Intraluminal Thrombus has a selective Influence on Matrix Metalloproteinases and Their inhibitors (tissue inhibitors of Matrix Metalloproteinases) in the wall of Abdominal Aortic Aneurysms

Intraluminal Thrombus has a selective Influence on Matrix Metalloproteinases and Their inhibitors (tissue inhibitors of Matrix Metalloproteinases) in the wall of Abdominal Aortic Aneurysms

Background: The influence of intraluminal thrombus (ILT) on the proteolytic environment within the wall of an abdominal aortic aneurysm (AAA) is unknown. This is the first study to examine the correlation between ILT thickness and the levels of matrix metalloproteinases (MMPs) and their natural inhi...

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Main Authors: Khan, J. A., Abdul Rahman, Mohd Norhisham Azmi, Mazari, F. A. K., Shahin, Y, Smith, G, Madden, L, Fagan, M. J., Greenman, J, McCollum, P. T., Chetter, I. C.
Format: Article
Language:English
Published: Elsevier 2012
Subjects:
RD Surgery
Online Access:http://irep.iium.edu.my/59158/
http://irep.iium.edu.my/59158/
http://irep.iium.edu.my/59158/
http://irep.iium.edu.my/59158/1/Intraluminal%20thrombus%20has%20a%20selective%20influence%20on%20matrix%20metalloproteinases%20and%20their%20inhibitors%20%28tissue%20inhibitors%20of%20matrix%20metalloproteinases%29%20in%20the%20wall%20of%20abdomin.pdf
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spelling iium-591582018-01-12T00:59:27Z http://irep.iium.edu.my/59158/ Intraluminal Thrombus has a selective Influence on Matrix Metalloproteinases and Their inhibitors (tissue inhibitors of Matrix Metalloproteinases) in the wall of Abdominal Aortic Aneurysms Khan, J. A. Abdul Rahman, Mohd Norhisham Azmi Mazari, F. A. K. Shahin, Y Smith, G Madden, L Fagan, M. J. Greenman, J McCollum, P. T. Chetter, I. C. RD Surgery Background: The influence of intraluminal thrombus (ILT) on the proteolytic environment within the wall of an abdominal aortic aneurysm (AAA) is unknown. This is the first study to examine the correlation between ILT thickness and the levels of matrix metalloproteinases (MMPs) and their natural inhibitors (tissue inhibitors of matrix metalloproteinases [TIMPs]) within the adjacent AAA wall. Methods: Thirty-five patients undergoing elective repair of AAAs were studied. A single full thickness infrarenal aortic sample was obtained uniformly from the arteriotomy site from each patient. All samples were snap frozen and analyzed for total and active MMP 2, 8, and 9 and TIMP 1 and 2. Thrombus thickness at the specimen site was measured on the preoperative contrast computed tomographic angiograms. Results: There was a statistically significant correlation between ILT thickness, concentration of TIMP 1, and active concentration of MMP 9. MMP 2 (active and total) and TIMP 2 demonstrated a positive correlation with ILT thickness, although not statistically significant. Conclusion: In this novel study, we found a significant positive correlation of ILT thickness with active MMP 9 and TIMP 1 concentration in the adjacent AAA wall, and this may have implications for AAA expansion and eventual rupture. Elsevier 2012-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/59158/1/Intraluminal%20thrombus%20has%20a%20selective%20influence%20on%20matrix%20metalloproteinases%20and%20their%20inhibitors%20%28tissue%20inhibitors%20of%20matrix%20metalloproteinases%29%20in%20the%20wall%20of%20abdomin.pdf Khan, J. A. and Abdul Rahman, Mohd Norhisham Azmi and Mazari, F. A. K. and Shahin, Y and Smith, G and Madden, L and Fagan, M. J. and Greenman, J and McCollum, P. T. and Chetter, I. C. (2012) Intraluminal Thrombus has a selective Influence on Matrix Metalloproteinases and Their inhibitors (tissue inhibitors of Matrix Metalloproteinases) in the wall of Abdominal Aortic Aneurysms. Annals of Vascular Surgery, 26 (3). pp. 322-329. ISSN 0890-5096 E-ISSN 1615-5947 http://www.annalsofvascularsurgery.com/ 10.1016/j.avsg.2011.08.015
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic RD Surgery
spellingShingle RD Surgery
Khan, J. A.
Abdul Rahman, Mohd Norhisham Azmi
Mazari, F. A. K.
Shahin, Y
Smith, G
Madden, L
Fagan, M. J.
Greenman, J
McCollum, P. T.
Chetter, I. C.
Intraluminal Thrombus has a selective Influence on Matrix Metalloproteinases and Their inhibitors (tissue inhibitors of Matrix Metalloproteinases) in the wall of Abdominal Aortic Aneurysms
description Background: The influence of intraluminal thrombus (ILT) on the proteolytic environment within the wall of an abdominal aortic aneurysm (AAA) is unknown. This is the first study to examine the correlation between ILT thickness and the levels of matrix metalloproteinases (MMPs) and their natural inhibitors (tissue inhibitors of matrix metalloproteinases [TIMPs]) within the adjacent AAA wall. Methods: Thirty-five patients undergoing elective repair of AAAs were studied. A single full thickness infrarenal aortic sample was obtained uniformly from the arteriotomy site from each patient. All samples were snap frozen and analyzed for total and active MMP 2, 8, and 9 and TIMP 1 and 2. Thrombus thickness at the specimen site was measured on the preoperative contrast computed tomographic angiograms. Results: There was a statistically significant correlation between ILT thickness, concentration of TIMP 1, and active concentration of MMP 9. MMP 2 (active and total) and TIMP 2 demonstrated a positive correlation with ILT thickness, although not statistically significant. Conclusion: In this novel study, we found a significant positive correlation of ILT thickness with active MMP 9 and TIMP 1 concentration in the adjacent AAA wall, and this may have implications for AAA expansion and eventual rupture.
format Article
author Khan, J. A.
Abdul Rahman, Mohd Norhisham Azmi
Mazari, F. A. K.
Shahin, Y
Smith, G
Madden, L
Fagan, M. J.
Greenman, J
McCollum, P. T.
Chetter, I. C.
author_facet Khan, J. A.
Abdul Rahman, Mohd Norhisham Azmi
Mazari, F. A. K.
Shahin, Y
Smith, G
Madden, L
Fagan, M. J.
Greenman, J
McCollum, P. T.
Chetter, I. C.
author_sort Khan, J. A.
title Intraluminal Thrombus has a selective Influence on Matrix Metalloproteinases and Their inhibitors (tissue inhibitors of Matrix Metalloproteinases) in the wall of Abdominal Aortic Aneurysms
title_short Intraluminal Thrombus has a selective Influence on Matrix Metalloproteinases and Their inhibitors (tissue inhibitors of Matrix Metalloproteinases) in the wall of Abdominal Aortic Aneurysms
title_full Intraluminal Thrombus has a selective Influence on Matrix Metalloproteinases and Their inhibitors (tissue inhibitors of Matrix Metalloproteinases) in the wall of Abdominal Aortic Aneurysms
title_fullStr Intraluminal Thrombus has a selective Influence on Matrix Metalloproteinases and Their inhibitors (tissue inhibitors of Matrix Metalloproteinases) in the wall of Abdominal Aortic Aneurysms
title_full_unstemmed Intraluminal Thrombus has a selective Influence on Matrix Metalloproteinases and Their inhibitors (tissue inhibitors of Matrix Metalloproteinases) in the wall of Abdominal Aortic Aneurysms
title_sort intraluminal thrombus has a selective influence on matrix metalloproteinases and their inhibitors (tissue inhibitors of matrix metalloproteinases) in the wall of abdominal aortic aneurysms
publisher Elsevier
publishDate 2012
url http://irep.iium.edu.my/59158/
http://irep.iium.edu.my/59158/
http://irep.iium.edu.my/59158/
http://irep.iium.edu.my/59158/1/Intraluminal%20thrombus%20has%20a%20selective%20influence%20on%20matrix%20metalloproteinases%20and%20their%20inhibitors%20%28tissue%20inhibitors%20of%20matrix%20metalloproteinases%29%20in%20the%20wall%20of%20abdomin.pdf
first_indexed 2023-09-18T21:23:46Z
last_indexed 2023-09-18T21:23:46Z
_version_ 1777412054548742144

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