$Fabrication of face cream containing enriched fraction of protocatechuic acid from Clinacanthus nutans (C. Nutans) leaves$

Fabrication of face cream containing enriched fraction of protocatechuic acid from Clinacanthus nutans (C. Nutans) leaves

INTRODUCTION: C. nutans is predominantly native to Malaysia and contains variety of bioactive constituents including protocatechuic acid (PCA). PCA was found to have cosmeceutical value which protects skin from oxidative stress. Emulsion is a dispersion of a liquid in other immiscible liquid with su...

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Main Authors:	Zamery, Muhammad 'Izzuddin, Ab. Hadi, Hazrina
Format:	Article
Language:	English English
Published:	Malaysian Pharmaceutical Society 2017
Subjects:	RS192 Materia Medica-Pharmaceutical Technology
Online Access:	http://irep.iium.edu.my/61752/ http://irep.iium.edu.my/61752/ http://irep.iium.edu.my/61752/19/61752-Fabrication.pdf http://irep.iium.edu.my/61752/4/Poster_FABRICATION%20OF%20FACE%20CREAM%20CONTAINING%20ENRICHED%20FRACTION%20OF.pdf

id	iium-61752
recordtype	eprints
spelling	iium-617522018-02-06T03:22:58Z http://irep.iium.edu.my/61752/ Fabrication of face cream containing enriched fraction of protocatechuic acid from Clinacanthus nutans (C. Nutans) leaves Zamery, Muhammad 'Izzuddin Ab. Hadi, Hazrina RS192 Materia Medica-Pharmaceutical Technology INTRODUCTION: C. nutans is predominantly native to Malaysia and contains variety of bioactive constituents including protocatechuic acid (PCA). PCA was found to have cosmeceutical value which protects skin from oxidative stress. Emulsion is a dispersion of a liquid in other immiscible liquid with surfactant as stabilizer. Most cosmetics developed as oil-in-water emulsion and required to have certain criteria such as homogenous, mild-to-skin and stable. OBJECTIVES: To formulate and characterise a face cream containing PCA enriched fraction. METHODS: Cream formulation involves 82.7% aqueous and 15% oil and 2.3% cooling phases. It was formulated via double boiling, agitation and homogenization techniques. Formulated cream was characterised by evaluating physical (phase separation before and after centrifugation), organoleptic (visual, colour, odour and texture), particle size, zeta potential, rheology, pH and microbial contamination and PCA quantification by high-performance liquid chromatography (HPLC) analyses. RESULTS: A homogenous cream was formulated having light yellow colour, smooth texture and chamomile scent. Centrifugation test showed no phase separation. Particle size of the cream was 4.27±0.05µm with the span value of 0.55±0.02. Zeta potential of the cream was -68.3±0.8mV. The rheological analysis of the cream showed flow behaviour of pseudoplastic non-newtonian. Then, pH of the cream was 5.14±0.02. All microbial limit test showed absent of microbial growth. HPLC analysis showed the PCA peak clearly at 8.122 minutes retention time. CONCLUSION: Face cream containing PCA enriched fraction from C. nutans leaves was formulated. The parameters for cream characterization were within the specification. Malaysian Pharmaceutical Society 2017-11 Article PeerReviewed application/pdf en http://irep.iium.edu.my/61752/19/61752-Fabrication.pdf application/pdf en http://irep.iium.edu.my/61752/4/Poster_FABRICATION%20OF%20FACE%20CREAM%20CONTAINING%20ENRICHED%20FRACTION%20OF.pdf Zamery, Muhammad 'Izzuddin and Ab. Hadi, Hazrina (2017) Fabrication of face cream containing enriched fraction of protocatechuic acid from Clinacanthus nutans (C. Nutans) leaves. Malaysian Journal of Pharmacy, 3 (1 (Supplement)). p. 47. ISSN 1675-3666 http://www.mps.org.my/index.cfm?&menuid=146
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS192 Materia Medica-Pharmaceutical Technology
spellingShingle	RS192 Materia Medica-Pharmaceutical Technology Zamery, Muhammad 'Izzuddin Ab. Hadi, Hazrina Fabrication of face cream containing enriched fraction of protocatechuic acid from Clinacanthus nutans (C. Nutans) leaves
description	INTRODUCTION: C. nutans is predominantly native to Malaysia and contains variety of bioactive constituents including protocatechuic acid (PCA). PCA was found to have cosmeceutical value which protects skin from oxidative stress. Emulsion is a dispersion of a liquid in other immiscible liquid with surfactant as stabilizer. Most cosmetics developed as oil-in-water emulsion and required to have certain criteria such as homogenous, mild-to-skin and stable. OBJECTIVES: To formulate and characterise a face cream containing PCA enriched fraction. METHODS: Cream formulation involves 82.7% aqueous and 15% oil and 2.3% cooling phases. It was formulated via double boiling, agitation and homogenization techniques. Formulated cream was characterised by evaluating physical (phase separation before and after centrifugation), organoleptic (visual, colour, odour and texture), particle size, zeta potential, rheology, pH and microbial contamination and PCA quantification by high-performance liquid chromatography (HPLC) analyses. RESULTS: A homogenous cream was formulated having light yellow colour, smooth texture and chamomile scent. Centrifugation test showed no phase separation. Particle size of the cream was 4.27±0.05µm with the span value of 0.55±0.02. Zeta potential of the cream was -68.3±0.8mV. The rheological analysis of the cream showed flow behaviour of pseudoplastic non-newtonian. Then, pH of the cream was 5.14±0.02. All microbial limit test showed absent of microbial growth. HPLC analysis showed the PCA peak clearly at 8.122 minutes retention time. CONCLUSION: Face cream containing PCA enriched fraction from C. nutans leaves was formulated. The parameters for cream characterization were within the specification.
format	Article
author	Zamery, Muhammad 'Izzuddin Ab. Hadi, Hazrina
author_facet	Zamery, Muhammad 'Izzuddin Ab. Hadi, Hazrina
author_sort	Zamery, Muhammad 'Izzuddin
title	Fabrication of face cream containing enriched fraction of protocatechuic acid from Clinacanthus nutans (C. Nutans) leaves
title_short	Fabrication of face cream containing enriched fraction of protocatechuic acid from Clinacanthus nutans (C. Nutans) leaves
title_full	Fabrication of face cream containing enriched fraction of protocatechuic acid from Clinacanthus nutans (C. Nutans) leaves
title_fullStr	Fabrication of face cream containing enriched fraction of protocatechuic acid from Clinacanthus nutans (C. Nutans) leaves
title_full_unstemmed	Fabrication of face cream containing enriched fraction of protocatechuic acid from Clinacanthus nutans (C. Nutans) leaves
title_sort	fabrication of face cream containing enriched fraction of protocatechuic acid from clinacanthus nutans (c. nutans) leaves
publisher	Malaysian Pharmaceutical Society
publishDate	2017
url	http://irep.iium.edu.my/61752/ http://irep.iium.edu.my/61752/ http://irep.iium.edu.my/61752/19/61752-Fabrication.pdf http://irep.iium.edu.my/61752/4/Poster_FABRICATION%20OF%20FACE%20CREAM%20CONTAINING%20ENRICHED%20FRACTION%20OF.pdf
first_indexed	2023-09-18T21:27:34Z
last_indexed	2023-09-18T21:27:34Z
_version_	1777412293871534080

Fabrication of face cream containing enriched fraction of protocatechuic acid from Clinacanthus nutans (C. Nutans) leaves

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