Antioxidant activities of flavonoids isolated from the leaves of Tetracera indica Merr.

Different parts of Tetracera indica Merr. have been claimed by the folk medicine practitioners to have effectiveness in the treatment of diabetes mellitus and anti-inflammatory related diseases. In Malaysian traditional medicine system, the leaves are considered to lessen high blood pressure, diabet...

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Main Authors:	Sarian, Murni Nazira, Ahmed, Qamar Uddin, Murugesu, S., Mat So'ad, Siti Zaiton
Format:	Conference or Workshop Item
Language:	English
Published:	2016
Subjects:	Q Science (General) QD Chemistry
Online Access:	http://irep.iium.edu.my/61095/ http://irep.iium.edu.my/61095/ http://irep.iium.edu.my/61095/18/61095_Antioxidant%20activities%20of%20flavonoids%20isolated%20from%20the%20leaves_complete.pdf

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recordtype	eprints
spelling	iium-610952018-01-25T03:03:27Z http://irep.iium.edu.my/61095/ Antioxidant activities of flavonoids isolated from the leaves of Tetracera indica Merr. Sarian, Murni Nazira Ahmed, Qamar Uddin Murugesu, S. Mat So'ad, Siti Zaiton Q Science (General) QD Chemistry Different parts of Tetracera indica Merr. have been claimed by the folk medicine practitioners to have effectiveness in the treatment of diabetes mellitus and anti-inflammatory related diseases. In Malaysian traditional medicine system, the leaves are considered to lessen high blood pressure, diabetes and high fevers. Powdered leaves of T. indica were macerated with methanol for 72 h and then concentrated methanol extract was subjected to column chromatography (silica gel and sephadex LH 20) to afford three flavonoids (MN1, MN2, and MN5). MN 3 and MN4 were purchased for SAR study. Their structures were elucidated through the interpretation of spectroscopic data (NMR, IR, UV and MS). All compounds were further evaluated for antioxidant activities using rapid test by dot blot, DPPH and xanthine oxidase inhibitory assays. Compounds showed an antioxidant activity through dot blot, DPPH (1,1-diphenyl-2-picryl hydrazyl radical) and low inhibitory effect of xanthine oxidase. Among all five compounds, the MN5 showed the most potent SC50 (46.61) activity in rapid test by dot blot, DPPH, meanwhile MN1, MN4 and MN5 showed low inhibition of xanthine oxidase inhibitory assay. The results might be encouraging in future molecular studies, which could ultimately lead to better understanding the biological mechanism of action due to these compounds. Keywords: Tetracera indica Merr., phytoconstituents, antioxidant activities; DPPH, dot blot, xanthine oxidase inhibitory assay 2016-08 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/61095/18/61095_Antioxidant%20activities%20of%20flavonoids%20isolated%20from%20the%20leaves_complete.pdf Sarian, Murni Nazira and Ahmed, Qamar Uddin and Murugesu, S. and Mat So'ad, Siti Zaiton (2016) Antioxidant activities of flavonoids isolated from the leaves of Tetracera indica Merr. In: 2nd International Conference on Industrial Pharmacy (ICIP 2016):Generics and Biosimilars, 15th-16th Aug. 2016, Kuantan, Pahang. (Unpublished) http://www.iium.edu.my/icip2016/downloads/programmebook.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	Q Science (General) QD Chemistry
spellingShingle	Q Science (General) QD Chemistry Sarian, Murni Nazira Ahmed, Qamar Uddin Murugesu, S. Mat So'ad, Siti Zaiton Antioxidant activities of flavonoids isolated from the leaves of Tetracera indica Merr.
description	Different parts of Tetracera indica Merr. have been claimed by the folk medicine practitioners to have effectiveness in the treatment of diabetes mellitus and anti-inflammatory related diseases. In Malaysian traditional medicine system, the leaves are considered to lessen high blood pressure, diabetes and high fevers. Powdered leaves of T. indica were macerated with methanol for 72 h and then concentrated methanol extract was subjected to column chromatography (silica gel and sephadex LH 20) to afford three flavonoids (MN1, MN2, and MN5). MN 3 and MN4 were purchased for SAR study. Their structures were elucidated through the interpretation of spectroscopic data (NMR, IR, UV and MS). All compounds were further evaluated for antioxidant activities using rapid test by dot blot, DPPH and xanthine oxidase inhibitory assays. Compounds showed an antioxidant activity through dot blot, DPPH (1,1-diphenyl-2-picryl hydrazyl radical) and low inhibitory effect of xanthine oxidase. Among all five compounds, the MN5 showed the most potent SC50 (46.61) activity in rapid test by dot blot, DPPH, meanwhile MN1, MN4 and MN5 showed low inhibition of xanthine oxidase inhibitory assay. The results might be encouraging in future molecular studies, which could ultimately lead to better understanding the biological mechanism of action due to these compounds. Keywords: Tetracera indica Merr., phytoconstituents, antioxidant activities; DPPH, dot blot, xanthine oxidase inhibitory assay
format	Conference or Workshop Item
author	Sarian, Murni Nazira Ahmed, Qamar Uddin Murugesu, S. Mat So'ad, Siti Zaiton
author_facet	Sarian, Murni Nazira Ahmed, Qamar Uddin Murugesu, S. Mat So'ad, Siti Zaiton
author_sort	Sarian, Murni Nazira
title	Antioxidant activities of flavonoids isolated from the leaves of Tetracera indica Merr.
title_short	Antioxidant activities of flavonoids isolated from the leaves of Tetracera indica Merr.
title_full	Antioxidant activities of flavonoids isolated from the leaves of Tetracera indica Merr.
title_fullStr	Antioxidant activities of flavonoids isolated from the leaves of Tetracera indica Merr.
title_full_unstemmed	Antioxidant activities of flavonoids isolated from the leaves of Tetracera indica Merr.
title_sort	antioxidant activities of flavonoids isolated from the leaves of tetracera indica merr.
publishDate	2016
url	http://irep.iium.edu.my/61095/ http://irep.iium.edu.my/61095/ http://irep.iium.edu.my/61095/18/61095_Antioxidant%20activities%20of%20flavonoids%20isolated%20from%20the%20leaves_complete.pdf
first_indexed	2023-09-18T21:26:38Z
last_indexed	2023-09-18T21:26:38Z
_version_	1777412235661934592

Antioxidant activities of flavonoids isolated from the leaves of Tetracera indica Merr.

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