Phytochemical analysis and acute oral toxicity study of the ethanolic leaves extract of Plectranthus amboinensis (Lour) Spreng

Phytochemical analysis on the crude ethanolic extract of leaves of Malaysian Plectranthus amboinensis (Lour) Spreng was carried out to delineate the presence of its chemical constituents like Alkaloid, Flavonoid, Saponin, Triterpenoid, Steroid, and Phenolic. Acute oral toxicity at one dose level of...

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Main Authors:	Ramli, Norazsida, Syed Ahmad, Pakeer Oothuman, Bakhtiar, M. Taher, M.El-Hady, Hassan
Format:	Conference or Workshop Item
Language:	English
Published:	Forest Research Institute Malaysia (FRIM) 2013
Subjects:	Q Science (General) QK Botany QL Zoology
Online Access:	http://irep.iium.edu.my/61582/ http://irep.iium.edu.my/61582/1/61582_Phytochemical%20analysis%20and%20acute%20oral.pdf

id	iium-61582
recordtype	eprints
spelling	iium-615822018-06-26T02:42:10Z http://irep.iium.edu.my/61582/ Phytochemical analysis and acute oral toxicity study of the ethanolic leaves extract of Plectranthus amboinensis (Lour) Spreng Ramli, Norazsida Syed Ahmad, Pakeer Oothuman Bakhtiar, M. Taher M.El-Hady, Hassan Q Science (General) QK Botany QL Zoology Phytochemical analysis on the crude ethanolic extract of leaves of Malaysian Plectranthus amboinensis (Lour) Spreng was carried out to delineate the presence of its chemical constituents like Alkaloid, Flavonoid, Saponin, Triterpenoid, Steroid, and Phenolic. Acute oral toxicity at one dose level of 5000 mg/kg as per OECD Guideline for Testing of Chemicals 423 was conducted to evaluate the safeness of this extract to be consumed by humans. 20 mice were divided into one control group and one experimental group. All the mice were observed for signs of toxicity, mortality, weight changes and gross pathological changes. Results on phytochemical analysis showed only flavanoid was present in the extract. The acute oral toxicity test revealed that no mortality or evidence of adverse effects were seen in the treated mice. Studies on histopathological examination of kidneys and liver showed normal architecture suggesting no morphological changes. Thus this ethanolic extract of leave P. amboinensis can be considered as safe as it did not cause either any lethality or adverse changes in mice. Forest Research Institute Malaysia (FRIM) 2013-10-01 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/61582/1/61582_Phytochemical%20analysis%20and%20acute%20oral.pdf Ramli, Norazsida and Syed Ahmad, Pakeer Oothuman and Bakhtiar, M. Taher and M.El-Hady, Hassan (2013) Phytochemical analysis and acute oral toxicity study of the ethanolic leaves extract of Plectranthus amboinensis (Lour) Spreng. In: 13th Medicinal and Aromatic Plants Seminar (MAPS-13), 25th-26th Sept. 2013, Kuala Lumpur, Malaysia.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	Q Science (General) QK Botany QL Zoology
spellingShingle	Q Science (General) QK Botany QL Zoology Ramli, Norazsida Syed Ahmad, Pakeer Oothuman Bakhtiar, M. Taher M.El-Hady, Hassan Phytochemical analysis and acute oral toxicity study of the ethanolic leaves extract of Plectranthus amboinensis (Lour) Spreng
description	Phytochemical analysis on the crude ethanolic extract of leaves of Malaysian Plectranthus amboinensis (Lour) Spreng was carried out to delineate the presence of its chemical constituents like Alkaloid, Flavonoid, Saponin, Triterpenoid, Steroid, and Phenolic. Acute oral toxicity at one dose level of 5000 mg/kg as per OECD Guideline for Testing of Chemicals 423 was conducted to evaluate the safeness of this extract to be consumed by humans. 20 mice were divided into one control group and one experimental group. All the mice were observed for signs of toxicity, mortality, weight changes and gross pathological changes. Results on phytochemical analysis showed only flavanoid was present in the extract. The acute oral toxicity test revealed that no mortality or evidence of adverse effects were seen in the treated mice. Studies on histopathological examination of kidneys and liver showed normal architecture suggesting no morphological changes. Thus this ethanolic extract of leave P. amboinensis can be considered as safe as it did not cause either any lethality or adverse changes in mice.
format	Conference or Workshop Item
author	Ramli, Norazsida Syed Ahmad, Pakeer Oothuman Bakhtiar, M. Taher M.El-Hady, Hassan
author_facet	Ramli, Norazsida Syed Ahmad, Pakeer Oothuman Bakhtiar, M. Taher M.El-Hady, Hassan
author_sort	Ramli, Norazsida
title	Phytochemical analysis and acute oral toxicity study of the ethanolic leaves extract of Plectranthus amboinensis (Lour) Spreng
title_short	Phytochemical analysis and acute oral toxicity study of the ethanolic leaves extract of Plectranthus amboinensis (Lour) Spreng
title_full	Phytochemical analysis and acute oral toxicity study of the ethanolic leaves extract of Plectranthus amboinensis (Lour) Spreng
title_fullStr	Phytochemical analysis and acute oral toxicity study of the ethanolic leaves extract of Plectranthus amboinensis (Lour) Spreng
title_full_unstemmed	Phytochemical analysis and acute oral toxicity study of the ethanolic leaves extract of Plectranthus amboinensis (Lour) Spreng
title_sort	phytochemical analysis and acute oral toxicity study of the ethanolic leaves extract of plectranthus amboinensis (lour) spreng
publisher	Forest Research Institute Malaysia (FRIM)
publishDate	2013
url	http://irep.iium.edu.my/61582/ http://irep.iium.edu.my/61582/1/61582_Phytochemical%20analysis%20and%20acute%20oral.pdf
first_indexed	2023-09-18T21:27:19Z
last_indexed	2023-09-18T21:27:19Z
_version_	1777412278503604224

Phytochemical analysis and acute oral toxicity study of the ethanolic leaves extract of Plectranthus amboinensis (Lour) Spreng

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