A porous medium-chain-length poly(3-hydroxyalkanoates)/hydroxyapatite composite as scaffold for bone tissue engineering
Polyhydroxyalkanoates (PHA) are hydrophobic biopolymers with huge potential for biomedical applications due to their biocompatibility, excellent mechanical properties and biodegradability. A porous composite scaffold made of mediumchain- length poly(3-hydroxyalkanoates) (mcl-PHA) and hydroxyapati...
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Wiley-VCH Verlag
2017
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| Online Access: | http://irep.iium.edu.my/60336/ http://irep.iium.edu.my/60336/ http://irep.iium.edu.my/60336/7/60336_A%20porous%20medium-chain-length_article.pdf http://irep.iium.edu.my/60336/8/60336_A%20porous%20medium-chain-length_scopus.pdf |
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iium-603362018-06-21T00:57:08Z http://irep.iium.edu.my/60336/ A porous medium-chain-length poly(3-hydroxyalkanoates)/hydroxyapatite composite as scaffold for bone tissue engineering Ansari, Nor Faezah Annuar, Mohamad Suffian Murphy, Belinda-pingguan QH301 Biology Polyhydroxyalkanoates (PHA) are hydrophobic biopolymers with huge potential for biomedical applications due to their biocompatibility, excellent mechanical properties and biodegradability. A porous composite scaffold made of mediumchain- length poly(3-hydroxyalkanoates) (mcl-PHA) and hydroxyapatite (HA) was fabricated using particulate leaching technique and NaCl as a porogen. Different percentages of HA loading was investigated that would support the growth of osteoblast cells. Ultrasonic irradiation was applied to facilitate the dispersion of HA particles into the mcl-PHA matrix. The different P(3HO-co-3HHX)/HA composites were investigated using field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD) and energy dispersive X-ray analysis (EDXA). The scaffolds were found to be highly porous with interconnecting pore structures and the HA particles were homogeneously dispersed in the polymer matrix. The scaffolds biocompatibility and osteoconductivity were also assessed following the proliferation and differentiation of osteoblast cells on the scaffolds. From the results, it is clear that scaffolds made from P(3HO-co-3HHX)/HA composites are viable candidate materials for bone tissue engineering applications. Wiley-VCH Verlag 2017-04-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/60336/7/60336_A%20porous%20medium-chain-length_article.pdf application/pdf en http://irep.iium.edu.my/60336/8/60336_A%20porous%20medium-chain-length_scopus.pdf Ansari, Nor Faezah and Annuar, Mohamad Suffian and Murphy, Belinda-pingguan (2017) A porous medium-chain-length poly(3-hydroxyalkanoates)/hydroxyapatite composite as scaffold for bone tissue engineering. Engineering in Life Sciences, 17 (4). pp. 420-429. ISSN 1618-0240 E-ISSN 1618-2863 http://onlinelibrary.wiley.com/doi/10.1002/elsc.201600084/abstract |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English English |
| topic |
QH301 Biology |
| spellingShingle |
QH301 Biology Ansari, Nor Faezah Annuar, Mohamad Suffian Murphy, Belinda-pingguan A porous medium-chain-length poly(3-hydroxyalkanoates)/hydroxyapatite composite as scaffold for bone tissue engineering |
| description |
Polyhydroxyalkanoates (PHA) are hydrophobic biopolymers with huge potential
for biomedical applications due to their biocompatibility, excellent mechanical
properties and biodegradability. A porous composite scaffold made of mediumchain-
length poly(3-hydroxyalkanoates) (mcl-PHA) and hydroxyapatite (HA) was
fabricated using particulate leaching technique and NaCl as a porogen. Different
percentages of HA loading was investigated that would support the growth of osteoblast
cells. Ultrasonic irradiation was applied to facilitate the dispersion of HA
particles into the mcl-PHA matrix. The different P(3HO-co-3HHX)/HA composites
were investigated using field emission scanning electron microscopy (FESEM),
X-ray diffraction (XRD) and energy dispersive X-ray analysis (EDXA). The scaffolds
were found to be highly porous with interconnecting pore structures and the HA
particles were homogeneously dispersed in the polymer matrix. The scaffolds biocompatibility
and osteoconductivity were also assessed following the proliferation
and differentiation of osteoblast cells on the scaffolds. From the results, it is clear
that scaffolds made from P(3HO-co-3HHX)/HA composites are viable candidate
materials for bone tissue engineering applications. |
| format |
Article |
| author |
Ansari, Nor Faezah Annuar, Mohamad Suffian Murphy, Belinda-pingguan |
| author_facet |
Ansari, Nor Faezah Annuar, Mohamad Suffian Murphy, Belinda-pingguan |
| author_sort |
Ansari, Nor Faezah |
| title |
A porous medium-chain-length
poly(3-hydroxyalkanoates)/hydroxyapatite
composite as scaffold for bone tissue
engineering |
| title_short |
A porous medium-chain-length
poly(3-hydroxyalkanoates)/hydroxyapatite
composite as scaffold for bone tissue
engineering |
| title_full |
A porous medium-chain-length
poly(3-hydroxyalkanoates)/hydroxyapatite
composite as scaffold for bone tissue
engineering |
| title_fullStr |
A porous medium-chain-length
poly(3-hydroxyalkanoates)/hydroxyapatite
composite as scaffold for bone tissue
engineering |
| title_full_unstemmed |
A porous medium-chain-length
poly(3-hydroxyalkanoates)/hydroxyapatite
composite as scaffold for bone tissue
engineering |
| title_sort |
porous medium-chain-length
poly(3-hydroxyalkanoates)/hydroxyapatite
composite as scaffold for bone tissue
engineering |
| publisher |
Wiley-VCH Verlag |
| publishDate |
2017 |
| url |
http://irep.iium.edu.my/60336/ http://irep.iium.edu.my/60336/ http://irep.iium.edu.my/60336/7/60336_A%20porous%20medium-chain-length_article.pdf http://irep.iium.edu.my/60336/8/60336_A%20porous%20medium-chain-length_scopus.pdf |
| first_indexed |
2023-09-18T21:25:31Z |
| last_indexed |
2023-09-18T21:25:31Z |
| _version_ |
1777412165436702720 |