Early outcomes from a randomized, controlled trial of supervised exercise, angioplasty, and combined therapy in intermittent claudication

BACKGROUND: To compare angioplasty (PTA), supervised exercise (SEP) and PTA + SEP in the treatment of intermittent claudication (IC) due to femoropopliteal disease. METHODS: Over a 6-year period, 178 patients (108 men; median age, 70 years) with femoropopliteal lesions suitable for angioplasty we...

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Main Authors:	Mazari, Fayyaz Ali Khan, Gulati, Sumit M., Abdul Rahman, Mohd Norhisham Azmi, Lee, H L, Mehta, Tapan Anil, McCollum, Peter Thomas, Chetter, Ian Clifford
Format:	Article
Language:	English
Published:	Elsevier 2010
Subjects:	RD Surgery
Online Access:	http://irep.iium.edu.my/59245/ http://irep.iium.edu.my/59245/ http://irep.iium.edu.my/59245/ http://irep.iium.edu.my/59245/1/Early%20outcomes%20from%20a%20randomized%2C%20controlled%20trial%20of%20supervised%20exercise%2C%20angioplasty%2C%20and%20combined%20therapy%20in%20intermittent%20claudication.pdf

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spelling	iium-592452017-11-10T02:21:28Z http://irep.iium.edu.my/59245/ Early outcomes from a randomized, controlled trial of supervised exercise, angioplasty, and combined therapy in intermittent claudication Mazari, Fayyaz Ali Khan Gulati, Sumit M. Abdul Rahman, Mohd Norhisham Azmi Lee, H L Mehta, Tapan Anil McCollum, Peter Thomas Chetter, Ian Clifford RD Surgery BACKGROUND: To compare angioplasty (PTA), supervised exercise (SEP) and PTA + SEP in the treatment of intermittent claudication (IC) due to femoropopliteal disease. METHODS: Over a 6-year period, 178 patients (108 men; median age, 70 years) with femoropopliteal lesions suitable for angioplasty were randomized to PTA, SEP, or PTA + SEP. Patients were assessed prior to and at 1 and 3 months post treatment. ISCVS outcome criteria (ankle pressures, treadmill walking distances) and quality of life (QoL) questionnaires (SF-36 and VascuQoL) were analyzed. RESULTS: All groups were well matched at baseline. Twenty-one patients withdrew. Results are as follows: Intragroup analysis: All groups demonstrated significant clinical and QoL improvements (Friedman test, p < 0.05). SEP (60 patients, 8 withdrew)-62.7% of patients (n = 32) improved following treatment [20 mild, 9 moderate, 3 marked], 27.4% (n = 14) demonstrated no improvement, and 9.8% (n = 5) deteriorated. PTA (60 patients, 3 withdrew)-66.6% patients (n = 38) improved following treatment [19 mild, 10 moderate, 9 marked], 22.8% (n = 13) demonstrated no improvement, and 10.5% (n = 6) deteriorated. PTA + SEP (58 patients, 10 withdrew)-81.6% of patients (n = 40) improved following treatment [10 mild, 17 moderate, 3 marked], 14.2% (n = 7) demonstrated no improvement, and 4.0% (n = 2) deteriorated. Intergroup analysis: PTA + SEP produce a much greater improvement in clinical outcome measures than PTA or SEP alone, but there was no significant QoL advantage (Kruskal-Wallis test, p > 0.05). CONCLUSION: SEP should be the primary treatment for the patients with claudication and PTA should be supplemented by an SEP. Elsevier 2010-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/59245/1/Early%20outcomes%20from%20a%20randomized%2C%20controlled%20trial%20of%20supervised%20exercise%2C%20angioplasty%2C%20and%20combined%20therapy%20in%20intermittent%20claudication.pdf Mazari, Fayyaz Ali Khan and Gulati, Sumit M. and Abdul Rahman, Mohd Norhisham Azmi and Lee, H L and Mehta, Tapan Anil and McCollum, Peter Thomas and Chetter, Ian Clifford (2010) Early outcomes from a randomized, controlled trial of supervised exercise, angioplasty, and combined therapy in intermittent claudication. Annals of Vascular Surgery, 24 (1). pp. 69-79. ISSN 0890-5096 E-ISSN 1615-5947 http://www.annalsofvascularsurgery.com/article/S0890-5096(09)00167-8/abstract 10.1016/j.avsg.2009.07.005
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RD Surgery
spellingShingle	RD Surgery Mazari, Fayyaz Ali Khan Gulati, Sumit M. Abdul Rahman, Mohd Norhisham Azmi Lee, H L Mehta, Tapan Anil McCollum, Peter Thomas Chetter, Ian Clifford Early outcomes from a randomized, controlled trial of supervised exercise, angioplasty, and combined therapy in intermittent claudication
description	BACKGROUND: To compare angioplasty (PTA), supervised exercise (SEP) and PTA + SEP in the treatment of intermittent claudication (IC) due to femoropopliteal disease. METHODS: Over a 6-year period, 178 patients (108 men; median age, 70 years) with femoropopliteal lesions suitable for angioplasty were randomized to PTA, SEP, or PTA + SEP. Patients were assessed prior to and at 1 and 3 months post treatment. ISCVS outcome criteria (ankle pressures, treadmill walking distances) and quality of life (QoL) questionnaires (SF-36 and VascuQoL) were analyzed. RESULTS: All groups were well matched at baseline. Twenty-one patients withdrew. Results are as follows: Intragroup analysis: All groups demonstrated significant clinical and QoL improvements (Friedman test, p < 0.05). SEP (60 patients, 8 withdrew)-62.7% of patients (n = 32) improved following treatment [20 mild, 9 moderate, 3 marked], 27.4% (n = 14) demonstrated no improvement, and 9.8% (n = 5) deteriorated. PTA (60 patients, 3 withdrew)-66.6% patients (n = 38) improved following treatment [19 mild, 10 moderate, 9 marked], 22.8% (n = 13) demonstrated no improvement, and 10.5% (n = 6) deteriorated. PTA + SEP (58 patients, 10 withdrew)-81.6% of patients (n = 40) improved following treatment [10 mild, 17 moderate, 3 marked], 14.2% (n = 7) demonstrated no improvement, and 4.0% (n = 2) deteriorated. Intergroup analysis: PTA + SEP produce a much greater improvement in clinical outcome measures than PTA or SEP alone, but there was no significant QoL advantage (Kruskal-Wallis test, p > 0.05). CONCLUSION: SEP should be the primary treatment for the patients with claudication and PTA should be supplemented by an SEP.
format	Article
author	Mazari, Fayyaz Ali Khan Gulati, Sumit M. Abdul Rahman, Mohd Norhisham Azmi Lee, H L Mehta, Tapan Anil McCollum, Peter Thomas Chetter, Ian Clifford
author_facet	Mazari, Fayyaz Ali Khan Gulati, Sumit M. Abdul Rahman, Mohd Norhisham Azmi Lee, H L Mehta, Tapan Anil McCollum, Peter Thomas Chetter, Ian Clifford
author_sort	Mazari, Fayyaz Ali Khan
title	Early outcomes from a randomized, controlled trial of supervised exercise, angioplasty, and combined therapy in intermittent claudication
title_short	Early outcomes from a randomized, controlled trial of supervised exercise, angioplasty, and combined therapy in intermittent claudication
title_full	Early outcomes from a randomized, controlled trial of supervised exercise, angioplasty, and combined therapy in intermittent claudication
title_fullStr	Early outcomes from a randomized, controlled trial of supervised exercise, angioplasty, and combined therapy in intermittent claudication
title_full_unstemmed	Early outcomes from a randomized, controlled trial of supervised exercise, angioplasty, and combined therapy in intermittent claudication
title_sort	early outcomes from a randomized, controlled trial of supervised exercise, angioplasty, and combined therapy in intermittent claudication
publisher	Elsevier
publishDate	2010
url	http://irep.iium.edu.my/59245/ http://irep.iium.edu.my/59245/ http://irep.iium.edu.my/59245/ http://irep.iium.edu.my/59245/1/Early%20outcomes%20from%20a%20randomized%2C%20controlled%20trial%20of%20supervised%20exercise%2C%20angioplasty%2C%20and%20combined%20therapy%20in%20intermittent%20claudication.pdf
first_indexed	2023-09-18T21:23:54Z
last_indexed	2023-09-18T21:23:54Z
_version_	1777412063503581184

Early outcomes from a randomized, controlled trial of supervised exercise, angioplasty, and combined therapy in intermittent claudication

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