Lysophosphatidylinositol: a novel link between ABC transporters and G-protein-coupled receptors

Lysophosphatidylinositol (LPI) is a well-known bioactive lipid that is able to activate signalling cascades relevant to cell proliferation, migration, survival and tumorigenesis. Our previous work suggested that LPI is involved in cancer progression since it can be released in the medium of Ras-tran...

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Main Authors:	Ruban, Emily L., Ferro, Riccardo, Ahmad Arifin, Syamsul, Falasca, Marco
Format:	Article
Language:	English
Published:	Portland Press Ltd. 2014
Subjects:	RM283 Endocrinotheraphy RM300 Drugs and their action
Online Access:	http://irep.iium.edu.my/60087/ http://irep.iium.edu.my/60087/ http://irep.iium.edu.my/60087/1/Lysophosphatidylinositol%20a%20novel%20link%20between%20ABC%20transporters%20and%20G-protein-coupled%20receptors.pdf

id	iium-60087
recordtype	eprints
spelling	iium-600872017-12-14T08:53:40Z http://irep.iium.edu.my/60087/ Lysophosphatidylinositol: a novel link between ABC transporters and G-protein-coupled receptors Ruban, Emily L. Ferro, Riccardo Ahmad Arifin, Syamsul Falasca, Marco RM283 Endocrinotheraphy RM300 Drugs and their action Lysophosphatidylinositol (LPI) is a well-known bioactive lipid that is able to activate signalling cascades relevant to cell proliferation, migration, survival and tumorigenesis. Our previous work suggested that LPI is involved in cancer progression since it can be released in the medium of Ras-transformed fibroblasts and can function as an autocrine modulator of cell growth. Different research groups have established that LPI is the specific and functional ligand for G-protein-coupled receptor 55 (GPR55) and that this GPR55–LPI axis is able to activate signalling cascades that are relevant for different cell functions. Work in our laboratory has recently unravelled an autocrine loop, by which LPI synthesized by cytosolic phospholipase A2 (cPLA2) is pumped out of the cell by ATP-binding cassette (ABC) transporter C1 (ABCC1)/multidrug resistance protein 1 (MRP1), initiating a signalling cascade downstream of GPR55. Our current work suggests that blockade of this pathway may represent a novel strategy to inhibit cancer cell proliferation. Portland Press Ltd. 2014 Article PeerReviewed application/pdf en http://irep.iium.edu.my/60087/1/Lysophosphatidylinositol%20a%20novel%20link%20between%20ABC%20transporters%20and%20G-protein-coupled%20receptors.pdf Ruban, Emily L. and Ferro, Riccardo and Ahmad Arifin, Syamsul and Falasca, Marco (2014) Lysophosphatidylinositol: a novel link between ABC transporters and G-protein-coupled receptors. Biochemical Society Transactions, 42 (5). pp. 1372-1377. ISSN 0300-5127 E-ISSN 1470-8752 http://www.biochemsoctrans.org/content/42/5/1372
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RM283 Endocrinotheraphy RM300 Drugs and their action
spellingShingle	RM283 Endocrinotheraphy RM300 Drugs and their action Ruban, Emily L. Ferro, Riccardo Ahmad Arifin, Syamsul Falasca, Marco Lysophosphatidylinositol: a novel link between ABC transporters and G-protein-coupled receptors
description	Lysophosphatidylinositol (LPI) is a well-known bioactive lipid that is able to activate signalling cascades relevant to cell proliferation, migration, survival and tumorigenesis. Our previous work suggested that LPI is involved in cancer progression since it can be released in the medium of Ras-transformed fibroblasts and can function as an autocrine modulator of cell growth. Different research groups have established that LPI is the specific and functional ligand for G-protein-coupled receptor 55 (GPR55) and that this GPR55–LPI axis is able to activate signalling cascades that are relevant for different cell functions. Work in our laboratory has recently unravelled an autocrine loop, by which LPI synthesized by cytosolic phospholipase A2 (cPLA2) is pumped out of the cell by ATP-binding cassette (ABC) transporter C1 (ABCC1)/multidrug resistance protein 1 (MRP1), initiating a signalling cascade downstream of GPR55. Our current work suggests that blockade of this pathway may represent a novel strategy to inhibit cancer cell proliferation.
format	Article
author	Ruban, Emily L. Ferro, Riccardo Ahmad Arifin, Syamsul Falasca, Marco
author_facet	Ruban, Emily L. Ferro, Riccardo Ahmad Arifin, Syamsul Falasca, Marco
author_sort	Ruban, Emily L.
title	Lysophosphatidylinositol: a novel link between ABC transporters and G-protein-coupled receptors
title_short	Lysophosphatidylinositol: a novel link between ABC transporters and G-protein-coupled receptors
title_full	Lysophosphatidylinositol: a novel link between ABC transporters and G-protein-coupled receptors
title_fullStr	Lysophosphatidylinositol: a novel link between ABC transporters and G-protein-coupled receptors
title_full_unstemmed	Lysophosphatidylinositol: a novel link between ABC transporters and G-protein-coupled receptors
title_sort	lysophosphatidylinositol: a novel link between abc transporters and g-protein-coupled receptors
publisher	Portland Press Ltd.
publishDate	2014
url	http://irep.iium.edu.my/60087/ http://irep.iium.edu.my/60087/ http://irep.iium.edu.my/60087/1/Lysophosphatidylinositol%20a%20novel%20link%20between%20ABC%20transporters%20and%20G-protein-coupled%20receptors.pdf
first_indexed	2023-09-18T21:25:10Z
last_indexed	2023-09-18T21:25:10Z
_version_	1777412143343206400

Lysophosphatidylinositol: a novel link between ABC transporters and G-protein-coupled receptors

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