The effect of flaxseed ethanolic extract on the structure of the kidney and the endocrine pancreas in streptozotocin induced diabetic rats

Background: The present investigation has been designed to study the possible protective effect of flaxseed extract on the structures of the endocrine pancreas and kidneys of streptozotocin (STZ) induced diabetic rats for 30 days. Methods: Forty male Sprague-Dawley rats were randomized into five gro...

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Main Authors:	Al-Ani, Ghassan A., Al-Ani, Imad Matloub Dally, Azzubaidi, Marwan Saad, Mustafa Al-Ahmad, Basma Ezzat
Format:	Article
Language:	English English
Published:	Universitas Indonesia, Depok, Indonesia 2017
Subjects:	QM Human anatomy QP Physiology RB Pathology RM Therapeutics. Pharmacology
Online Access:	http://irep.iium.edu.my/61092/ http://irep.iium.edu.my/61092/ http://irep.iium.edu.my/61092/ http://irep.iium.edu.my/61092/2/61092-The%20Effect%20of%20Flaxseed%20Ethanolic%20Extract.pdf http://irep.iium.edu.my/61092/8/61902_The%20effect%20of%20flaxseed%20ethanolic%20extract_WOS.pdf

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spelling	iium-610922018-06-28T01:52:56Z http://irep.iium.edu.my/61092/ The effect of flaxseed ethanolic extract on the structure of the kidney and the endocrine pancreas in streptozotocin induced diabetic rats Al-Ani, Ghassan A. Al-Ani, Imad Matloub Dally Azzubaidi, Marwan Saad Mustafa Al-Ahmad, Basma Ezzat QM Human anatomy QP Physiology RB Pathology RM Therapeutics. Pharmacology Background: The present investigation has been designed to study the possible protective effect of flaxseed extract on the structures of the endocrine pancreas and kidneys of streptozotocin (STZ) induced diabetic rats for 30 days. Methods: Forty male Sprague-Dawley rats were randomized into five groups (n=8). Normal control group (NC); received distilled water orally, normal flaxseed group (NF); treated orally with (400 mg/kg) extract of flaxseed, diabetic control group (DC); treated with single intraperitoneal dose of STZ (60 mg/kg), diabetic flaxseed group (DF); diabetic rats treated with extract of flaxseed (400 mg/kg), diabetic glibenclamide group (DG); diabetic rats treated with (0.6 mg/kg) glibenclamide. Results: Histological observation of sections in pancreas in DC group revealed shrunken islets of Langerhans with degenerated and degranulated β-cells, vacuolations and congested capillaries while sections of kidneys showed shrinkage of some glomeruli and degeneration of others with wide urinary space and hydropic degeneration in some tubular epithelial cells, dilated tubules and cell debris scattered in tubular lumina. These pathological changes were ameliorated in the flaxseed extract and glibenclamide treated rats. Conclusions: It is concluded that flaxseed extract may represent a good alternative treatment for management of diabetes and its related complications such as diabetic nephropathy. Universitas Indonesia, Depok, Indonesia 2017-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/61092/2/61092-The%20Effect%20of%20Flaxseed%20Ethanolic%20Extract.pdf application/pdf en http://irep.iium.edu.my/61092/8/61902_The%20effect%20of%20flaxseed%20ethanolic%20extract_WOS.pdf Al-Ani, Ghassan A. and Al-Ani, Imad Matloub Dally and Azzubaidi, Marwan Saad and Mustafa Al-Ahmad, Basma Ezzat (2017) The effect of flaxseed ethanolic extract on the structure of the kidney and the endocrine pancreas in streptozotocin induced diabetic rats. Makara Journal of Health Research (MJHR), 21 (3). pp. 87-92. ISSN 2356-3664 E-ISSN 2356-3656 http://journal.ui.ac.id/index.php/health/article/view/7225/4011 10.7454/msk.v21i3.7225
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QM Human anatomy QP Physiology RB Pathology RM Therapeutics. Pharmacology
spellingShingle	QM Human anatomy QP Physiology RB Pathology RM Therapeutics. Pharmacology Al-Ani, Ghassan A. Al-Ani, Imad Matloub Dally Azzubaidi, Marwan Saad Mustafa Al-Ahmad, Basma Ezzat The effect of flaxseed ethanolic extract on the structure of the kidney and the endocrine pancreas in streptozotocin induced diabetic rats
description	Background: The present investigation has been designed to study the possible protective effect of flaxseed extract on the structures of the endocrine pancreas and kidneys of streptozotocin (STZ) induced diabetic rats for 30 days. Methods: Forty male Sprague-Dawley rats were randomized into five groups (n=8). Normal control group (NC); received distilled water orally, normal flaxseed group (NF); treated orally with (400 mg/kg) extract of flaxseed, diabetic control group (DC); treated with single intraperitoneal dose of STZ (60 mg/kg), diabetic flaxseed group (DF); diabetic rats treated with extract of flaxseed (400 mg/kg), diabetic glibenclamide group (DG); diabetic rats treated with (0.6 mg/kg) glibenclamide. Results: Histological observation of sections in pancreas in DC group revealed shrunken islets of Langerhans with degenerated and degranulated β-cells, vacuolations and congested capillaries while sections of kidneys showed shrinkage of some glomeruli and degeneration of others with wide urinary space and hydropic degeneration in some tubular epithelial cells, dilated tubules and cell debris scattered in tubular lumina. These pathological changes were ameliorated in the flaxseed extract and glibenclamide treated rats. Conclusions: It is concluded that flaxseed extract may represent a good alternative treatment for management of diabetes and its related complications such as diabetic nephropathy.
format	Article
author	Al-Ani, Ghassan A. Al-Ani, Imad Matloub Dally Azzubaidi, Marwan Saad Mustafa Al-Ahmad, Basma Ezzat
author_facet	Al-Ani, Ghassan A. Al-Ani, Imad Matloub Dally Azzubaidi, Marwan Saad Mustafa Al-Ahmad, Basma Ezzat
author_sort	Al-Ani, Ghassan A.
title	The effect of flaxseed ethanolic extract on the structure of the kidney and the endocrine pancreas in streptozotocin induced diabetic rats
title_short	The effect of flaxseed ethanolic extract on the structure of the kidney and the endocrine pancreas in streptozotocin induced diabetic rats
title_full	The effect of flaxseed ethanolic extract on the structure of the kidney and the endocrine pancreas in streptozotocin induced diabetic rats
title_fullStr	The effect of flaxseed ethanolic extract on the structure of the kidney and the endocrine pancreas in streptozotocin induced diabetic rats
title_full_unstemmed	The effect of flaxseed ethanolic extract on the structure of the kidney and the endocrine pancreas in streptozotocin induced diabetic rats
title_sort	effect of flaxseed ethanolic extract on the structure of the kidney and the endocrine pancreas in streptozotocin induced diabetic rats
publisher	Universitas Indonesia, Depok, Indonesia
publishDate	2017
url	http://irep.iium.edu.my/61092/ http://irep.iium.edu.my/61092/ http://irep.iium.edu.my/61092/ http://irep.iium.edu.my/61092/2/61092-The%20Effect%20of%20Flaxseed%20Ethanolic%20Extract.pdf http://irep.iium.edu.my/61092/8/61902_The%20effect%20of%20flaxseed%20ethanolic%20extract_WOS.pdf
first_indexed	2023-09-18T21:26:38Z
last_indexed	2023-09-18T21:26:38Z
_version_	1777412235224678400

The effect of flaxseed ethanolic extract on the structure of the kidney and the endocrine pancreas in streptozotocin induced diabetic rats

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