In vivo study of the pharmacokinetic effect of amlodipine and gliclazide

It was found that there is kind of pharmacodynamic interaction between calcium channels blockers and sulfonylurea. The addition of amlodipine (AMLO) to gliclazide (GLZ) course caused significant decrease in glucose lowering effect of GLZ. The mechanism of AMLO-GLZ interaction is not well understood....

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Main Authors:	Helaluddin, Abul Bashar Mohammed, Alaama, Mohammed, Awang, Mohamed, Abbas, Syed Atif
Format:	Conference or Workshop Item
Language:	English
Published:	Centre of Lipids Engineering and Applied Research (CLEAR), Universiti Teknologi Malaysia (UTM) 2017
Subjects:	QD Chemistry RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry
Online Access:	http://irep.iium.edu.my/60342/ http://irep.iium.edu.my/60342/ http://irep.iium.edu.my/60342/1/ICOST%202017.pdf

id	iium-60342
recordtype	eprints
spelling	iium-603422017-12-27T02:31:42Z http://irep.iium.edu.my/60342/ In vivo study of the pharmacokinetic effect of amlodipine and gliclazide Helaluddin, Abul Bashar Mohammed Alaama, Mohammed Awang, Mohamed Abbas, Syed Atif QD Chemistry RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry It was found that there is kind of pharmacodynamic interaction between calcium channels blockers and sulfonylurea. The addition of amlodipine (AMLO) to gliclazide (GLZ) course caused significant decrease in glucose lowering effect of GLZ. The mechanism of AMLO-GLZ interaction is not well understood. There is a possibility that this interaction can be a result of pharmacokinetic interaction of both drugs; therefore, this study was designed to investigate the pharmacokinetic interaction between AMLO and GLZ in animal model. The pharmacokinetic interaction was evaluated using Sprauge Dawly rates as they were divided into three groups. The controle group received saline and the gliclazide groupe received gliclazide orally in the dose of 1.44 mg/kg, while the Amlo-Gliclazide groupe has received amlodipine and gliclazide orally with a dose of 0.09 mg/kg and 1.44 mg/kg respectively. After dosing, animals were anesthetized and the blood was collected using retro orbital blood collection method after 1, 2, 4, 6, 8, 12, 24 hours of the dose. A new and novel LC-MS/MS method was developed and validated for the determination of GLZ in and rat plasma. The results showed that the pharmacokinetic parameters such as Cmax (ng/ml), Tmax (hr) were not altered significantly by AMLO administration. However, the administration of AMLO lead to significant increase (p = 0.000672) in AUC. In conclusion the plasma GLZ concentration increased when it was co administered with AMLO, while Cmax and Tmax remain unchanged. This study suggests that AMLO might reduce GLZ elimination. Centre of Lipids Engineering and Applied Research (CLEAR), Universiti Teknologi Malaysia (UTM) 2017-04 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/60342/1/ICOST%202017.pdf Helaluddin, Abul Bashar Mohammed and Alaama, Mohammed and Awang, Mohamed and Abbas, Syed Atif (2017) In vivo study of the pharmacokinetic effect of amlodipine and gliclazide. In: 2nd International Conferenec on Separation Technology (ICoST) 2017, 15th-16th April 2017, Johor Bharu, Johor. https://clear.utm.my/icost2017/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QD Chemistry RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry
spellingShingle	QD Chemistry RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry Helaluddin, Abul Bashar Mohammed Alaama, Mohammed Awang, Mohamed Abbas, Syed Atif In vivo study of the pharmacokinetic effect of amlodipine and gliclazide
description	It was found that there is kind of pharmacodynamic interaction between calcium channels blockers and sulfonylurea. The addition of amlodipine (AMLO) to gliclazide (GLZ) course caused significant decrease in glucose lowering effect of GLZ. The mechanism of AMLO-GLZ interaction is not well understood. There is a possibility that this interaction can be a result of pharmacokinetic interaction of both drugs; therefore, this study was designed to investigate the pharmacokinetic interaction between AMLO and GLZ in animal model. The pharmacokinetic interaction was evaluated using Sprauge Dawly rates as they were divided into three groups. The controle group received saline and the gliclazide groupe received gliclazide orally in the dose of 1.44 mg/kg, while the Amlo-Gliclazide groupe has received amlodipine and gliclazide orally with a dose of 0.09 mg/kg and 1.44 mg/kg respectively. After dosing, animals were anesthetized and the blood was collected using retro orbital blood collection method after 1, 2, 4, 6, 8, 12, 24 hours of the dose. A new and novel LC-MS/MS method was developed and validated for the determination of GLZ in and rat plasma. The results showed that the pharmacokinetic parameters such as Cmax (ng/ml), Tmax (hr) were not altered significantly by AMLO administration. However, the administration of AMLO lead to significant increase (p = 0.000672) in AUC. In conclusion the plasma GLZ concentration increased when it was co administered with AMLO, while Cmax and Tmax remain unchanged. This study suggests that AMLO might reduce GLZ elimination.
format	Conference or Workshop Item
author	Helaluddin, Abul Bashar Mohammed Alaama, Mohammed Awang, Mohamed Abbas, Syed Atif
author_facet	Helaluddin, Abul Bashar Mohammed Alaama, Mohammed Awang, Mohamed Abbas, Syed Atif
author_sort	Helaluddin, Abul Bashar Mohammed
title	In vivo study of the pharmacokinetic effect of amlodipine and gliclazide
title_short	In vivo study of the pharmacokinetic effect of amlodipine and gliclazide
title_full	In vivo study of the pharmacokinetic effect of amlodipine and gliclazide
title_fullStr	In vivo study of the pharmacokinetic effect of amlodipine and gliclazide
title_full_unstemmed	In vivo study of the pharmacokinetic effect of amlodipine and gliclazide
title_sort	in vivo study of the pharmacokinetic effect of amlodipine and gliclazide
publisher	Centre of Lipids Engineering and Applied Research (CLEAR), Universiti Teknologi Malaysia (UTM)
publishDate	2017
url	http://irep.iium.edu.my/60342/ http://irep.iium.edu.my/60342/ http://irep.iium.edu.my/60342/1/ICOST%202017.pdf
first_indexed	2023-09-18T21:25:32Z
last_indexed	2023-09-18T21:25:32Z
_version_	1777412166191677440

In vivo study of the pharmacokinetic effect of amlodipine and gliclazide

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