The leptin transduction pathway may be targeted against invasive ductal carcinoma of breast

Despite some controversies, it is generally suggested that obesity imparts a higher risk of breast cancer, the most common cancer among women all over the world. Since obese people usually have higher serum levels of leptin, a hormone secreted by white adipose tissue, the hormone is suspected as the...

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Main Authors:	M.Rahman, Shaikh, Abdulrazzaq, Saad Mohammed, Mohammad Amjad, Nasser, Al-Kubaisi, Muna Khaleel Dheyab, Harun, Norra, Nafie, Emad M.
Format:	Article
Language:	English
Published:	American Association For Cancer Research (AACR) 2018
Subjects:	RD93 Emergency Surgery. Wounds and Injuries RG Gynecology and obstetrics
Online Access:	http://irep.iium.edu.my/61479/ http://irep.iium.edu.my/61479/ http://irep.iium.edu.my/61479/ http://irep.iium.edu.my/61479/1/61479_The%20leptin%20transduction.pdf

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recordtype	eprints
spelling	iium-614792018-07-11T00:27:36Z http://irep.iium.edu.my/61479/ The leptin transduction pathway may be targeted against invasive ductal carcinoma of breast M.Rahman, Shaikh Abdulrazzaq, Saad Mohammed Mohammad Amjad, Nasser Al-Kubaisi, Muna Khaleel Dheyab Harun, Norra Nafie, Emad M. RD93 Emergency Surgery. Wounds and Injuries RG Gynecology and obstetrics Despite some controversies, it is generally suggested that obesity imparts a higher risk of breast cancer, the most common cancer among women all over the world. Since obese people usually have higher serum levels of leptin, a hormone secreted by white adipose tissue, the hormone is suspected as the link between adiposity and breast cancer. In this study we tried to explore a possible causal association of obesity and serum leptin with breast cancer by studying a sample of healthy controls and patients from Malaysian population. The control group comprised 40 women with negative mammogram for breast cancer, while the patient group comprised 51 women with invasive ductal carcinoma (IDC) of breast, who were going to be operated. We measured the common obesity parameters, confirmed the diagnosis of IDC of breast in the patients by standard histopathologic examination using hematoxylin and eosin stain, and estimated serum leptin levels using ELISA procedure. We estimated both pre- and postoperative samples of leptin from the patient group. Our results showed a highly significant difference in the serum leptin level between the control group and the patient group with a mean of 20.59 ± 14.4 ng/ml and 38.71 ± 12.2 ng/ml, respectively, having a P value of < 0.001. Our study showed no difference between the pre- and postoperative serum leptin levels in the patient group (P = 0.414). We found no significant difference between body mass index (BMI) of the control and the patient groups (P=0.699), and while in the control group there was strongly positive correlation between serum leptin level and BMI (rs = 0.598, P < 0.01), the patient group showed a positive but much weaker correlation (rs = 0.217, P > 0.05). Our results suggest that compared to BMI, serum leptin has a much stronger association with IDC; since the source of high leptin in serum is not breast cancerous tissue, leptin cannot be a marker for IDC of breast; however, the hormone most likely is causally associated with the tumorigenesis of breast cancer. The results also indicate that obesity, as indicated by BMI, is weakly associated with IDC; however, broader studies with much larger sample sizes are needed to draw any definitive conclusion. We hypothesize that reducing leptin levels, blocking its downstream tissue specific signal transduction, and/or blocking the upstream leptin receptor pathway might help in the prevention and therapy of breast cancer. American Association For Cancer Research (AACR) 2018-01-28 Article PeerReviewed application/pdf en http://irep.iium.edu.my/61479/1/61479_The%20leptin%20transduction.pdf M.Rahman, Shaikh and Abdulrazzaq, Saad Mohammed and Mohammad Amjad, Nasser and Al-Kubaisi, Muna Khaleel Dheyab and Harun, Norra and Nafie, Emad M. (2018) The leptin transduction pathway may be targeted against invasive ductal carcinoma of breast. American Association For Cancer Research (AACR), 17 (1). ISSN 1535-7163 E-ISSN 1538-8514 http://mct.aacrjournals.org/content/17/1_Supplement/A198 10.1158/1535-7163.TARG-17-A198
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RD93 Emergency Surgery. Wounds and Injuries RG Gynecology and obstetrics
spellingShingle	RD93 Emergency Surgery. Wounds and Injuries RG Gynecology and obstetrics M.Rahman, Shaikh Abdulrazzaq, Saad Mohammed Mohammad Amjad, Nasser Al-Kubaisi, Muna Khaleel Dheyab Harun, Norra Nafie, Emad M. The leptin transduction pathway may be targeted against invasive ductal carcinoma of breast
description	Despite some controversies, it is generally suggested that obesity imparts a higher risk of breast cancer, the most common cancer among women all over the world. Since obese people usually have higher serum levels of leptin, a hormone secreted by white adipose tissue, the hormone is suspected as the link between adiposity and breast cancer. In this study we tried to explore a possible causal association of obesity and serum leptin with breast cancer by studying a sample of healthy controls and patients from Malaysian population. The control group comprised 40 women with negative mammogram for breast cancer, while the patient group comprised 51 women with invasive ductal carcinoma (IDC) of breast, who were going to be operated. We measured the common obesity parameters, confirmed the diagnosis of IDC of breast in the patients by standard histopathologic examination using hematoxylin and eosin stain, and estimated serum leptin levels using ELISA procedure. We estimated both pre- and postoperative samples of leptin from the patient group. Our results showed a highly significant difference in the serum leptin level between the control group and the patient group with a mean of 20.59 ± 14.4 ng/ml and 38.71 ± 12.2 ng/ml, respectively, having a P value of < 0.001. Our study showed no difference between the pre- and postoperative serum leptin levels in the patient group (P = 0.414). We found no significant difference between body mass index (BMI) of the control and the patient groups (P=0.699), and while in the control group there was strongly positive correlation between serum leptin level and BMI (rs = 0.598, P < 0.01), the patient group showed a positive but much weaker correlation (rs = 0.217, P > 0.05). Our results suggest that compared to BMI, serum leptin has a much stronger association with IDC; since the source of high leptin in serum is not breast cancerous tissue, leptin cannot be a marker for IDC of breast; however, the hormone most likely is causally associated with the tumorigenesis of breast cancer. The results also indicate that obesity, as indicated by BMI, is weakly associated with IDC; however, broader studies with much larger sample sizes are needed to draw any definitive conclusion. We hypothesize that reducing leptin levels, blocking its downstream tissue specific signal transduction, and/or blocking the upstream leptin receptor pathway might help in the prevention and therapy of breast cancer.
format	Article
author	M.Rahman, Shaikh Abdulrazzaq, Saad Mohammed Mohammad Amjad, Nasser Al-Kubaisi, Muna Khaleel Dheyab Harun, Norra Nafie, Emad M.
author_facet	M.Rahman, Shaikh Abdulrazzaq, Saad Mohammed Mohammad Amjad, Nasser Al-Kubaisi, Muna Khaleel Dheyab Harun, Norra Nafie, Emad M.
author_sort	M.Rahman, Shaikh
title	The leptin transduction pathway may be targeted against invasive ductal carcinoma of breast
title_short	The leptin transduction pathway may be targeted against invasive ductal carcinoma of breast
title_full	The leptin transduction pathway may be targeted against invasive ductal carcinoma of breast
title_fullStr	The leptin transduction pathway may be targeted against invasive ductal carcinoma of breast
title_full_unstemmed	The leptin transduction pathway may be targeted against invasive ductal carcinoma of breast
title_sort	leptin transduction pathway may be targeted against invasive ductal carcinoma of breast
publisher	American Association For Cancer Research (AACR)
publishDate	2018
url	http://irep.iium.edu.my/61479/ http://irep.iium.edu.my/61479/ http://irep.iium.edu.my/61479/ http://irep.iium.edu.my/61479/1/61479_The%20leptin%20transduction.pdf
first_indexed	2023-09-18T21:27:12Z
last_indexed	2023-09-18T21:27:12Z
_version_	1777412271306178560

The leptin transduction pathway may be targeted against invasive ductal carcinoma of breast

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