Identifying “at-risk” patients for sub-optimal beta-lactam exposure in critically ill patients with severe infections

Pathophysiological changes affecting drug pharmacokinetics Mortality due to severe infections in the intensive care unit (ICU) remains high despite recent therapeutic advancements [1]. However, appropriate antibiotic administration (including spectrum of activity and therapeutic exposure) is r...

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Main Authors:	Abdul Aziz, Mohd. Hafiz, Lipman, Jeffrey, Roberts, Jason A.
Format:	Article
Language:	English English
Published:	BioMed Central 2017
Subjects:	RC111 Infectious and Parasitic Diseases RC82 Medical Emergencies, Critical Care, Intensive Care, First Aid RM Therapeutics. Pharmacology RM300 Drugs and their action RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/59680/ http://irep.iium.edu.my/59680/ http://irep.iium.edu.my/59680/ http://irep.iium.edu.my/59680/1/s13054-017-1871-2.pdf http://irep.iium.edu.my/59680/7/Identifying%20%27at-risk%27%20patients%20for%20sub-optimal%20beta-lactam%20exposure%20in%20critically%20ill%20patients%20with%20severe%20infections.pdf

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spelling	iium-596802018-01-16T04:10:06Z http://irep.iium.edu.my/59680/ Identifying “at-risk” patients for sub-optimal beta-lactam exposure in critically ill patients with severe infections Abdul Aziz, Mohd. Hafiz Lipman, Jeffrey Roberts, Jason A. RC111 Infectious and Parasitic Diseases RC82 Medical Emergencies, Critical Care, Intensive Care, First Aid RM Therapeutics. Pharmacology RM300 Drugs and their action RS Pharmacy and materia medica Pathophysiological changes affecting drug pharmacokinetics Mortality due to severe infections in the intensive care unit (ICU) remains high despite recent therapeutic advancements [1]. However, appropriate antibiotic administration (including spectrum of activity and therapeutic exposure) is rarely a straightforward process in ICU patients as they commonly develop extreme pathophysiological changes that can alter antibiotic pharmacokinetics and consequently affect drug exposure in this population. The volume of distribution and drug clearance are the pharmacokinetic parameters of greatest relevance to determining drug dosing requirements, and both parameters may be significantly deranged during critical illness [2, 3]. Furthermore, ICU pathogens are relatively different from those in the general wards as they commonly have reduced antibiotic susceptibility [4]. Despite profound physiological and pharmacokinetic differences to the noncritically ill population, critically ill patients are typically given conventional antibiotic dosing regimens, which increase the likelihood of therapeutic failures and the emergence of bacterial resistance [5]. BioMed Central 2017-11-21 Article PeerReviewed application/pdf en http://irep.iium.edu.my/59680/1/s13054-017-1871-2.pdf application/pdf en http://irep.iium.edu.my/59680/7/Identifying%20%27at-risk%27%20patients%20for%20sub-optimal%20beta-lactam%20exposure%20in%20critically%20ill%20patients%20with%20severe%20infections.pdf Abdul Aziz, Mohd. Hafiz and Lipman, Jeffrey and Roberts, Jason A. (2017) Identifying “at-risk” patients for sub-optimal beta-lactam exposure in critically ill patients with severe infections. Critical Care, 21 (283). pp. 1-3. ISSN 1364-8535 https://ccforum.biomedcentral.com/articles/10.1186/s13054-017-1871-2 10.1186/s13054-017-1871-2
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RC111 Infectious and Parasitic Diseases RC82 Medical Emergencies, Critical Care, Intensive Care, First Aid RM Therapeutics. Pharmacology RM300 Drugs and their action RS Pharmacy and materia medica
spellingShingle	RC111 Infectious and Parasitic Diseases RC82 Medical Emergencies, Critical Care, Intensive Care, First Aid RM Therapeutics. Pharmacology RM300 Drugs and their action RS Pharmacy and materia medica Abdul Aziz, Mohd. Hafiz Lipman, Jeffrey Roberts, Jason A. Identifying “at-risk” patients for sub-optimal beta-lactam exposure in critically ill patients with severe infections
description	Pathophysiological changes affecting drug pharmacokinetics Mortality due to severe infections in the intensive care unit (ICU) remains high despite recent therapeutic advancements [1]. However, appropriate antibiotic administration (including spectrum of activity and therapeutic exposure) is rarely a straightforward process in ICU patients as they commonly develop extreme pathophysiological changes that can alter antibiotic pharmacokinetics and consequently affect drug exposure in this population. The volume of distribution and drug clearance are the pharmacokinetic parameters of greatest relevance to determining drug dosing requirements, and both parameters may be significantly deranged during critical illness [2, 3]. Furthermore, ICU pathogens are relatively different from those in the general wards as they commonly have reduced antibiotic susceptibility [4]. Despite profound physiological and pharmacokinetic differences to the noncritically ill population, critically ill patients are typically given conventional antibiotic dosing regimens, which increase the likelihood of therapeutic failures and the emergence of bacterial resistance [5].
format	Article
author	Abdul Aziz, Mohd. Hafiz Lipman, Jeffrey Roberts, Jason A.
author_facet	Abdul Aziz, Mohd. Hafiz Lipman, Jeffrey Roberts, Jason A.
author_sort	Abdul Aziz, Mohd. Hafiz
title	Identifying “at-risk” patients for sub-optimal beta-lactam exposure in critically ill patients with severe infections
title_short	Identifying “at-risk” patients for sub-optimal beta-lactam exposure in critically ill patients with severe infections
title_full	Identifying “at-risk” patients for sub-optimal beta-lactam exposure in critically ill patients with severe infections
title_fullStr	Identifying “at-risk” patients for sub-optimal beta-lactam exposure in critically ill patients with severe infections
title_full_unstemmed	Identifying “at-risk” patients for sub-optimal beta-lactam exposure in critically ill patients with severe infections
title_sort	identifying “at-risk” patients for sub-optimal beta-lactam exposure in critically ill patients with severe infections
publisher	BioMed Central
publishDate	2017
url	http://irep.iium.edu.my/59680/ http://irep.iium.edu.my/59680/ http://irep.iium.edu.my/59680/ http://irep.iium.edu.my/59680/1/s13054-017-1871-2.pdf http://irep.iium.edu.my/59680/7/Identifying%20%27at-risk%27%20patients%20for%20sub-optimal%20beta-lactam%20exposure%20in%20critically%20ill%20patients%20with%20severe%20infections.pdf
first_indexed	2023-09-18T21:24:33Z
last_indexed	2023-09-18T21:24:33Z
_version_	1777412104395948032

Identifying “at-risk” patients for sub-optimal beta-lactam exposure in critically ill patients with severe infections

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