Antioxidant and antidiabetic effects of flavonoids: a structure-activity relationship based study

The best described pharmacological property of flavonoids is their capacity to act as potent antioxidant that has been reported to play an important role in the alleviation of diabetes mellitus. Flavonoids biochemical properties are structure dependent; however, they are yet to be thoroughly underst...

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Main Authors:	Sarian, Murni Nazira, Ahmed, Qamar Uddin, Mat So'ad, Siti Zaiton, Alhassan, Alhassan Muhammad, Murugesu, Suganya, Perumal, Vikneswari, Khatib, Alfi, Latip, Jalifah
Format:	Article
Language:	English English
Published:	Hindawi Publishing Corporation 2017
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/60855/ http://irep.iium.edu.my/60855/ http://irep.iium.edu.my/60855/ http://irep.iium.edu.my/60855/1/Murni%20article%201_BioMed%20Research%20International%202017.pdf http://irep.iium.edu.my/60855/7/60855_Antioxidant%20and%20antidiabetic%20effects%20of%20flavonoids_SCOPUS.pdf

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spelling	iium-608552018-04-03T00:53:40Z http://irep.iium.edu.my/60855/ Antioxidant and antidiabetic effects of flavonoids: a structure-activity relationship based study Sarian, Murni Nazira Ahmed, Qamar Uddin Mat So'ad, Siti Zaiton Alhassan, Alhassan Muhammad Murugesu, Suganya Perumal, Vikneswari Khatib, Alfi Latip, Jalifah QD Chemistry The best described pharmacological property of flavonoids is their capacity to act as potent antioxidant that has been reported to play an important role in the alleviation of diabetes mellitus. Flavonoids biochemical properties are structure dependent; however, they are yet to be thoroughly understood. Hence, the main aim of this work was to investigate the antioxidant and antidiabetic properties of some structurally related flavonoids to identify key positions responsible, their correlation, and the effect of methylation and acetylation on the same properties. Antioxidant potential was evaluated through dot blot, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, ABTS+ radical scavenging, ferric reducing antioxidant power (FRAP), and xanthine oxidase inhibitory (XOI) assays. Antidiabetic effect was investigated through α-glucosidase and dipeptidyl peptidase-4 (DPP-4) assays. Results showed that the total number and the configuration of hydroxyl groups played an important role in regulating antioxidant and antidiabetic properties in scavenging DPPH radical, ABTS+ radical, and FRAP assays and improved both α-glucosidase and DPP-4 activities. Presence of C-2-C-3 double bond and C-4 ketonic group are two essential structural features in the bioactivity of flavonoids especially for antidiabetic property. Methylation and acetylation of hydroxyl groups were found to diminish the in vitro antioxidant and antidiabetic properties of the flavonoids. Hindawi Publishing Corporation 2017-12-20 Article PeerReviewed application/pdf en http://irep.iium.edu.my/60855/1/Murni%20article%201_BioMed%20Research%20International%202017.pdf application/pdf en http://irep.iium.edu.my/60855/7/60855_Antioxidant%20and%20antidiabetic%20effects%20of%20flavonoids_SCOPUS.pdf Sarian, Murni Nazira and Ahmed, Qamar Uddin and Mat So'ad, Siti Zaiton and Alhassan, Alhassan Muhammad and Murugesu, Suganya and Perumal, Vikneswari and Khatib, Alfi and Latip, Jalifah (2017) Antioxidant and antidiabetic effects of flavonoids: a structure-activity relationship based study. BioMed Research International, 2017. pp. 1-14. ISSN 2314-6133 E-ISSN 2314-6141 https://www.hindawi.com/journals/bmri/2017/8386065/ 10.1155/2017/8386065
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QD Chemistry
spellingShingle	QD Chemistry Sarian, Murni Nazira Ahmed, Qamar Uddin Mat So'ad, Siti Zaiton Alhassan, Alhassan Muhammad Murugesu, Suganya Perumal, Vikneswari Khatib, Alfi Latip, Jalifah Antioxidant and antidiabetic effects of flavonoids: a structure-activity relationship based study
description	The best described pharmacological property of flavonoids is their capacity to act as potent antioxidant that has been reported to play an important role in the alleviation of diabetes mellitus. Flavonoids biochemical properties are structure dependent; however, they are yet to be thoroughly understood. Hence, the main aim of this work was to investigate the antioxidant and antidiabetic properties of some structurally related flavonoids to identify key positions responsible, their correlation, and the effect of methylation and acetylation on the same properties. Antioxidant potential was evaluated through dot blot, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, ABTS+ radical scavenging, ferric reducing antioxidant power (FRAP), and xanthine oxidase inhibitory (XOI) assays. Antidiabetic effect was investigated through α-glucosidase and dipeptidyl peptidase-4 (DPP-4) assays. Results showed that the total number and the configuration of hydroxyl groups played an important role in regulating antioxidant and antidiabetic properties in scavenging DPPH radical, ABTS+ radical, and FRAP assays and improved both α-glucosidase and DPP-4 activities. Presence of C-2-C-3 double bond and C-4 ketonic group are two essential structural features in the bioactivity of flavonoids especially for antidiabetic property. Methylation and acetylation of hydroxyl groups were found to diminish the in vitro antioxidant and antidiabetic properties of the flavonoids.
format	Article
author	Sarian, Murni Nazira Ahmed, Qamar Uddin Mat So'ad, Siti Zaiton Alhassan, Alhassan Muhammad Murugesu, Suganya Perumal, Vikneswari Khatib, Alfi Latip, Jalifah
author_facet	Sarian, Murni Nazira Ahmed, Qamar Uddin Mat So'ad, Siti Zaiton Alhassan, Alhassan Muhammad Murugesu, Suganya Perumal, Vikneswari Khatib, Alfi Latip, Jalifah
author_sort	Sarian, Murni Nazira
title	Antioxidant and antidiabetic effects of flavonoids: a structure-activity relationship based study
title_short	Antioxidant and antidiabetic effects of flavonoids: a structure-activity relationship based study
title_full	Antioxidant and antidiabetic effects of flavonoids: a structure-activity relationship based study
title_fullStr	Antioxidant and antidiabetic effects of flavonoids: a structure-activity relationship based study
title_full_unstemmed	Antioxidant and antidiabetic effects of flavonoids: a structure-activity relationship based study
title_sort	antioxidant and antidiabetic effects of flavonoids: a structure-activity relationship based study
publisher	Hindawi Publishing Corporation
publishDate	2017
url	http://irep.iium.edu.my/60855/ http://irep.iium.edu.my/60855/ http://irep.iium.edu.my/60855/ http://irep.iium.edu.my/60855/1/Murni%20article%201_BioMed%20Research%20International%202017.pdf http://irep.iium.edu.my/60855/7/60855_Antioxidant%20and%20antidiabetic%20effects%20of%20flavonoids_SCOPUS.pdf
first_indexed	2023-09-18T21:26:16Z
last_indexed	2023-09-18T21:26:16Z
_version_	1777412212741111808

Antioxidant and antidiabetic effects of flavonoids: a structure-activity relationship based study

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