Zenab B. Hamad Alfarisi, Hamad Abdulsalam Abdullah, Nor Zamzila Harun, Norra Muhammad, Naznin Abdul Rahim, Roslina
author_facet	Hamad Mohamed, Zenab B. Hamad Alfarisi, Hamad Abdulsalam Abdullah, Nor Zamzila Harun, Norra Muhammad, Naznin Abdul Rahim, Roslina
author_sort	Hamad Mohamed, Zenab B.
title	Tualang honey effects on high cholesterol diet induced nonalcoholic steatohepatitis in an animal model
title_short	Tualang honey effects on high cholesterol diet induced nonalcoholic steatohepatitis in an animal model
title_full	Tualang honey effects on high cholesterol diet induced nonalcoholic steatohepatitis in an animal model
title_fullStr	Tualang honey effects on high cholesterol diet induced nonalcoholic steatohepatitis in an animal model
title_full_unstemmed	Tualang honey effects on high cholesterol diet induced nonalcoholic steatohepatitis in an animal model
title_sort	tualang honey effects on high cholesterol diet induced nonalcoholic steatohepatitis in an animal model
publisher	World Journal Of Pharmacy And Pharmaceutical Sciences
publishDate	2018
url	http://irep.iium.edu.my/61863/ http://irep.iium.edu.my/61863/ http://irep.iium.edu.my/61863/1/article_wjpps_1517713076.pdf
first_indexed	2023-09-18T21:27:45Z
last_indexed	2023-09-18T21:27:45Z
_version_	1777412306051792896

Tualang honey effects on high cholesterol diet induced nonalcoholic steatohepatitis in an animal model

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