Toxicity studies of agarwood essential oil in vero cells using electrical impedance sensor

Natural products have traditionally been used for medicinal purposes in Asian communities. Toxicity studies typically use animal testing to predict the harmfulness of a particular substance to human health. For this study, in lieu of animal testing, we utilized cell-based biosensors to evaluate the...

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Main Authors:	Mohd Mansor, Ahmad Fairuzabadi, Abbas, Phirdaous, Hamdan, Taufik Hakim, Hashim, Yumi Zuhanis Has-Yun, Nordin, Anis Nurashikin
Format:	Article
Language:	English
Published:	UTM Press 2017
Subjects:	TK7800 Electronics. Computer engineering. Computer hardware. Photoelectronic devices
Online Access:	http://irep.iium.edu.my/60579/ http://irep.iium.edu.my/60579/1/841-3332-1-PB.pdf

id	iium-60579
recordtype	eprints
spelling	iium-605792018-01-11T02:38:18Z http://irep.iium.edu.my/60579/ Toxicity studies of agarwood essential oil in vero cells using electrical impedance sensor Mohd Mansor, Ahmad Fairuzabadi Abbas, Phirdaous Hamdan, Taufik Hakim Hashim, Yumi Zuhanis Has-Yun Nordin, Anis Nurashikin TK7800 Electronics. Computer engineering. Computer hardware. Photoelectronic devices Natural products have traditionally been used for medicinal purposes in Asian communities. Toxicity studies typically use animal testing to predict the harmfulness of a particular substance to human health. For this study, in lieu of animal testing, we utilized cell-based biosensors to evaluate the toxicity of natural products. The cell-based biosensors were fabricated on a printed circuit board with copper electrodes and equipped with PDMS cell culture chambers. Two different electrodes (interdigitated and circular) were designed. Vero cells were used to represent normal healthy cells. The cells were first cultured on the biosensors and then inoculated with natural products, Taxol (chemo drug – positive control), and DMSO (negative control). Impedances of these biosensors were afterwards recorded at six-hour intervals for 80 hours to determine the growth of the cells. It was found that as compared to Taxol, natural products have substantially low toxicant values. UTM Press 2017-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/60579/1/841-3332-1-PB.pdf Mohd Mansor, Ahmad Fairuzabadi and Abbas, Phirdaous and Hamdan, Taufik Hakim and Hashim, Yumi Zuhanis Has-Yun and Nordin, Anis Nurashikin (2017) Toxicity studies of agarwood essential oil in vero cells using electrical impedance sensor. Malaysian Journal of Fundamental and Applied Sciences. pp. 540-545. ISSN 2289-5981 E-ISSN 2289-599X
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	TK7800 Electronics. Computer engineering. Computer hardware. Photoelectronic devices
spellingShingle	TK7800 Electronics. Computer engineering. Computer hardware. Photoelectronic devices Mohd Mansor, Ahmad Fairuzabadi Abbas, Phirdaous Hamdan, Taufik Hakim Hashim, Yumi Zuhanis Has-Yun Nordin, Anis Nurashikin Toxicity studies of agarwood essential oil in vero cells using electrical impedance sensor
description	Natural products have traditionally been used for medicinal purposes in Asian communities. Toxicity studies typically use animal testing to predict the harmfulness of a particular substance to human health. For this study, in lieu of animal testing, we utilized cell-based biosensors to evaluate the toxicity of natural products. The cell-based biosensors were fabricated on a printed circuit board with copper electrodes and equipped with PDMS cell culture chambers. Two different electrodes (interdigitated and circular) were designed. Vero cells were used to represent normal healthy cells. The cells were first cultured on the biosensors and then inoculated with natural products, Taxol (chemo drug – positive control), and DMSO (negative control). Impedances of these biosensors were afterwards recorded at six-hour intervals for 80 hours to determine the growth of the cells. It was found that as compared to Taxol, natural products have substantially low toxicant values.
format	Article
author	Mohd Mansor, Ahmad Fairuzabadi Abbas, Phirdaous Hamdan, Taufik Hakim Hashim, Yumi Zuhanis Has-Yun Nordin, Anis Nurashikin
author_facet	Mohd Mansor, Ahmad Fairuzabadi Abbas, Phirdaous Hamdan, Taufik Hakim Hashim, Yumi Zuhanis Has-Yun Nordin, Anis Nurashikin
author_sort	Mohd Mansor, Ahmad Fairuzabadi
title	Toxicity studies of agarwood essential oil in vero cells using electrical impedance sensor
title_short	Toxicity studies of agarwood essential oil in vero cells using electrical impedance sensor
title_full	Toxicity studies of agarwood essential oil in vero cells using electrical impedance sensor
title_fullStr	Toxicity studies of agarwood essential oil in vero cells using electrical impedance sensor
title_full_unstemmed	Toxicity studies of agarwood essential oil in vero cells using electrical impedance sensor
title_sort	toxicity studies of agarwood essential oil in vero cells using electrical impedance sensor
publisher	UTM Press
publishDate	2017
url	http://irep.iium.edu.my/60579/ http://irep.iium.edu.my/60579/1/841-3332-1-PB.pdf
first_indexed	2023-09-18T21:25:53Z
last_indexed	2023-09-18T21:25:53Z
_version_	1777412187874131968

Toxicity studies of agarwood essential oil in vero cells using electrical impedance sensor

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