Understanding evolutionary processes in bird species using genome-wide sequence analysis

Meiotic recombination is the driving force behind genetic diversity. It happens non-randomly across the genome, with high concentrations in regions called recombination hot spots. Across mammalian species, PRDM9 has shown to be an important player in localizing almost all meiotic recombination hot s...

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Main Authors:	Eltayeb, Muhammad Alfatih, Tumian, Afidalina
Format:	Conference or Workshop Item
Language:	English
Published:	2017
Subjects:	QH301 Biology QH426 Genetics
Online Access:	http://irep.iium.edu.my/60944/ http://irep.iium.edu.my/60944/ http://irep.iium.edu.my/60944/7/arcsb2017.pdf

id	iium-60944
recordtype	eprints
spelling	iium-609442018-01-23T07:15:36Z http://irep.iium.edu.my/60944/ Understanding evolutionary processes in bird species using genome-wide sequence analysis Eltayeb, Muhammad Alfatih Tumian, Afidalina QH301 Biology QH426 Genetics Meiotic recombination is the driving force behind genetic diversity. It happens non-randomly across the genome, with high concentrations in regions called recombination hot spots. Across mammalian species, PRDM9 has shown to be an important player in localizing almost all meiotic recombination hot spots. However in some species such as birds and dogs, it is discovered that the localization of hot spots is unlikely to be regulated by PRDM9 due to disruption to its coding sequence. The rapid evolution of PRDM9 maybe a response to escape the self-disruptive drive called biased gene conversion (BGC). In this paper, we attempt to uncover if we can see any signatures of BGC in bird species by using alignment data consisting of the chicken, domestic turkey, zebra finch and the green anole. By studying relative motif losses and gains across the genomes, we aim to understand the biases and target sites/motifs and consequently to infer recombination lifetimes. 2017-11-20 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/60944/7/arcsb2017.pdf Eltayeb, Muhammad Alfatih and Tumian, Afidalina (2017) Understanding evolutionary processes in bird species using genome-wide sequence analysis. In: The 4th Asian Regional Conference on Systems Biology 2017 (ARCSB2017), 20th-22nd November 2017, Marriott Hotel, Putrajaya. (Unpublished) http://arcsb2017.weebly.com/about.html
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QH301 Biology QH426 Genetics
spellingShingle	QH301 Biology QH426 Genetics Eltayeb, Muhammad Alfatih Tumian, Afidalina Understanding evolutionary processes in bird species using genome-wide sequence analysis
description	Meiotic recombination is the driving force behind genetic diversity. It happens non-randomly across the genome, with high concentrations in regions called recombination hot spots. Across mammalian species, PRDM9 has shown to be an important player in localizing almost all meiotic recombination hot spots. However in some species such as birds and dogs, it is discovered that the localization of hot spots is unlikely to be regulated by PRDM9 due to disruption to its coding sequence. The rapid evolution of PRDM9 maybe a response to escape the self-disruptive drive called biased gene conversion (BGC). In this paper, we attempt to uncover if we can see any signatures of BGC in bird species by using alignment data consisting of the chicken, domestic turkey, zebra finch and the green anole. By studying relative motif losses and gains across the genomes, we aim to understand the biases and target sites/motifs and consequently to infer recombination lifetimes.
format	Conference or Workshop Item
author	Eltayeb, Muhammad Alfatih Tumian, Afidalina
author_facet	Eltayeb, Muhammad Alfatih Tumian, Afidalina
author_sort	Eltayeb, Muhammad Alfatih
title	Understanding evolutionary processes in bird species using genome-wide sequence analysis
title_short	Understanding evolutionary processes in bird species using genome-wide sequence analysis
title_full	Understanding evolutionary processes in bird species using genome-wide sequence analysis
title_fullStr	Understanding evolutionary processes in bird species using genome-wide sequence analysis
title_full_unstemmed	Understanding evolutionary processes in bird species using genome-wide sequence analysis
title_sort	understanding evolutionary processes in bird species using genome-wide sequence analysis
publishDate	2017
url	http://irep.iium.edu.my/60944/ http://irep.iium.edu.my/60944/ http://irep.iium.edu.my/60944/7/arcsb2017.pdf
first_indexed	2023-09-18T21:26:25Z
last_indexed	2023-09-18T21:26:25Z
_version_	1777412221369843712

Understanding evolutionary processes in bird species using genome-wide sequence analysis

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