A porous medium-chain-length poly(3-hydroxyalkanoates)/hydroxyapatite composite as scaffold for bone tissue engineering
Polyhydroxyalkanoates (PHA) are hydrophobic biopolymers with huge potential for biomedical applications due to their biocompatibility, excellent mechanical properties and biodegradability. A porous composite scaffold made of mediumchain- length poly(3-hydroxyalkanoates) (mcl-PHA) and hydroxyapati...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Wiley-VCH Verlag
2017
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/60336/ http://irep.iium.edu.my/60336/ http://irep.iium.edu.my/60336/7/60336_A%20porous%20medium-chain-length_article.pdf http://irep.iium.edu.my/60336/8/60336_A%20porous%20medium-chain-length_scopus.pdf |
| Summary: | Polyhydroxyalkanoates (PHA) are hydrophobic biopolymers with huge potential
for biomedical applications due to their biocompatibility, excellent mechanical
properties and biodegradability. A porous composite scaffold made of mediumchain-
length poly(3-hydroxyalkanoates) (mcl-PHA) and hydroxyapatite (HA) was
fabricated using particulate leaching technique and NaCl as a porogen. Different
percentages of HA loading was investigated that would support the growth of osteoblast
cells. Ultrasonic irradiation was applied to facilitate the dispersion of HA
particles into the mcl-PHA matrix. The different P(3HO-co-3HHX)/HA composites
were investigated using field emission scanning electron microscopy (FESEM),
X-ray diffraction (XRD) and energy dispersive X-ray analysis (EDXA). The scaffolds
were found to be highly porous with interconnecting pore structures and the HA
particles were homogeneously dispersed in the polymer matrix. The scaffolds biocompatibility
and osteoconductivity were also assessed following the proliferation
and differentiation of osteoblast cells on the scaffolds. From the results, it is clear
that scaffolds made from P(3HO-co-3HHX)/HA composites are viable candidate
materials for bone tissue engineering applications. |
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