Anti-ulcerogenic and anti-ulcerative colitis (UC) activities of seven amines derivatives

The Novel target compounds (CP-1-7) were synthesized and tested at doses up to 1000mg/kg for their entitled activities. They exerted promising results without any behavioral changes and mortality in mice. Therefore, according to the results obtained in our study, it could be categorized as highly sa...

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Main Authors:	Awaad, Amani Shafeek, Alafeefy, Ahmed Mahmoud, Alasmary, Fatmah A.S., El-Meligy, Reham M., Alqasoumi, Saleh Ibrahim
Format:	Article
Language:	English English
Published:	King Saud University 2017
Subjects:	Q Science (General) QD Chemistry
Online Access:	http://irep.iium.edu.my/59205/ http://irep.iium.edu.my/59205/ http://irep.iium.edu.my/59205/ http://irep.iium.edu.my/59205/13/59205_Anti-ulcerogenic%20and%20anti-ulcerative_article_new.pdf http://irep.iium.edu.my/59205/19/59205_Anti-ulcerogenic%20and%20anti-ulcerative%20colitis%20%28UC%29_scopus.pdf

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spelling	iium-592052018-04-03T05:37:45Z http://irep.iium.edu.my/59205/ Anti-ulcerogenic and anti-ulcerative colitis (UC) activities of seven amines derivatives Awaad, Amani Shafeek Alafeefy, Ahmed Mahmoud Alasmary, Fatmah A.S. El-Meligy, Reham M. Alqasoumi, Saleh Ibrahim Q Science (General) QD Chemistry The Novel target compounds (CP-1-7) were synthesized and tested at doses up to 1000mg/kg for their entitled activities. They exerted promising results without any behavioral changes and mortality in mice. Therefore, according to the results obtained in our study, it could be categorized as highly safe agents for treating UC since substances possessing LD50 higher than 50mg/kg are considered nontoxic. They also possessed a potent anti-ulcerogenic activity with different potentials. The most effective compound was CP-4, it produced 97.7% ulcer protection of control followed by CP-3, which produced 90.3% protection, while the standard drug ranitidine (100mg/kg) produced 49.2% protection. Compound CP-1 showed lowest activity among the current series, it produced 55.5% protection. The target compounds were significantly more effective than the standard in reducing ulcer index. The anti-ulcerative colitis activity was tested using acetic acid induced colitis model. The curative effect of the tested compounds at a dose of 50mg/kg oral administration on rats showed a potent anti-ulcerative colitis activity with different potentials. They induced a significant decrease in ulcer score, ulcer area, ulcer index and weight/length of the colon specimens.The percent protection of control colitis ranged from 66.8% for CP-7 to 22.3% for CP-5; however the percent protection for dexamesathone (0.1. mg/kg) was 59.3%. The effect of the tested compounds CP-7 and CP-3 at dose 50. mg/kg were significantly more effective than dexamesathone (0.1. mg/kg) in reducing all parameters.Liver functions were not affected as there is no effect on the activity of both AST and ALT in animals that received the compounds, so the compounds didn't reveal hepatotoxic manifestation. Although, the results on kidney functions showed that, CP-1 slightly elevated blood urea concentration and CP-3 & CP-4 slightly elevated serum creatinine; no apparent nephrotoxic manifestations were recorded. King Saud University 2017-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/59205/13/59205_Anti-ulcerogenic%20and%20anti-ulcerative_article_new.pdf application/pdf en http://irep.iium.edu.my/59205/19/59205_Anti-ulcerogenic%20and%20anti-ulcerative%20colitis%20%28UC%29_scopus.pdf Awaad, Amani Shafeek and Alafeefy, Ahmed Mahmoud and Alasmary, Fatmah A.S. and El-Meligy, Reham M. and Alqasoumi, Saleh Ibrahim (2017) Anti-ulcerogenic and anti-ulcerative colitis (UC) activities of seven amines derivatives. Saudi Pharmaceutical Journal, 25 (8). pp. 1125-1129. ISSN 1319-0164 https://ac.els-cdn.com/S131901641730141X/1-s2.0-S131901641730141X-main.pdf?_tid=5c5e9496-c4e9-11e7-9096-00000aab0f01&acdnat=1510189402_818d97a145017a558b3113129a08034c 10.1016/j.jsps.2017.07.003
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	Q Science (General) QD Chemistry
spellingShingle	Q Science (General) QD Chemistry Awaad, Amani Shafeek Alafeefy, Ahmed Mahmoud Alasmary, Fatmah A.S. El-Meligy, Reham M. Alqasoumi, Saleh Ibrahim Anti-ulcerogenic and anti-ulcerative colitis (UC) activities of seven amines derivatives
description	The Novel target compounds (CP-1-7) were synthesized and tested at doses up to 1000mg/kg for their entitled activities. They exerted promising results without any behavioral changes and mortality in mice. Therefore, according to the results obtained in our study, it could be categorized as highly safe agents for treating UC since substances possessing LD50 higher than 50mg/kg are considered nontoxic. They also possessed a potent anti-ulcerogenic activity with different potentials. The most effective compound was CP-4, it produced 97.7% ulcer protection of control followed by CP-3, which produced 90.3% protection, while the standard drug ranitidine (100mg/kg) produced 49.2% protection. Compound CP-1 showed lowest activity among the current series, it produced 55.5% protection. The target compounds were significantly more effective than the standard in reducing ulcer index. The anti-ulcerative colitis activity was tested using acetic acid induced colitis model. The curative effect of the tested compounds at a dose of 50mg/kg oral administration on rats showed a potent anti-ulcerative colitis activity with different potentials. They induced a significant decrease in ulcer score, ulcer area, ulcer index and weight/length of the colon specimens.The percent protection of control colitis ranged from 66.8% for CP-7 to 22.3% for CP-5; however the percent protection for dexamesathone (0.1. mg/kg) was 59.3%. The effect of the tested compounds CP-7 and CP-3 at dose 50. mg/kg were significantly more effective than dexamesathone (0.1. mg/kg) in reducing all parameters.Liver functions were not affected as there is no effect on the activity of both AST and ALT in animals that received the compounds, so the compounds didn't reveal hepatotoxic manifestation. Although, the results on kidney functions showed that, CP-1 slightly elevated blood urea concentration and CP-3 & CP-4 slightly elevated serum creatinine; no apparent nephrotoxic manifestations were recorded.
format	Article
author	Awaad, Amani Shafeek Alafeefy, Ahmed Mahmoud Alasmary, Fatmah A.S. El-Meligy, Reham M. Alqasoumi, Saleh Ibrahim
author_facet	Awaad, Amani Shafeek Alafeefy, Ahmed Mahmoud Alasmary, Fatmah A.S. El-Meligy, Reham M. Alqasoumi, Saleh Ibrahim
author_sort	Awaad, Amani Shafeek
title	Anti-ulcerogenic and anti-ulcerative colitis (UC) activities of seven amines derivatives
title_short	Anti-ulcerogenic and anti-ulcerative colitis (UC) activities of seven amines derivatives
title_full	Anti-ulcerogenic and anti-ulcerative colitis (UC) activities of seven amines derivatives
title_fullStr	Anti-ulcerogenic and anti-ulcerative colitis (UC) activities of seven amines derivatives
title_full_unstemmed	Anti-ulcerogenic and anti-ulcerative colitis (UC) activities of seven amines derivatives
title_sort	anti-ulcerogenic and anti-ulcerative colitis (uc) activities of seven amines derivatives
publisher	King Saud University
publishDate	2017
url	http://irep.iium.edu.my/59205/ http://irep.iium.edu.my/59205/ http://irep.iium.edu.my/59205/ http://irep.iium.edu.my/59205/13/59205_Anti-ulcerogenic%20and%20anti-ulcerative_article_new.pdf http://irep.iium.edu.my/59205/19/59205_Anti-ulcerogenic%20and%20anti-ulcerative%20colitis%20%28UC%29_scopus.pdf
first_indexed	2023-09-18T21:23:50Z
last_indexed	2023-09-18T21:23:50Z
_version_	1777412059378483200

Anti-ulcerogenic and anti-ulcerative colitis (UC) activities of seven amines derivatives

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