Rheological characterization of gelling polymers for pharmaceutical dosage forms

Objective: This study aimed to characterize several gelling polymers as candidates to be developed as pharmaceutical vehicles. Significance: This study opens up more options for pharmaceutical semi-solid vehicle formulator to choose regarding the range of gelling polymers, as the vehicle for their...

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Main Authors:	Abdul Qader, Omar Abdul Jabbar, Doolaanea, Abd Almonem, Abdul Rahman, Mohammad Nasrin, Sukmasari, Susi, Ismail, Ahmad Faisal, khashman, Basim M.
Format:	Conference or Workshop Item
Language:	English
Published:	2017
Subjects:	Q Science (General) RK Dentistry RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology
Online Access:	http://irep.iium.edu.my/60567/ http://irep.iium.edu.my/60567/ http://irep.iium.edu.my/60567/1/60567_Rheological%20characterization%20of%20gelling%20polymers.pdf

id	iium-60567
recordtype	eprints
spelling	iium-605672018-01-23T07:37:53Z http://irep.iium.edu.my/60567/ Rheological characterization of gelling polymers for pharmaceutical dosage forms Abdul Qader, Omar Abdul Jabbar Doolaanea, Abd Almonem Abdul Rahman, Mohammad Nasrin Sukmasari, Susi Ismail, Ahmad Faisal khashman, Basim M. Q Science (General) RK Dentistry RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology Objective: This study aimed to characterize several gelling polymers as candidates to be developed as pharmaceutical vehicles. Significance: This study opens up more options for pharmaceutical semi-solid vehicle formulator to choose regarding the range of gelling polymers, as the vehicle for their pharmaceutical active ingredients. Methods: Five types of gelling polymers (acacia gum, methocel K100M, kelcogel LT100, lambda carrageenan, and locust bean gum) which consist of three different concentrations each, were prepared. The rheological profiles were measured using rheometers, and the data was analyzed to compare their apparent viscosities at various shear rates as well as rheological modelling. Results: At shear rates of 10 s-1, 50 s-1, and 100 s-1, 3% and 5% of kelcogel LT100 as well as 3% and 5% of methocel K100M possessed significantly the highest mean apparent viscosity (Pas). Acacia gum at concentration of 1%, 3% and 5% exhibited the lowest mean apparent viscosity (Pas) (p > 0.05). Each gel possessed different rheological modeling in different concentration, except for lambda carrageenan which possessed Ostwald De-Walele modelling in all concentrations. Among the gel with good regressions, kelcogel LT100 (1% and 5%) had the highest yield stress. Lambda carrageenan (5%) was found to be the most pseudoplastic based on its lowest flow behaviour index (n), and it also possessed the highest consistency factor (k) value. Conclusion: All the rheological profiles for each of the gels at three different concentrations were successfully characterized, analyzed and documented. 2017-11-28 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/60567/1/60567_Rheological%20characterization%20of%20gelling%20polymers.pdf Abdul Qader, Omar Abdul Jabbar and Doolaanea, Abd Almonem and Abdul Rahman, Mohammad Nasrin and Sukmasari, Susi and Ismail, Ahmad Faisal and khashman, Basim M. (2017) Rheological characterization of gelling polymers for pharmaceutical dosage forms. In: Conference on Biomedical and Advanced Materials (Bio-Cam) 2017, 28th-29th November 2017, Bayview Hotel, Langkawi, Malaysia. (Unpublished) https://www.biocam2017.com/organiser
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	Q Science (General) RK Dentistry RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology
spellingShingle	Q Science (General) RK Dentistry RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology Abdul Qader, Omar Abdul Jabbar Doolaanea, Abd Almonem Abdul Rahman, Mohammad Nasrin Sukmasari, Susi Ismail, Ahmad Faisal khashman, Basim M. Rheological characterization of gelling polymers for pharmaceutical dosage forms
description	Objective: This study aimed to characterize several gelling polymers as candidates to be developed as pharmaceutical vehicles. Significance: This study opens up more options for pharmaceutical semi-solid vehicle formulator to choose regarding the range of gelling polymers, as the vehicle for their pharmaceutical active ingredients. Methods: Five types of gelling polymers (acacia gum, methocel K100M, kelcogel LT100, lambda carrageenan, and locust bean gum) which consist of three different concentrations each, were prepared. The rheological profiles were measured using rheometers, and the data was analyzed to compare their apparent viscosities at various shear rates as well as rheological modelling. Results: At shear rates of 10 s-1, 50 s-1, and 100 s-1, 3% and 5% of kelcogel LT100 as well as 3% and 5% of methocel K100M possessed significantly the highest mean apparent viscosity (Pas). Acacia gum at concentration of 1%, 3% and 5% exhibited the lowest mean apparent viscosity (Pas) (p > 0.05). Each gel possessed different rheological modeling in different concentration, except for lambda carrageenan which possessed Ostwald De-Walele modelling in all concentrations. Among the gel with good regressions, kelcogel LT100 (1% and 5%) had the highest yield stress. Lambda carrageenan (5%) was found to be the most pseudoplastic based on its lowest flow behaviour index (n), and it also possessed the highest consistency factor (k) value. Conclusion: All the rheological profiles for each of the gels at three different concentrations were successfully characterized, analyzed and documented.
format	Conference or Workshop Item
author	Abdul Qader, Omar Abdul Jabbar Doolaanea, Abd Almonem Abdul Rahman, Mohammad Nasrin Sukmasari, Susi Ismail, Ahmad Faisal khashman, Basim M.
author_facet	Abdul Qader, Omar Abdul Jabbar Doolaanea, Abd Almonem Abdul Rahman, Mohammad Nasrin Sukmasari, Susi Ismail, Ahmad Faisal khashman, Basim M.
author_sort	Abdul Qader, Omar Abdul Jabbar
title	Rheological characterization of gelling polymers for pharmaceutical dosage forms
title_short	Rheological characterization of gelling polymers for pharmaceutical dosage forms
title_full	Rheological characterization of gelling polymers for pharmaceutical dosage forms
title_fullStr	Rheological characterization of gelling polymers for pharmaceutical dosage forms
title_full_unstemmed	Rheological characterization of gelling polymers for pharmaceutical dosage forms
title_sort	rheological characterization of gelling polymers for pharmaceutical dosage forms
publishDate	2017
url	http://irep.iium.edu.my/60567/ http://irep.iium.edu.my/60567/ http://irep.iium.edu.my/60567/1/60567_Rheological%20characterization%20of%20gelling%20polymers.pdf
first_indexed	2023-09-18T21:25:51Z
last_indexed	2023-09-18T21:25:51Z
_version_	1777412186478477312

Rheological characterization of gelling polymers for pharmaceutical dosage forms

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