Antioxidant and cytotoxic activities of Calophyllum rubiginosum

Clusiaceae / Guttiferae an evergreen shrubs or trees, it is considered as a family of 27 genera and 1090 species. Calophyllum rubiginosum one of these species and belongs to this family. In Malaysia they use it as folk remedies, where they believe its’ activity. Problem: Evaluation of antioxidant a...

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Main Authors:	Alkhamaiseh, Suhaib Ibrahim, Bakhtiar, M. Taher, Ahmad, Farediah, Arief Ichwan, Solachuddin Jauhari, Darnis, Deny Susanti
Format:	Article
Language:	English
Published:	Advanced Research Journals 2011
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/6167/ http://irep.iium.edu.my/6167/ http://irep.iium.edu.my/6167/1/Int_J_Phytomedicine.pdf

id	iium-6167
recordtype	eprints
spelling	iium-61672012-07-19T08:16:49Z http://irep.iium.edu.my/6167/ Antioxidant and cytotoxic activities of Calophyllum rubiginosum Alkhamaiseh, Suhaib Ibrahim Bakhtiar, M. Taher Ahmad, Farediah Arief Ichwan, Solachuddin Jauhari Darnis, Deny Susanti Q Science (General) Clusiaceae / Guttiferae an evergreen shrubs or trees, it is considered as a family of 27 genera and 1090 species. Calophyllum rubiginosum one of these species and belongs to this family. In Malaysia they use it as folk remedies, where they believe its’ activity. Problem: Evaluation of antioxidant and cytotoxic activities of three fractions. n-hexane, dichloromethane (DCM) and methanol (MeOH) of Calophyllum rubiginosum species. Approach: The three main fractions were tested to find out the antioxidant capacity using three different methods, DPPH radical scavenging, reducing power and chelating iron ions. The fractions were tested against lung cancer A-549 cell line to assess the anti-proliferation activity. Results: The MeOH fraction showed no effect against lung cancer cell line but achieved a significant result in antioxidant testing. The DCM and n-hexane fractions considered as moderate antioxidant agent, they showed a significant result against lung cancer cell line. Non and semi polar fractions were able to inhibit the proliferation of A-549 cell line at low concentration. The results were statistically significant (P< 0.05). Conclusions: C. rubiginosum fractions have showed significant activity. DCM and n-hexane fractions proved to be effective against A-549 lung cancer cell line, where they were able to disturb the cell proliferation. These results can benefit the local community, and to guide how to use this plant. Advanced Research Journals 2011 Article PeerReviewed application/pdf en http://irep.iium.edu.my/6167/1/Int_J_Phytomedicine.pdf Alkhamaiseh, Suhaib Ibrahim and Bakhtiar, M. Taher and Ahmad, Farediah and Arief Ichwan, Solachuddin Jauhari and Darnis, Deny Susanti (2011) Antioxidant and cytotoxic activities of Calophyllum rubiginosum. International Journal of Phytomedicine, 3 (2). pp. 157-163. ISSN 0975-0185 (P) http://www.arjournals.org/index.php/ijpm/article/view/245/303
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	Q Science (General)
spellingShingle	Q Science (General) Alkhamaiseh, Suhaib Ibrahim Bakhtiar, M. Taher Ahmad, Farediah Arief Ichwan, Solachuddin Jauhari Darnis, Deny Susanti Antioxidant and cytotoxic activities of Calophyllum rubiginosum
description	Clusiaceae / Guttiferae an evergreen shrubs or trees, it is considered as a family of 27 genera and 1090 species. Calophyllum rubiginosum one of these species and belongs to this family. In Malaysia they use it as folk remedies, where they believe its’ activity. Problem: Evaluation of antioxidant and cytotoxic activities of three fractions. n-hexane, dichloromethane (DCM) and methanol (MeOH) of Calophyllum rubiginosum species. Approach: The three main fractions were tested to find out the antioxidant capacity using three different methods, DPPH radical scavenging, reducing power and chelating iron ions. The fractions were tested against lung cancer A-549 cell line to assess the anti-proliferation activity. Results: The MeOH fraction showed no effect against lung cancer cell line but achieved a significant result in antioxidant testing. The DCM and n-hexane fractions considered as moderate antioxidant agent, they showed a significant result against lung cancer cell line. Non and semi polar fractions were able to inhibit the proliferation of A-549 cell line at low concentration. The results were statistically significant (P< 0.05). Conclusions: C. rubiginosum fractions have showed significant activity. DCM and n-hexane fractions proved to be effective against A-549 lung cancer cell line, where they were able to disturb the cell proliferation. These results can benefit the local community, and to guide how to use this plant.
format	Article
author	Alkhamaiseh, Suhaib Ibrahim Bakhtiar, M. Taher Ahmad, Farediah Arief Ichwan, Solachuddin Jauhari Darnis, Deny Susanti
author_facet	Alkhamaiseh, Suhaib Ibrahim Bakhtiar, M. Taher Ahmad, Farediah Arief Ichwan, Solachuddin Jauhari Darnis, Deny Susanti
author_sort	Alkhamaiseh, Suhaib Ibrahim
title	Antioxidant and cytotoxic activities of Calophyllum rubiginosum
title_short	Antioxidant and cytotoxic activities of Calophyllum rubiginosum
title_full	Antioxidant and cytotoxic activities of Calophyllum rubiginosum
title_fullStr	Antioxidant and cytotoxic activities of Calophyllum rubiginosum
title_full_unstemmed	Antioxidant and cytotoxic activities of Calophyllum rubiginosum
title_sort	antioxidant and cytotoxic activities of calophyllum rubiginosum
publisher	Advanced Research Journals
publishDate	2011
url	http://irep.iium.edu.my/6167/ http://irep.iium.edu.my/6167/ http://irep.iium.edu.my/6167/1/Int_J_Phytomedicine.pdf
first_indexed	2023-09-18T20:15:00Z
last_indexed	2023-09-18T20:15:00Z
_version_	1777407728661037056

Antioxidant and cytotoxic activities of Calophyllum rubiginosum

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