Evaluation of proton pump inhibitors prescribing among non-critically ill hospitalized patients in a Malaysian tertiary hospital

Background: There are raised concerns regarding the rational guidelines-based prescribing of proton pump inhibitors (PPIs) therapy in the hospital setting. Objective: To describe the current prescribing practice of PPIs among hospitalized patients in non-intensive care settings. Also, the study aim...

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Main Authors:	Elnaem, Mohamed Hassan, Nik Mohamed, Mohamad Haniki, Nazar, Amirul Hazim, Ibrahim, Rabiatul Nur Khaliesa
Format:	Article
Language:	English English
Published:	Open Science Publishers LLP 2017
Subjects:	RC803 Specialties of Internal Medicine-Diseases of The Digestive System. Gastroenterology RM Therapeutics. Pharmacology RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/61261/ http://irep.iium.edu.my/61261/ http://irep.iium.edu.my/61261/ http://irep.iium.edu.my/61261/1/PPIs%20Evaluation%20J%20App%20Pharm%20Sci%20Dec%202017.pdf http://irep.iium.edu.my/61261/7/61261_Evaluation%20of%20proton%20pump%20inhibitors%20prescribing%20among%20non-critically_SCOPUS.pdf

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spelling	iium-612612018-04-25T02:17:05Z http://irep.iium.edu.my/61261/ Evaluation of proton pump inhibitors prescribing among non-critically ill hospitalized patients in a Malaysian tertiary hospital Elnaem, Mohamed Hassan Nik Mohamed, Mohamad Haniki Nazar, Amirul Hazim Ibrahim, Rabiatul Nur Khaliesa RC803 Specialties of Internal Medicine-Diseases of The Digestive System. Gastroenterology RM Therapeutics. Pharmacology RS Pharmacy and materia medica Background: There are raised concerns regarding the rational guidelines-based prescribing of proton pump inhibitors (PPIs) therapy in the hospital setting. Objective: To describe the current prescribing practice of PPIs among hospitalized patients in non-intensive care settings. Also, the study aimed to evaluate the appropriateness of the prescribed PPIs. Methods: A cross-sectional study was conducted in the medical ward of a tertiary hospital in the state of Pahang, Malaysia. A total of 153 medical records of non-critically-ill adult patients receiving PPI therapy were investigated. The assessment of PPI prescribing was performed referring to clinical guidelines and the list of PPI-approved indications. Results: The most frequently prescribed PPI regimen has been pantoprazole 40 mg OD. Approximately 34% of the prescribed regimens were considered to be appropriate as it was consistent with the clinical guidelines. However, about 31% of the prescribed PPIs did not have a clear indication. Moreover, the inappropriate use of PPIs was revealed in nearly 19% of the total PPIs prescriptions. Finally, 16% of the prescribed PPIs were in need of dosage adjustment due to the presence of drug-drug interactions with the concurrently used medications. Conclusion: Inappropriately prescribed PPIs are prevalent among non-critically ill-hospitalized adult patients in a Malaysian tertiary hospital. Initiatives for enforcing rational prescribing should focus on the proper documentation of evidence-based indications of PPIs in the medical records. There is a desperate need in the local setting for well-defined PPIs prescribing criteria. Future research should design and examine the impact of prescribing improvement interventions on the PPIs rational prescribing. Open Science Publishers LLP 2017-12 Article PeerReviewed application/pdf en cc_by_nc_sa http://irep.iium.edu.my/61261/1/PPIs%20Evaluation%20J%20App%20Pharm%20Sci%20Dec%202017.pdf application/pdf en http://irep.iium.edu.my/61261/7/61261_Evaluation%20of%20proton%20pump%20inhibitors%20prescribing%20among%20non-critically_SCOPUS.pdf Elnaem, Mohamed Hassan and Nik Mohamed, Mohamad Haniki and Nazar, Amirul Hazim and Ibrahim, Rabiatul Nur Khaliesa (2017) Evaluation of proton pump inhibitors prescribing among non-critically ill hospitalized patients in a Malaysian tertiary hospital. Journal of Applied Pharmaceutical Science, 7 (12). 077-083. ISSN 2231-3354 http://www.japsonline.com/admin/php/uploads/2503_pdf.pdf 10.7324/JAPS.2017.71210
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RC803 Specialties of Internal Medicine-Diseases of The Digestive System. Gastroenterology RM Therapeutics. Pharmacology RS Pharmacy and materia medica
spellingShingle	RC803 Specialties of Internal Medicine-Diseases of The Digestive System. Gastroenterology RM Therapeutics. Pharmacology RS Pharmacy and materia medica Elnaem, Mohamed Hassan Nik Mohamed, Mohamad Haniki Nazar, Amirul Hazim Ibrahim, Rabiatul Nur Khaliesa Evaluation of proton pump inhibitors prescribing among non-critically ill hospitalized patients in a Malaysian tertiary hospital
description	Background: There are raised concerns regarding the rational guidelines-based prescribing of proton pump inhibitors (PPIs) therapy in the hospital setting. Objective: To describe the current prescribing practice of PPIs among hospitalized patients in non-intensive care settings. Also, the study aimed to evaluate the appropriateness of the prescribed PPIs. Methods: A cross-sectional study was conducted in the medical ward of a tertiary hospital in the state of Pahang, Malaysia. A total of 153 medical records of non-critically-ill adult patients receiving PPI therapy were investigated. The assessment of PPI prescribing was performed referring to clinical guidelines and the list of PPI-approved indications. Results: The most frequently prescribed PPI regimen has been pantoprazole 40 mg OD. Approximately 34% of the prescribed regimens were considered to be appropriate as it was consistent with the clinical guidelines. However, about 31% of the prescribed PPIs did not have a clear indication. Moreover, the inappropriate use of PPIs was revealed in nearly 19% of the total PPIs prescriptions. Finally, 16% of the prescribed PPIs were in need of dosage adjustment due to the presence of drug-drug interactions with the concurrently used medications. Conclusion: Inappropriately prescribed PPIs are prevalent among non-critically ill-hospitalized adult patients in a Malaysian tertiary hospital. Initiatives for enforcing rational prescribing should focus on the proper documentation of evidence-based indications of PPIs in the medical records. There is a desperate need in the local setting for well-defined PPIs prescribing criteria. Future research should design and examine the impact of prescribing improvement interventions on the PPIs rational prescribing.
format	Article
author	Elnaem, Mohamed Hassan Nik Mohamed, Mohamad Haniki Nazar, Amirul Hazim Ibrahim, Rabiatul Nur Khaliesa
author_facet	Elnaem, Mohamed Hassan Nik Mohamed, Mohamad Haniki Nazar, Amirul Hazim Ibrahim, Rabiatul Nur Khaliesa
author_sort	Elnaem, Mohamed Hassan
title	Evaluation of proton pump inhibitors prescribing among non-critically ill hospitalized patients in a Malaysian tertiary hospital
title_short	Evaluation of proton pump inhibitors prescribing among non-critically ill hospitalized patients in a Malaysian tertiary hospital
title_full	Evaluation of proton pump inhibitors prescribing among non-critically ill hospitalized patients in a Malaysian tertiary hospital
title_fullStr	Evaluation of proton pump inhibitors prescribing among non-critically ill hospitalized patients in a Malaysian tertiary hospital
title_full_unstemmed	Evaluation of proton pump inhibitors prescribing among non-critically ill hospitalized patients in a Malaysian tertiary hospital
title_sort	evaluation of proton pump inhibitors prescribing among non-critically ill hospitalized patients in a malaysian tertiary hospital
publisher	Open Science Publishers LLP
publishDate	2017
url	http://irep.iium.edu.my/61261/ http://irep.iium.edu.my/61261/ http://irep.iium.edu.my/61261/ http://irep.iium.edu.my/61261/1/PPIs%20Evaluation%20J%20App%20Pharm%20Sci%20Dec%202017.pdf http://irep.iium.edu.my/61261/7/61261_Evaluation%20of%20proton%20pump%20inhibitors%20prescribing%20among%20non-critically_SCOPUS.pdf
first_indexed	2023-09-18T21:26:53Z
last_indexed	2023-09-18T21:26:53Z
_version_	1777412250673348608

Evaluation of proton pump inhibitors prescribing among non-critically ill hospitalized patients in a Malaysian tertiary hospital

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