Incremental research approach to describing the pharmacokinetics of ciprofloxacin during extracorporeal membrane oxygenation

Background: Significant interactions between drugs, extracorporeal membrane oxygenation (ECMO) circuits and critical illness may affect the pharmacokinetic properties of antibiotics in critically ill patients receiving ECMO. Objective: To describe the pharmacokinetic properties of ciprofloxacin...

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Main Authors:	Sinnah, Fabrice, Shekar, Kiran, Abdul Aziz, Mohd. Hafiz, Buscher, Hergen, Diab, Sara, Fisquet, Stephanie, Fung, Yoke, McDonald, Charles, Reynolds, Claire, Rudham, Sam, Wallis, Steven C., Welch, Susan, Xie, Jiao, Fraser, John, Roberts, Jason A.
Format:	Article
Language:	English English
Published:	College of Intensive Care Medicine (CICM) 2017
Subjects:	RC82 Medical Emergencies, Critical Care, Intensive Care, First Aid RM Therapeutics. Pharmacology RM300 Drugs and their action RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/59172/ http://irep.iium.edu.my/59172/ http://irep.iium.edu.my/59172/1/CCR_Sinnah_OctSupp17_1pp_auth_prf.pdf http://irep.iium.edu.my/59172/7/59172_Incremental%20research%20approach%20to%20describing%20the%20pharmacokinetics_scopus.pdf

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recordtype	eprints
spelling	iium-591722018-01-28T03:18:19Z http://irep.iium.edu.my/59172/ Incremental research approach to describing the pharmacokinetics of ciprofloxacin during extracorporeal membrane oxygenation Sinnah, Fabrice Shekar, Kiran Abdul Aziz, Mohd. Hafiz Buscher, Hergen Diab, Sara Fisquet, Stephanie Fung, Yoke McDonald, Charles Reynolds, Claire Rudham, Sam Wallis, Steven C. Welch, Susan Xie, Jiao Fraser, John Roberts, Jason A. RC82 Medical Emergencies, Critical Care, Intensive Care, First Aid RM Therapeutics. Pharmacology RM300 Drugs and their action RS Pharmacy and materia medica Background: Significant interactions between drugs, extracorporeal membrane oxygenation (ECMO) circuits and critical illness may affect the pharmacokinetic properties of antibiotics in critically ill patients receiving ECMO. Objective: To describe the pharmacokinetic properties of ciprofloxacin during ECMO by integrating pre-clinical findings (ie, ex vivo and in vivo ovine models) to a critically ill patient. Design, participants and intervention: An ex vivo model of an ECMO circuit was used to describe ciprofloxacin concentration changes over 24 hours. An in vivo ovine model of ECMO was used to describe the population pharmacokinetic properties of ciprofloxacin in three different groups of sheep, and to investigate sources of pharmacokinetic variability. In the final phase, data from a 39-year-old critically ill man was used to validate the findings from the ovine pharmacokinetic model. Results: In the ex vivo model of ECMO circuits, the median concentrations of ciprofloxacin at baseline and at 24 hours after ciprofloxacin infusion were similar. The time course of ciprofloxacin in the in vivo ovine on ECMO model was adequately described by a two-compartment model. The final population primary parameter mean estimates were: clearance (CL), 0.21 L/kg/h (SD, 0.09 L/kg/h) and volume of distribution (Vd ), 0.84 L/kg (SD, 0.12 L/kg). In the critically ill ECMO patient, the primary pharmacokinetic parameter estimates were: CL, 0.15 L/kg/h and Vd , 0.99 L/kg. Conclusions: We provide preliminary evidence that ciprofloxacin dosing in ECMO patients should remain in line with the recommended dosing strategies for critically ill patients not receiving ECMO. College of Intensive Care Medicine (CICM) 2017-10-19 Article PeerReviewed application/pdf en http://irep.iium.edu.my/59172/1/CCR_Sinnah_OctSupp17_1pp_auth_prf.pdf application/pdf en http://irep.iium.edu.my/59172/7/59172_Incremental%20research%20approach%20to%20describing%20the%20pharmacokinetics_scopus.pdf Sinnah, Fabrice and Shekar, Kiran and Abdul Aziz, Mohd. Hafiz and Buscher, Hergen and Diab, Sara and Fisquet, Stephanie and Fung, Yoke and McDonald, Charles and Reynolds, Claire and Rudham, Sam and Wallis, Steven C. and Welch, Susan and Xie, Jiao and Fraser, John and Roberts, Jason A. (2017) Incremental research approach to describing the pharmacokinetics of ciprofloxacin during extracorporeal membrane oxygenation. Critical Care and Resuscitation, 19 (Suppl 1). pp. 8-14. ISSN 1441-2772 https://www.cicm.org.au/Resources/Publications/Journal/2010-2020
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RC82 Medical Emergencies, Critical Care, Intensive Care, First Aid RM Therapeutics. Pharmacology RM300 Drugs and their action RS Pharmacy and materia medica
spellingShingle	RC82 Medical Emergencies, Critical Care, Intensive Care, First Aid RM Therapeutics. Pharmacology RM300 Drugs and their action RS Pharmacy and materia medica Sinnah, Fabrice Shekar, Kiran Abdul Aziz, Mohd. Hafiz Buscher, Hergen Diab, Sara Fisquet, Stephanie Fung, Yoke McDonald, Charles Reynolds, Claire Rudham, Sam Wallis, Steven C. Welch, Susan Xie, Jiao Fraser, John Roberts, Jason A. Incremental research approach to describing the pharmacokinetics of ciprofloxacin during extracorporeal membrane oxygenation
description	Background: Significant interactions between drugs, extracorporeal membrane oxygenation (ECMO) circuits and critical illness may affect the pharmacokinetic properties of antibiotics in critically ill patients receiving ECMO. Objective: To describe the pharmacokinetic properties of ciprofloxacin during ECMO by integrating pre-clinical findings (ie, ex vivo and in vivo ovine models) to a critically ill patient. Design, participants and intervention: An ex vivo model of an ECMO circuit was used to describe ciprofloxacin concentration changes over 24 hours. An in vivo ovine model of ECMO was used to describe the population pharmacokinetic properties of ciprofloxacin in three different groups of sheep, and to investigate sources of pharmacokinetic variability. In the final phase, data from a 39-year-old critically ill man was used to validate the findings from the ovine pharmacokinetic model. Results: In the ex vivo model of ECMO circuits, the median concentrations of ciprofloxacin at baseline and at 24 hours after ciprofloxacin infusion were similar. The time course of ciprofloxacin in the in vivo ovine on ECMO model was adequately described by a two-compartment model. The final population primary parameter mean estimates were: clearance (CL), 0.21 L/kg/h (SD, 0.09 L/kg/h) and volume of distribution (Vd ), 0.84 L/kg (SD, 0.12 L/kg). In the critically ill ECMO patient, the primary pharmacokinetic parameter estimates were: CL, 0.15 L/kg/h and Vd , 0.99 L/kg. Conclusions: We provide preliminary evidence that ciprofloxacin dosing in ECMO patients should remain in line with the recommended dosing strategies for critically ill patients not receiving ECMO.
format	Article
author	Sinnah, Fabrice Shekar, Kiran Abdul Aziz, Mohd. Hafiz Buscher, Hergen Diab, Sara Fisquet, Stephanie Fung, Yoke McDonald, Charles Reynolds, Claire Rudham, Sam Wallis, Steven C. Welch, Susan Xie, Jiao Fraser, John Roberts, Jason A.
author_facet	Sinnah, Fabrice Shekar, Kiran Abdul Aziz, Mohd. Hafiz Buscher, Hergen Diab, Sara Fisquet, Stephanie Fung, Yoke McDonald, Charles Reynolds, Claire Rudham, Sam Wallis, Steven C. Welch, Susan Xie, Jiao Fraser, John Roberts, Jason A.
author_sort	Sinnah, Fabrice
title	Incremental research approach to describing the pharmacokinetics of ciprofloxacin during extracorporeal membrane oxygenation
title_short	Incremental research approach to describing the pharmacokinetics of ciprofloxacin during extracorporeal membrane oxygenation
title_full	Incremental research approach to describing the pharmacokinetics of ciprofloxacin during extracorporeal membrane oxygenation
title_fullStr	Incremental research approach to describing the pharmacokinetics of ciprofloxacin during extracorporeal membrane oxygenation
title_full_unstemmed	Incremental research approach to describing the pharmacokinetics of ciprofloxacin during extracorporeal membrane oxygenation
title_sort	incremental research approach to describing the pharmacokinetics of ciprofloxacin during extracorporeal membrane oxygenation
publisher	College of Intensive Care Medicine (CICM)
publishDate	2017
url	http://irep.iium.edu.my/59172/ http://irep.iium.edu.my/59172/ http://irep.iium.edu.my/59172/1/CCR_Sinnah_OctSupp17_1pp_auth_prf.pdf http://irep.iium.edu.my/59172/7/59172_Incremental%20research%20approach%20to%20describing%20the%20pharmacokinetics_scopus.pdf
first_indexed	2023-09-18T21:23:47Z
last_indexed	2023-09-18T21:23:47Z
_version_	1777412055580540928

Incremental research approach to describing the pharmacokinetics of ciprofloxacin during extracorporeal membrane oxygenation

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