Discovery of antimalarial drugs from streptomycetes metabolites using a metabolomic approach

Natural products continue to play an important role as a source of biologically active substances for the development of new drug. Streptomyces, Gram-positive bacteria which are widely distributed in nature, are one of the most popular sources of natural antibiotics. Recently, by using a bioassay-...

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Main Authors:	Ahmad, Siti Junaidah, Abdul Rahim, Mohd Badrin Hanizam, Baharum, Syarul Nataqain, Baba, Mohd Shukri, Mohamad Zin, Noraziah
Format:	Article
Language:	English English
Published:	Publisher, Hindawi Publishing Corporation 2017
Subjects:	RC Internal medicine
Online Access:	http://irep.iium.edu.my/59180/ http://irep.iium.edu.my/59180/ http://irep.iium.edu.my/59180/ http://irep.iium.edu.my/59180/1/59180-Discovery%20of%20antimalarial%20drugs%20from%20streptomycetes.pdf http://irep.iium.edu.my/59180/7/59180_Discovery%20of%20antimalarial%20drugs%20from%20streptomycetes%20metabolites_scopus.pdf

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recordtype	eprints
spelling	iium-591802018-04-18T04:10:36Z http://irep.iium.edu.my/59180/ Discovery of antimalarial drugs from streptomycetes metabolites using a metabolomic approach Ahmad, Siti Junaidah Abdul Rahim, Mohd Badrin Hanizam Baharum, Syarul Nataqain Baba, Mohd Shukri Mohamad Zin, Noraziah RC Internal medicine Natural products continue to play an important role as a source of biologically active substances for the development of new drug. Streptomyces, Gram-positive bacteria which are widely distributed in nature, are one of the most popular sources of natural antibiotics. Recently, by using a bioassay-guided fractionation, an antimalarial compound, Gancidin-W, has been discovered from these bacteria. However, this classical method in identifying potentially novel bioactive compounds from the natural products requires considerable effort and is a time-consuming process. Metabolomics is an emerging “omics” technology in systems biology study which integrated in process of discovering drug from natural products. Metabolomics approach in finding novel therapeutics agent for malaria offers dereplication step in screening phase to shorten the process. The highly sensitive instruments, such as Liquid Chromatography-Mass Spectrophotometry (LC-MS), Gas Chromatography-Mass Spectrophotometry (GC-MS), and Nuclear Magnetic Resonance (1 H-NMR) spectroscopy, provide a wide range of information in the identification of potentially bioactive compounds. The current paper reviews concepts of metabolomics and its application in drug discovery of malaria treatment as well as assessing the antimalarial activity from natural products. Metabolomics approach in malaria drug discovery is still new and needs to be initiated, especially for drug research in Malaysia. Publisher, Hindawi Publishing Corporation 2017 Article PeerReviewed application/pdf en http://irep.iium.edu.my/59180/1/59180-Discovery%20of%20antimalarial%20drugs%20from%20streptomycetes.pdf application/pdf en http://irep.iium.edu.my/59180/7/59180_Discovery%20of%20antimalarial%20drugs%20from%20streptomycetes%20metabolites_scopus.pdf Ahmad, Siti Junaidah and Abdul Rahim, Mohd Badrin Hanizam and Baharum, Syarul Nataqain and Baba, Mohd Shukri and Mohamad Zin, Noraziah (2017) Discovery of antimalarial drugs from streptomycetes metabolites using a metabolomic approach. Journal of Tropical Medicine, 2017. pp. 1-7. ISSN 168-79686 E-ISSN 1687-9694 https://www.hindawi.com/journals/jtm/2017/2189814/ 10.1155/2017/2189814
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RC Internal medicine
spellingShingle	RC Internal medicine Ahmad, Siti Junaidah Abdul Rahim, Mohd Badrin Hanizam Baharum, Syarul Nataqain Baba, Mohd Shukri Mohamad Zin, Noraziah Discovery of antimalarial drugs from streptomycetes metabolites using a metabolomic approach
description	Natural products continue to play an important role as a source of biologically active substances for the development of new drug. Streptomyces, Gram-positive bacteria which are widely distributed in nature, are one of the most popular sources of natural antibiotics. Recently, by using a bioassay-guided fractionation, an antimalarial compound, Gancidin-W, has been discovered from these bacteria. However, this classical method in identifying potentially novel bioactive compounds from the natural products requires considerable effort and is a time-consuming process. Metabolomics is an emerging “omics” technology in systems biology study which integrated in process of discovering drug from natural products. Metabolomics approach in finding novel therapeutics agent for malaria offers dereplication step in screening phase to shorten the process. The highly sensitive instruments, such as Liquid Chromatography-Mass Spectrophotometry (LC-MS), Gas Chromatography-Mass Spectrophotometry (GC-MS), and Nuclear Magnetic Resonance (1 H-NMR) spectroscopy, provide a wide range of information in the identification of potentially bioactive compounds. The current paper reviews concepts of metabolomics and its application in drug discovery of malaria treatment as well as assessing the antimalarial activity from natural products. Metabolomics approach in malaria drug discovery is still new and needs to be initiated, especially for drug research in Malaysia.
format	Article
author	Ahmad, Siti Junaidah Abdul Rahim, Mohd Badrin Hanizam Baharum, Syarul Nataqain Baba, Mohd Shukri Mohamad Zin, Noraziah
author_facet	Ahmad, Siti Junaidah Abdul Rahim, Mohd Badrin Hanizam Baharum, Syarul Nataqain Baba, Mohd Shukri Mohamad Zin, Noraziah
author_sort	Ahmad, Siti Junaidah
title	Discovery of antimalarial drugs from streptomycetes metabolites using a metabolomic approach
title_short	Discovery of antimalarial drugs from streptomycetes metabolites using a metabolomic approach
title_full	Discovery of antimalarial drugs from streptomycetes metabolites using a metabolomic approach
title_fullStr	Discovery of antimalarial drugs from streptomycetes metabolites using a metabolomic approach
title_full_unstemmed	Discovery of antimalarial drugs from streptomycetes metabolites using a metabolomic approach
title_sort	discovery of antimalarial drugs from streptomycetes metabolites using a metabolomic approach
publisher	Publisher, Hindawi Publishing Corporation
publishDate	2017
url	http://irep.iium.edu.my/59180/ http://irep.iium.edu.my/59180/ http://irep.iium.edu.my/59180/ http://irep.iium.edu.my/59180/1/59180-Discovery%20of%20antimalarial%20drugs%20from%20streptomycetes.pdf http://irep.iium.edu.my/59180/7/59180_Discovery%20of%20antimalarial%20drugs%20from%20streptomycetes%20metabolites_scopus.pdf
first_indexed	2023-09-18T21:23:48Z
last_indexed	2023-09-18T21:23:48Z
_version_	1777412056750751744

Discovery of antimalarial drugs from streptomycetes metabolites using a metabolomic approach

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