Discovery of antimalarial drugs from streptomycetes metabolites using a metabolomic approach
Natural products continue to play an important role as a source of biologically active substances for the development of new drug. Streptomyces, Gram-positive bacteria which are widely distributed in nature, are one of the most popular sources of natural antibiotics. Recently, by using a bioassay-...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English English |
| Published: |
Publisher, Hindawi Publishing Corporation
2017
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/59180/ http://irep.iium.edu.my/59180/ http://irep.iium.edu.my/59180/ http://irep.iium.edu.my/59180/1/59180-Discovery%20of%20antimalarial%20drugs%20from%20streptomycetes.pdf http://irep.iium.edu.my/59180/7/59180_Discovery%20of%20antimalarial%20drugs%20from%20streptomycetes%20metabolites_scopus.pdf |
| Summary: | Natural products continue to play an important role as a source of biologically active substances for the development of new
drug. Streptomyces, Gram-positive bacteria which are widely distributed in nature, are one of the most popular sources of natural
antibiotics. Recently, by using a bioassay-guided fractionation, an antimalarial compound, Gancidin-W, has been discovered from
these bacteria. However, this classical method in identifying potentially novel bioactive compounds from the natural products
requires considerable effort and is a time-consuming process. Metabolomics is an emerging “omics” technology in systems biology
study which integrated in process of discovering drug from natural products. Metabolomics approach in finding novel therapeutics
agent for malaria offers dereplication step in screening phase to shorten the process. The highly sensitive instruments, such
as Liquid Chromatography-Mass Spectrophotometry (LC-MS), Gas Chromatography-Mass Spectrophotometry (GC-MS), and
Nuclear Magnetic Resonance (1
H-NMR) spectroscopy, provide a wide range of information in the identification of potentially
bioactive compounds. The current paper reviews concepts of metabolomics and its application in drug discovery of malaria
treatment as well as assessing the antimalarial activity from natural products. Metabolomics approach in malaria drug discovery is
still new and needs to be initiated, especially for drug research in Malaysia. |
|---|