Enzyme inhibitory and antioxidant investigations of Tetracera macrophylla Vall. and Entada spiralis Ridl. and isolation of active principles

Diabetes is a serious global health problem that affects over 422 million citizens (WHO, 2014). It is characterized by hyperglycemia, (abnormal increase in plasma glucose level) resulting from hydrolysis of starch by pancreatic α- amylase and glucose uptake by intestinal α- glycosidase. Inhibitors o...

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Main Authors:	Opeyemi Roheem, Fatimah, Ahmed, Qamar Uddin, Mat So'ad, Siti Zaiton
Format:	Conference or Workshop Item
Language:	English English English
Published:	2017
Subjects:	RS403 Materia Medica-Pharmaceutical Chemistry
Online Access:	http://irep.iium.edu.my/59155/ http://irep.iium.edu.my/59155/17/KOP%20symposium_FATIMAH-poster.pdf http://irep.iium.edu.my/59155/29/KOP%20symposium%202017.pdf http://irep.iium.edu.my/59155/23/Mail%20-%2059155.pdf

id	iium-59155
recordtype	eprints
spelling	iium-591552018-12-18T07:43:23Z http://irep.iium.edu.my/59155/ Enzyme inhibitory and antioxidant investigations of Tetracera macrophylla Vall. and Entada spiralis Ridl. and isolation of active principles Opeyemi Roheem, Fatimah Ahmed, Qamar Uddin Mat So'ad, Siti Zaiton RS403 Materia Medica-Pharmaceutical Chemistry Diabetes is a serious global health problem that affects over 422 million citizens (WHO, 2014). It is characterized by hyperglycemia, (abnormal increase in plasma glucose level) resulting from hydrolysis of starch by pancreatic α- amylase and glucose uptake by intestinal α- glycosidase. Inhibitors of these two enzymes have been suggested to be better candidates in preventing diabetes and its complications. Pancreatic α- amylase is an enzyme that helps in the hydrolysis of starch into maltose prior to absorption.α- glucosidase enzyme catalyses the breakage of disaccharide to glucose, inhibiting these enzymes retards the dietary carbohydrate uptake and supress the postprandial hyperglycemia. Therefore, the most effective strategy of controlling diabetes is to inhibit the actions of these enzymes (Apostollidis & Lee, 2010; Striegel et al., 2015. Additionally Free radicals are considered as a major causative factor of cell damage that degenerate into chronic diseases such type 2 DM, liver problem, stroke and cancers. From ancient times antioxidants from herbal extracts and drinks were utilized and many have been proved to improve antioxidant capacity and therefore prevent cell and tissue damage. Tetracera macrophylla Vall (family: Dilliniacea) is an evergreen climber that widely spreads across Sumatra, Peninsula Malaysia, Bangka and Borneo and some parts of Africa. . It plays an important role in traditional herbal medicine for curing many ailments. Similarly, Entada spiralis Ridl (Family : leguminosae) locally known as Beluru or Sintok is a woody climber that can grow up to 25 m tall, possessing a wide range of ethno medicinal uses. Many species of Entada and Tetracera have been scientifically investigated on several ailments, these plants lacks scientific record to proof their vast medicinal uses, this research therefore aim to investigate the inhibitory capacity of these plants on digestive enzymes and free radicals as many species of the genus have been validated for these activities. 2017-08-08 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/59155/17/KOP%20symposium_FATIMAH-poster.pdf application/pdf en http://irep.iium.edu.my/59155/29/KOP%20symposium%202017.pdf application/pdf en http://irep.iium.edu.my/59155/23/Mail%20-%2059155.pdf Opeyemi Roheem, Fatimah and Ahmed, Qamar Uddin and Mat So'ad, Siti Zaiton (2017) Enzyme inhibitory and antioxidant investigations of Tetracera macrophylla Vall. and Entada spiralis Ridl. and isolation of active principles. In: Kulliyyah of Pharmacy Research Symposium 2017, 7th-8th August 2017, Kuantan, Pahang. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RS403 Materia Medica-Pharmaceutical Chemistry
spellingShingle	RS403 Materia Medica-Pharmaceutical Chemistry Opeyemi Roheem, Fatimah Ahmed, Qamar Uddin Mat So'ad, Siti Zaiton Enzyme inhibitory and antioxidant investigations of Tetracera macrophylla Vall. and Entada spiralis Ridl. and isolation of active principles
description	Diabetes is a serious global health problem that affects over 422 million citizens (WHO, 2014). It is characterized by hyperglycemia, (abnormal increase in plasma glucose level) resulting from hydrolysis of starch by pancreatic α- amylase and glucose uptake by intestinal α- glycosidase. Inhibitors of these two enzymes have been suggested to be better candidates in preventing diabetes and its complications. Pancreatic α- amylase is an enzyme that helps in the hydrolysis of starch into maltose prior to absorption.α- glucosidase enzyme catalyses the breakage of disaccharide to glucose, inhibiting these enzymes retards the dietary carbohydrate uptake and supress the postprandial hyperglycemia. Therefore, the most effective strategy of controlling diabetes is to inhibit the actions of these enzymes (Apostollidis & Lee, 2010; Striegel et al., 2015. Additionally Free radicals are considered as a major causative factor of cell damage that degenerate into chronic diseases such type 2 DM, liver problem, stroke and cancers. From ancient times antioxidants from herbal extracts and drinks were utilized and many have been proved to improve antioxidant capacity and therefore prevent cell and tissue damage. Tetracera macrophylla Vall (family: Dilliniacea) is an evergreen climber that widely spreads across Sumatra, Peninsula Malaysia, Bangka and Borneo and some parts of Africa. . It plays an important role in traditional herbal medicine for curing many ailments. Similarly, Entada spiralis Ridl (Family : leguminosae) locally known as Beluru or Sintok is a woody climber that can grow up to 25 m tall, possessing a wide range of ethno medicinal uses. Many species of Entada and Tetracera have been scientifically investigated on several ailments, these plants lacks scientific record to proof their vast medicinal uses, this research therefore aim to investigate the inhibitory capacity of these plants on digestive enzymes and free radicals as many species of the genus have been validated for these activities.
format	Conference or Workshop Item
author	Opeyemi Roheem, Fatimah Ahmed, Qamar Uddin Mat So'ad, Siti Zaiton
author_facet	Opeyemi Roheem, Fatimah Ahmed, Qamar Uddin Mat So'ad, Siti Zaiton
author_sort	Opeyemi Roheem, Fatimah
title	Enzyme inhibitory and antioxidant investigations of Tetracera macrophylla Vall. and Entada spiralis Ridl. and isolation of active principles
title_short	Enzyme inhibitory and antioxidant investigations of Tetracera macrophylla Vall. and Entada spiralis Ridl. and isolation of active principles
title_full	Enzyme inhibitory and antioxidant investigations of Tetracera macrophylla Vall. and Entada spiralis Ridl. and isolation of active principles
title_fullStr	Enzyme inhibitory and antioxidant investigations of Tetracera macrophylla Vall. and Entada spiralis Ridl. and isolation of active principles
title_full_unstemmed	Enzyme inhibitory and antioxidant investigations of Tetracera macrophylla Vall. and Entada spiralis Ridl. and isolation of active principles
title_sort	enzyme inhibitory and antioxidant investigations of tetracera macrophylla vall. and entada spiralis ridl. and isolation of active principles
publishDate	2017
url	http://irep.iium.edu.my/59155/ http://irep.iium.edu.my/59155/17/KOP%20symposium_FATIMAH-poster.pdf http://irep.iium.edu.my/59155/29/KOP%20symposium%202017.pdf http://irep.iium.edu.my/59155/23/Mail%20-%2059155.pdf
first_indexed	2023-09-18T21:23:45Z
last_indexed	2023-09-18T21:23:45Z
_version_	1777412054239412224

Enzyme inhibitory and antioxidant investigations of Tetracera macrophylla Vall. and Entada spiralis Ridl. and isolation of active principles

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