Renoprotective role of tualang honey against high cholesterol diet induced acute kidney diseases in an animal model

The aim of this study is to determine the renoprotective effects of tualang honey against high cholesterol diet (HCD) induced acute and subacute kidney injuries in an animal model. Methodology: Ten female Sprague-Dawley rats were divided into two groups: the HCD group, fed with 12% cholesterol diet,...

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Main Authors:	Hamad Mohamed, Zenab B., Hamad Alfarisi, Hamad Abdulsalam, Abdullah, Nor Zamzila, Harun, Norra, Muhammad, Naznin, Abdul Rahim, Roslina
Format:	Article
Language:	English English
Published:	2017
Subjects:	QM Human anatomy QP Physiology RB Pathology RC Internal medicine RZ Other systems of medicine
Online Access:	http://irep.iium.edu.my/61278/ http://irep.iium.edu.my/61278/ http://irep.iium.edu.my/61278/ http://irep.iium.edu.my/61278/1/2506_pdf.pdf http://irep.iium.edu.my/61278/7/61278_Renoprotective%20role%20of%20tualang%20honey%20against%20high%20cholesterol_SCOPUS.pdf

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spelling	iium-612782018-05-17T02:52:41Z http://irep.iium.edu.my/61278/ Renoprotective role of tualang honey against high cholesterol diet induced acute kidney diseases in an animal model Hamad Mohamed, Zenab B. Hamad Alfarisi, Hamad Abdulsalam Abdullah, Nor Zamzila Harun, Norra Muhammad, Naznin Abdul Rahim, Roslina QM Human anatomy QP Physiology RB Pathology RC Internal medicine RZ Other systems of medicine The aim of this study is to determine the renoprotective effects of tualang honey against high cholesterol diet (HCD) induced acute and subacute kidney injuries in an animal model. Methodology: Ten female Sprague-Dawley rats were divided into two groups: the HCD group, fed with 12% cholesterol diet, and the HCD with tualang honey (HCD+TH) group, fed with HCD and daily dose of 1.4g/kg/day of tualang honey. Biochemical analysis of lipid and renal profiles were performed at 48 hours, 7 days, and 6 weeks. The animals were sacrificed after 6 weeks and the kidneys were harvested for histological examination. Results: The serum cholesterol and trigelyceride levels were significantly lower in the HCD+TH group as compared to the HCD group at 7 days with p values of 0.025 and 0.031 respectively. The HCD+TH group showed significantly lower serum creatinine level than the HCD group at 48 hours (p=0.018). The histological sections of the renal tissue of the HCD and HCD+TH groups both revealed segmental mesangial hypercellularity and mesangial matrix expansion of the glomeruli. Conclusion: Our study revealed that tualang honey exhibited some degree of renoprotective effect biochemically but not histologically in the rat models fed with high cholesterol diet. 2017-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/61278/1/2506_pdf.pdf application/pdf en http://irep.iium.edu.my/61278/7/61278_Renoprotective%20role%20of%20tualang%20honey%20against%20high%20cholesterol_SCOPUS.pdf Hamad Mohamed, Zenab B. and Hamad Alfarisi, Hamad Abdulsalam and Abdullah, Nor Zamzila and Harun, Norra and Muhammad, Naznin and Abdul Rahim, Roslina (2017) Renoprotective role of tualang honey against high cholesterol diet induced acute kidney diseases in an animal model. Journal of Applied Pharmaceutical Science, 7 (12). pp. 97-101. ISSN 2231-3354 http://www.japsonline.com DOI: 10.7324/JAPS.2017.71213
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QM Human anatomy QP Physiology RB Pathology RC Internal medicine RZ Other systems of medicine
spellingShingle	QM Human anatomy QP Physiology RB Pathology RC Internal medicine RZ Other systems of medicine Hamad Mohamed, Zenab B. Hamad Alfarisi, Hamad Abdulsalam Abdullah, Nor Zamzila Harun, Norra Muhammad, Naznin Abdul Rahim, Roslina Renoprotective role of tualang honey against high cholesterol diet induced acute kidney diseases in an animal model
description	The aim of this study is to determine the renoprotective effects of tualang honey against high cholesterol diet (HCD) induced acute and subacute kidney injuries in an animal model. Methodology: Ten female Sprague-Dawley rats were divided into two groups: the HCD group, fed with 12% cholesterol diet, and the HCD with tualang honey (HCD+TH) group, fed with HCD and daily dose of 1.4g/kg/day of tualang honey. Biochemical analysis of lipid and renal profiles were performed at 48 hours, 7 days, and 6 weeks. The animals were sacrificed after 6 weeks and the kidneys were harvested for histological examination. Results: The serum cholesterol and trigelyceride levels were significantly lower in the HCD+TH group as compared to the HCD group at 7 days with p values of 0.025 and 0.031 respectively. The HCD+TH group showed significantly lower serum creatinine level than the HCD group at 48 hours (p=0.018). The histological sections of the renal tissue of the HCD and HCD+TH groups both revealed segmental mesangial hypercellularity and mesangial matrix expansion of the glomeruli. Conclusion: Our study revealed that tualang honey exhibited some degree of renoprotective effect biochemically but not histologically in the rat models fed with high cholesterol diet.
format	Article
author	Hamad Mohamed, Zenab B. Hamad Alfarisi, Hamad Abdulsalam Abdullah, Nor Zamzila Harun, Norra Muhammad, Naznin Abdul Rahim, Roslina
author_facet	Hamad Mohamed, Zenab B. Hamad Alfarisi, Hamad Abdulsalam Abdullah, Nor Zamzila Harun, Norra Muhammad, Naznin Abdul Rahim, Roslina
author_sort	Hamad Mohamed, Zenab B.
title	Renoprotective role of tualang honey against high cholesterol diet induced acute kidney diseases in an animal model
title_short	Renoprotective role of tualang honey against high cholesterol diet induced acute kidney diseases in an animal model
title_full	Renoprotective role of tualang honey against high cholesterol diet induced acute kidney diseases in an animal model
title_fullStr	Renoprotective role of tualang honey against high cholesterol diet induced acute kidney diseases in an animal model
title_full_unstemmed	Renoprotective role of tualang honey against high cholesterol diet induced acute kidney diseases in an animal model
title_sort	renoprotective role of tualang honey against high cholesterol diet induced acute kidney diseases in an animal model
publishDate	2017
url	http://irep.iium.edu.my/61278/ http://irep.iium.edu.my/61278/ http://irep.iium.edu.my/61278/ http://irep.iium.edu.my/61278/1/2506_pdf.pdf http://irep.iium.edu.my/61278/7/61278_Renoprotective%20role%20of%20tualang%20honey%20against%20high%20cholesterol_SCOPUS.pdf
first_indexed	2023-09-18T21:26:54Z
last_indexed	2023-09-18T21:26:54Z
_version_	1777412251844608000

Renoprotective role of tualang honey against high cholesterol diet induced acute kidney diseases in an animal model

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