Comparative study between hard bovine gelatin capsule and vegetarian capsule

INTRODUCTION: Objective of this study is to compare in-vitro performance of hard bovine gelatin capsule (BC) and hard vegetarian capsules (VC). Such study is timely for several reasons: 1) to find alternative for animal-origin capsule especially when the issue like Bovine Sponge Encephalitis (BSE)...

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Main Authors:	Mohamed, Farahidah, Paimin, Hafizurrahman, Awang, Mohamed, Abdullah Hazim, Anas
Format:	Conference or Workshop Item
Language:	English
Published:	2011
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/5954/ http://irep.iium.edu.my/5954/ http://irep.iium.edu.my/5954/2/Comparative_Study_between_Hard_Bovine_Gelatin__poster_farahidah_final.pdf

id	iium-5954
recordtype	eprints
spelling	iium-59542012-02-21T04:36:54Z http://irep.iium.edu.my/5954/ Comparative study between hard bovine gelatin capsule and vegetarian capsule Mohamed, Farahidah Paimin, Hafizurrahman Awang, Mohamed Abdullah Hazim, Anas RS Pharmacy and materia medica INTRODUCTION: Objective of this study is to compare in-vitro performance of hard bovine gelatin capsule (BC) and hard vegetarian capsules (VC). Such study is timely for several reasons: 1) to find alternative for animal-origin capsule especially when the issue like Bovine Sponge Encephalitis (BSE) arise; 2) to establish scientific data with regard to comparable performance of VC as compared to BC. The model drug that was used was mefenamic acid as it is one of the most widely used Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). MATERIALS AND METHOD: The drug and relevant excipients were encapsulated into the two types of capsule using manually-operated capsule filling machine. Several variables including different ratio of disintegrant (corn starch) to filler (lactose alpha-monohydrate) were tested as a function of disintegration test. The capsules were stored in a stability chamber with a controlled condition of 40°c and relative humidity of 65. At pre-determined time (weekly interval) 6 capsules at a time were taken for disintegration test at pH 1 to 3. RESULTS AND DISCUSSION: The results showed that regardless of the ratio between disintegrant and filler, and regardless of pH of disintegrant media, the disintegration of the vegetarian capsules were consistent (4-5 min) throughout the study period (1 month) with stable physical appearance. In contrast, disintegration test for hard bovine gelatin capsule increase with time and the shells were becoming hardened and dented at week 4. This finding may suggest that the structure of VC were more stable compared to the BC thus required more time for it to disintegrate. The disintegration rate of the two capsules were also affected by the use of sodium starch glycolate as disintegrant as the capsules disintegrated faster when they were filled with sodium starch glyclate. CONCLUSION: The results demonstrated that the in-vitro performance of vegetarian capsules was not comparable to the hard bovine gelatin capsule. Surprisingly, the VC showed better in-vitro performance in terms of disintegration and stability than the BC which suggests that vegetarian capsule could be a promising alternative dosage form. 2011 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/5954/2/Comparative_Study_between_Hard_Bovine_Gelatin__poster_farahidah_final.pdf Mohamed, Farahidah and Paimin, Hafizurrahman and Awang, Mohamed and Abdullah Hazim, Anas (2011) Comparative study between hard bovine gelatin capsule and vegetarian capsule. In: International Health Conference IIUM 2011, 7-8 December 2011, Hotel Vistana, Kuantan, Pahang, Malaysia. http://www.iium.edu.my/ihsci2011/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Mohamed, Farahidah Paimin, Hafizurrahman Awang, Mohamed Abdullah Hazim, Anas Comparative study between hard bovine gelatin capsule and vegetarian capsule
description	INTRODUCTION: Objective of this study is to compare in-vitro performance of hard bovine gelatin capsule (BC) and hard vegetarian capsules (VC). Such study is timely for several reasons: 1) to find alternative for animal-origin capsule especially when the issue like Bovine Sponge Encephalitis (BSE) arise; 2) to establish scientific data with regard to comparable performance of VC as compared to BC. The model drug that was used was mefenamic acid as it is one of the most widely used Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). MATERIALS AND METHOD: The drug and relevant excipients were encapsulated into the two types of capsule using manually-operated capsule filling machine. Several variables including different ratio of disintegrant (corn starch) to filler (lactose alpha-monohydrate) were tested as a function of disintegration test. The capsules were stored in a stability chamber with a controlled condition of 40°c and relative humidity of 65. At pre-determined time (weekly interval) 6 capsules at a time were taken for disintegration test at pH 1 to 3. RESULTS AND DISCUSSION: The results showed that regardless of the ratio between disintegrant and filler, and regardless of pH of disintegrant media, the disintegration of the vegetarian capsules were consistent (4-5 min) throughout the study period (1 month) with stable physical appearance. In contrast, disintegration test for hard bovine gelatin capsule increase with time and the shells were becoming hardened and dented at week 4. This finding may suggest that the structure of VC were more stable compared to the BC thus required more time for it to disintegrate. The disintegration rate of the two capsules were also affected by the use of sodium starch glycolate as disintegrant as the capsules disintegrated faster when they were filled with sodium starch glyclate. CONCLUSION: The results demonstrated that the in-vitro performance of vegetarian capsules was not comparable to the hard bovine gelatin capsule. Surprisingly, the VC showed better in-vitro performance in terms of disintegration and stability than the BC which suggests that vegetarian capsule could be a promising alternative dosage form.
format	Conference or Workshop Item
author	Mohamed, Farahidah Paimin, Hafizurrahman Awang, Mohamed Abdullah Hazim, Anas
author_facet	Mohamed, Farahidah Paimin, Hafizurrahman Awang, Mohamed Abdullah Hazim, Anas
author_sort	Mohamed, Farahidah
title	Comparative study between hard bovine gelatin capsule and vegetarian capsule
title_short	Comparative study between hard bovine gelatin capsule and vegetarian capsule
title_full	Comparative study between hard bovine gelatin capsule and vegetarian capsule
title_fullStr	Comparative study between hard bovine gelatin capsule and vegetarian capsule
title_full_unstemmed	Comparative study between hard bovine gelatin capsule and vegetarian capsule
title_sort	comparative study between hard bovine gelatin capsule and vegetarian capsule
publishDate	2011
url	http://irep.iium.edu.my/5954/ http://irep.iium.edu.my/5954/ http://irep.iium.edu.my/5954/2/Comparative_Study_between_Hard_Bovine_Gelatin__poster_farahidah_final.pdf
first_indexed	2023-09-18T20:14:46Z
last_indexed	2023-09-18T20:14:46Z
_version_	1777407714232631296

Comparative study between hard bovine gelatin capsule and vegetarian capsule

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