Anticancer peptides derived from supermeal worm (Zophobas morio) larvae

Cancer still presents enormous challenges in the medical world. Currently, the search for anticancer compounds has garnered a lot of interest, especially in finding them from the natural sources. In this study, by using Sulforhodamine B (SRB) colorimetric assay, compounds, extracted from supermeal w...

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Main Authors:	Yusof, Faridah, Chowdury, Silvia, Faruck, Mohammad Omer, Sulaiman, Nadzril
Format:	Article
Language:	English English
Published:	Universiti Putra Malaysia 2017
Subjects:	TP155 Chemical engineering TP248.13 Biotechnology
Online Access:	http://irep.iium.edu.my/59628/ http://irep.iium.edu.my/59628/ http://irep.iium.edu.my/59628/1/59628_Anticancer%20peptides%20derived%20from%20supermeal.pdf http://irep.iium.edu.my/59628/7/59628_Anticancer%20peptides%20derived%20from%20supermeal%20_scopus.pdf

id	iium-59628
recordtype	eprints
spelling	iium-596282018-06-25T03:57:40Z http://irep.iium.edu.my/59628/ Anticancer peptides derived from supermeal worm (Zophobas morio) larvae Yusof, Faridah Chowdury, Silvia Faruck, Mohammad Omer Sulaiman, Nadzril TP155 Chemical engineering TP248.13 Biotechnology Cancer still presents enormous challenges in the medical world. Currently, the search for anticancer compounds has garnered a lot of interest, especially in finding them from the natural sources. In this study, by using Sulforhodamine B (SRB) colorimetric assay, compounds, extracted from supermeal worm (Zophobas morio) larvae using two types of acidified organic solvent (ethanol and isopropanol), were shown to inhibit the growth of a breast cancer line, MCF-7. A comparative study of the effect was carried out on a normal cell line, Vero. Results showed that, the two types of extracts inhibits growth of MCF-7 cell at varying degrees, on the other hand, have much less effect on Vero cell. Extracts analysed by UV-vis spectroscopy, showed peaks in the range of 260 to 280 nm, inferring the presence of aromatic amino acids, whereas the highest peak of 3.608 AU at 230 nm indicates the presence of peptide bonds. By Raman spectroscopy, peaks are observed at 1349 cm-1, 944 cm-1 and 841 cm-1 indicating the presence of Tyr, Try and Gly, confirming the UV-vis analyses. All results of analyses implied that the anticancer compounds contain peptides. Universiti Putra Malaysia 2017-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/59628/1/59628_Anticancer%20peptides%20derived%20from%20supermeal.pdf application/pdf en http://irep.iium.edu.my/59628/7/59628_Anticancer%20peptides%20derived%20from%20supermeal%20_scopus.pdf Yusof, Faridah and Chowdury, Silvia and Faruck, Mohammad Omer and Sulaiman, Nadzril (2017) Anticancer peptides derived from supermeal worm (Zophobas morio) larvae. International Food Research Journal (IFRJ), 24. S456-S451. ISSN 2231-7546 E-ISSN 2231-7546 http://www.ifrj.upm.edu.my/24%20(07)%202017%20supplementary/(29)%20R1.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	TP155 Chemical engineering TP248.13 Biotechnology
spellingShingle	TP155 Chemical engineering TP248.13 Biotechnology Yusof, Faridah Chowdury, Silvia Faruck, Mohammad Omer Sulaiman, Nadzril Anticancer peptides derived from supermeal worm (Zophobas morio) larvae
description	Cancer still presents enormous challenges in the medical world. Currently, the search for anticancer compounds has garnered a lot of interest, especially in finding them from the natural sources. In this study, by using Sulforhodamine B (SRB) colorimetric assay, compounds, extracted from supermeal worm (Zophobas morio) larvae using two types of acidified organic solvent (ethanol and isopropanol), were shown to inhibit the growth of a breast cancer line, MCF-7. A comparative study of the effect was carried out on a normal cell line, Vero. Results showed that, the two types of extracts inhibits growth of MCF-7 cell at varying degrees, on the other hand, have much less effect on Vero cell. Extracts analysed by UV-vis spectroscopy, showed peaks in the range of 260 to 280 nm, inferring the presence of aromatic amino acids, whereas the highest peak of 3.608 AU at 230 nm indicates the presence of peptide bonds. By Raman spectroscopy, peaks are observed at 1349 cm-1, 944 cm-1 and 841 cm-1 indicating the presence of Tyr, Try and Gly, confirming the UV-vis analyses. All results of analyses implied that the anticancer compounds contain peptides.
format	Article
author	Yusof, Faridah Chowdury, Silvia Faruck, Mohammad Omer Sulaiman, Nadzril
author_facet	Yusof, Faridah Chowdury, Silvia Faruck, Mohammad Omer Sulaiman, Nadzril
author_sort	Yusof, Faridah
title	Anticancer peptides derived from supermeal worm (Zophobas morio) larvae
title_short	Anticancer peptides derived from supermeal worm (Zophobas morio) larvae
title_full	Anticancer peptides derived from supermeal worm (Zophobas morio) larvae
title_fullStr	Anticancer peptides derived from supermeal worm (Zophobas morio) larvae
title_full_unstemmed	Anticancer peptides derived from supermeal worm (Zophobas morio) larvae
title_sort	anticancer peptides derived from supermeal worm (zophobas morio) larvae
publisher	Universiti Putra Malaysia
publishDate	2017
url	http://irep.iium.edu.my/59628/ http://irep.iium.edu.my/59628/ http://irep.iium.edu.my/59628/1/59628_Anticancer%20peptides%20derived%20from%20supermeal.pdf http://irep.iium.edu.my/59628/7/59628_Anticancer%20peptides%20derived%20from%20supermeal%20_scopus.pdf
first_indexed	2023-09-18T21:24:29Z
last_indexed	2023-09-18T21:24:29Z
_version_	1777412099674210304

Anticancer peptides derived from supermeal worm (Zophobas morio) larvae

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