Ultra-Morphological Changes of Trichophyton Rubrum Treated with Hydroxychavicol

Trichophyton rubrum is a common pathogenic fungal species that is responsible for causing infection on human skin, hair and nail. The antifungal-resistant strains complicate the treatment regime. Hydroxychavicol (HC) is one of the main compounds from Piper betel leaf that have antifungal potential a...

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Main Authors:	Ridzuan, P. M., Mohamad, Nasir, Ismail, Salwani, A. Rahman, Nor Iza, Sanusi, N. A., Umar, Rabiatul Adawiyah, Hamzah, Hairul Aini, Buyong, Zunariah, Mohd Hassan, Norazian, Baharudin, Roesnita
Format:	Article
Language:	English English
Published:	International Islamic University Malaysia 2017
Subjects:	QR Microbiology
Online Access:	http://irep.iium.edu.my/60896/ http://irep.iium.edu.my/60896/1/IMJM-Vol16-No2-6571.pdf http://irep.iium.edu.my/60896/7/60896_ultra-morphological%20changes_scopus.pdf

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recordtype	eprints
spelling	iium-608962018-01-12T11:24:05Z http://irep.iium.edu.my/60896/ Ultra-Morphological Changes of Trichophyton Rubrum Treated with Hydroxychavicol Ridzuan, P. M. Mohamad, Nasir Ismail, Salwani A. Rahman, Nor Iza Sanusi, N. A. Umar, Rabiatul Adawiyah Hamzah, Hairul Aini Buyong, Zunariah Mohd Hassan, Norazian Baharudin, Roesnita QR Microbiology Trichophyton rubrum is a common pathogenic fungal species that is responsible for causing infection on human skin, hair and nail. The antifungal-resistant strains complicate the treatment regime. Hydroxychavicol (HC) is one of the main compounds from Piper betel leaf that have antifungal potential and its mechanism of action has not been studied yet. The objective of this preliminary study to determine the antifungal properties of HC against T. rubrum using transmission electron microscope (TEM) on gross and ultrastructure of T. rubrum hypha. T. rubrum was treated with HC and miconazole (MI) at concentrations of 1.25, 2.5, 5 and 10 mg/mL for 1, 3, 5 and 7 days continuously. Generally, fungi structures became more severely damaged at increasing treatment duration. Microscopically, the fungi’s cell wall treated with HC showed a rough surface, shrinkage and demolition similar to the MI treated group. The fungi organelles were also demolished and disorganized. This study revealed that HC has the ability to inhibit T. rubrum growth and has potential to be an antifungal agent for skin infections. International Islamic University Malaysia 2017-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/60896/1/IMJM-Vol16-No2-6571.pdf application/pdf en http://irep.iium.edu.my/60896/7/60896_ultra-morphological%20changes_scopus.pdf Ridzuan, P. M. and Mohamad, Nasir and Ismail, Salwani and A. Rahman, Nor Iza and Sanusi, N. A. and Umar, Rabiatul Adawiyah and Hamzah, Hairul Aini and Buyong, Zunariah and Mohd Hassan, Norazian and Baharudin, Roesnita (2017) Ultra-Morphological Changes of Trichophyton Rubrum Treated with Hydroxychavicol. International Medical Journal Malaysia, 16 (2). pp. 65-71. ISSN 1823-4631 E-ISSN 1823-4631
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QR Microbiology
spellingShingle	QR Microbiology Ridzuan, P. M. Mohamad, Nasir Ismail, Salwani A. Rahman, Nor Iza Sanusi, N. A. Umar, Rabiatul Adawiyah Hamzah, Hairul Aini Buyong, Zunariah Mohd Hassan, Norazian Baharudin, Roesnita Ultra-Morphological Changes of Trichophyton Rubrum Treated with Hydroxychavicol
description	Trichophyton rubrum is a common pathogenic fungal species that is responsible for causing infection on human skin, hair and nail. The antifungal-resistant strains complicate the treatment regime. Hydroxychavicol (HC) is one of the main compounds from Piper betel leaf that have antifungal potential and its mechanism of action has not been studied yet. The objective of this preliminary study to determine the antifungal properties of HC against T. rubrum using transmission electron microscope (TEM) on gross and ultrastructure of T. rubrum hypha. T. rubrum was treated with HC and miconazole (MI) at concentrations of 1.25, 2.5, 5 and 10 mg/mL for 1, 3, 5 and 7 days continuously. Generally, fungi structures became more severely damaged at increasing treatment duration. Microscopically, the fungi’s cell wall treated with HC showed a rough surface, shrinkage and demolition similar to the MI treated group. The fungi organelles were also demolished and disorganized. This study revealed that HC has the ability to inhibit T. rubrum growth and has potential to be an antifungal agent for skin infections.
format	Article
author	Ridzuan, P. M. Mohamad, Nasir Ismail, Salwani A. Rahman, Nor Iza Sanusi, N. A. Umar, Rabiatul Adawiyah Hamzah, Hairul Aini Buyong, Zunariah Mohd Hassan, Norazian Baharudin, Roesnita
author_facet	Ridzuan, P. M. Mohamad, Nasir Ismail, Salwani A. Rahman, Nor Iza Sanusi, N. A. Umar, Rabiatul Adawiyah Hamzah, Hairul Aini Buyong, Zunariah Mohd Hassan, Norazian Baharudin, Roesnita
author_sort	Ridzuan, P. M.
title	Ultra-Morphological Changes of Trichophyton Rubrum Treated with Hydroxychavicol
title_short	Ultra-Morphological Changes of Trichophyton Rubrum Treated with Hydroxychavicol
title_full	Ultra-Morphological Changes of Trichophyton Rubrum Treated with Hydroxychavicol
title_fullStr	Ultra-Morphological Changes of Trichophyton Rubrum Treated with Hydroxychavicol
title_full_unstemmed	Ultra-Morphological Changes of Trichophyton Rubrum Treated with Hydroxychavicol
title_sort	ultra-morphological changes of trichophyton rubrum treated with hydroxychavicol
publisher	International Islamic University Malaysia
publishDate	2017
url	http://irep.iium.edu.my/60896/ http://irep.iium.edu.my/60896/1/IMJM-Vol16-No2-6571.pdf http://irep.iium.edu.my/60896/7/60896_ultra-morphological%20changes_scopus.pdf
first_indexed	2023-09-18T21:26:21Z
last_indexed	2023-09-18T21:26:21Z
_version_	1777412217263620096

Ultra-Morphological Changes of Trichophyton Rubrum Treated with Hydroxychavicol

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