Cytokinetic study of uninfected agarwood branch ethanolic extract on breast cancer cells

Breast cancer is the most common malignancy in women with over 500,000 global death toll annually. Ethnopharmaceutical practices provide evidences of Aquilaria spp. as traditional treatment for numerous illness. This study intended to look into the cytotoxic kinetics of uninfected agarwood branch...

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Main Authors:	Abbas, Phirdaous, Hashim, Yumi Zuhanis Has-Yun, Amid, Azura
Format:	Article
Language:	English
Published:	Malaysian Society for Molecular Biology and Biotechnology 2017
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/59729/ http://irep.iium.edu.my/59729/ http://irep.iium.edu.my/59729/1/Paper-Abbas%20et%20al%202017%20%28APJMBB%29.pdf

id	iium-59729
recordtype	eprints
spelling	iium-597292018-01-12T09:32:51Z http://irep.iium.edu.my/59729/ Cytokinetic study of uninfected agarwood branch ethanolic extract on breast cancer cells Abbas, Phirdaous Hashim, Yumi Zuhanis Has-Yun Amid, Azura Q Science (General) Breast cancer is the most common malignancy in women with over 500,000 global death toll annually. Ethnopharmaceutical practices provide evidences of Aquilaria spp. as traditional treatment for numerous illness. This study intended to look into the cytotoxic kinetics of uninfected agarwood branch ethanolic extract from Aquilaria subintegra against MCF-7 breast cancer cell line that could help grasp the effect and provide baseline towards development of agarwood-based therapeutics. Extract was subjected to a series of kinetic studies in order to investigate the growth rate, death rate, doubling time and death time of MCF-7 between the treated and control groups. Results obtained indicated that the extract lowered the growth rate from 0.0421 h-1 to 0.0158 h-1 and stretched the doubling time from 16.4 hours to 43.8 hours. Death rate was escalated from 0.0058 h-1 to 0.0563 h-1. Closer inspection on the population density images revealed that the extract-treated MCF-7 cells showed abnormal appearance with blebs, volume reduction, cell shrinking and loss of cell-cell contact. These discoveries implied that agarwood uninfected branch ethanolic extract altered the kinetics of MCF-7 cells and additional study should be made to substantiate the hypothesis and elucidate the effects against cancer. Malaysian Society for Molecular Biology and Biotechnology 2017-06 Article PeerReviewed application/pdf en http://irep.iium.edu.my/59729/1/Paper-Abbas%20et%20al%202017%20%28APJMBB%29.pdf Abbas, Phirdaous and Hashim, Yumi Zuhanis Has-Yun and Amid, Azura (2017) Cytokinetic study of uninfected agarwood branch ethanolic extract on breast cancer cells. Asia Pacific Journal of Molecular Biology and Biotechnology, 25 (1). pp. 1-7. ISSN 0128-7451 http://www.msmbb.org.my/apjmbb/html251/251h.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	Q Science (General)
spellingShingle	Q Science (General) Abbas, Phirdaous Hashim, Yumi Zuhanis Has-Yun Amid, Azura Cytokinetic study of uninfected agarwood branch ethanolic extract on breast cancer cells
description	Breast cancer is the most common malignancy in women with over 500,000 global death toll annually. Ethnopharmaceutical practices provide evidences of Aquilaria spp. as traditional treatment for numerous illness. This study intended to look into the cytotoxic kinetics of uninfected agarwood branch ethanolic extract from Aquilaria subintegra against MCF-7 breast cancer cell line that could help grasp the effect and provide baseline towards development of agarwood-based therapeutics. Extract was subjected to a series of kinetic studies in order to investigate the growth rate, death rate, doubling time and death time of MCF-7 between the treated and control groups. Results obtained indicated that the extract lowered the growth rate from 0.0421 h-1 to 0.0158 h-1 and stretched the doubling time from 16.4 hours to 43.8 hours. Death rate was escalated from 0.0058 h-1 to 0.0563 h-1. Closer inspection on the population density images revealed that the extract-treated MCF-7 cells showed abnormal appearance with blebs, volume reduction, cell shrinking and loss of cell-cell contact. These discoveries implied that agarwood uninfected branch ethanolic extract altered the kinetics of MCF-7 cells and additional study should be made to substantiate the hypothesis and elucidate the effects against cancer.
format	Article
author	Abbas, Phirdaous Hashim, Yumi Zuhanis Has-Yun Amid, Azura
author_facet	Abbas, Phirdaous Hashim, Yumi Zuhanis Has-Yun Amid, Azura
author_sort	Abbas, Phirdaous
title	Cytokinetic study of uninfected agarwood branch ethanolic extract on breast cancer cells
title_short	Cytokinetic study of uninfected agarwood branch ethanolic extract on breast cancer cells
title_full	Cytokinetic study of uninfected agarwood branch ethanolic extract on breast cancer cells
title_fullStr	Cytokinetic study of uninfected agarwood branch ethanolic extract on breast cancer cells
title_full_unstemmed	Cytokinetic study of uninfected agarwood branch ethanolic extract on breast cancer cells
title_sort	cytokinetic study of uninfected agarwood branch ethanolic extract on breast cancer cells
publisher	Malaysian Society for Molecular Biology and Biotechnology
publishDate	2017
url	http://irep.iium.edu.my/59729/ http://irep.iium.edu.my/59729/ http://irep.iium.edu.my/59729/1/Paper-Abbas%20et%20al%202017%20%28APJMBB%29.pdf
first_indexed	2023-09-18T21:24:38Z
last_indexed	2023-09-18T21:24:38Z
_version_	1777412109114540032

Cytokinetic study of uninfected agarwood branch ethanolic extract on breast cancer cells

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