Early result: randomized controlled trial of treatment for intermittent claudication

Objective: To compare angioplasty (PTA), supervised exercise (SEP) and PTA + SEP in the treatment of intermittent claudication (IC) due to femoro-popliteal disease Methods: Over a 6 years period, 178 patients (108 men, median age 70 years) with angioplastiable femoro-popliteal lesions were rando...

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Main Authors:	Khan, Mazari Fayyaz Ali, Sumit, Gulati, Lee, H. L. D., Tapan, Mehta, Abdul Rahman, Mohd Norhisham Azmi, Ian, Chetter
Format:	Conference or Workshop Item
Language:	English
Published:	Wiley 2008
Subjects:	RD Surgery
Online Access:	http://irep.iium.edu.my/59154/ http://irep.iium.edu.my/59154/ http://irep.iium.edu.my/59154/1/British%20Journal%20of%20Surgery%202008%2C%2095%28S6%29%2C%201%E2%80%93104.pdf

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spelling	iium-591542017-11-07T08:36:39Z http://irep.iium.edu.my/59154/ Early result: randomized controlled trial of treatment for intermittent claudication Khan, Mazari Fayyaz Ali Sumit, Gulati Lee, H. L. D. Tapan, Mehta Abdul Rahman, Mohd Norhisham Azmi Ian, Chetter RD Surgery Objective: To compare angioplasty (PTA), supervised exercise (SEP) and PTA + SEP in the treatment of intermittent claudication (IC) due to femoro-popliteal disease Methods: Over a 6 years period, 178 patients (108 men, median age 70 years) with angioplastiable femoro-popliteal lesions were randomized to: PTA, SEP or PTA + SEP. Patients were assessed prior to and at 1 & 3 month post treatment. ISCVS outcome criteria (Ankle pressures, treadmill walking distances) and Quality of Life (QoL) questionnaires (SF36 and VascuQoL) were analysed. Results: All groups were well matched at baseline. 21 patients withdrew. Intra group analysis: All groups demonstrated significant clinical and QoL improvements (Friedman test, p < 0·05). SEP (59 patients, 8 withdrew) – 62·7% of patients (n = 32) improved following treatment [20 mild, 9 moderate, 3 marked], 27·4% (n = 14) no improvement and 9·8% (n = 5) deteriorated. PTA (60 patients, 3 withdrew) – 66·6% of patients (n = 38) improved following treatment [19mild, 10 moderate, 9 marked], 22·8% (n = 13) no improvement and 10·5% (n = 6) deteriorated. PTA + SEP (59 patients, 10 withdrew) – 81·6% of patients (n = 40) improved following treatment. [10 mild, 17 moderate, 13 marked], 14·2%% (n = 7) no improvement and 4·0% (n = 2) deteriorated Inter group Analysis: PTA + SEP produce a much greater improvement in clinical outcome measures than PTA or SEP alone, but there was no significant Q0L advantage (Kruskal Wallis test, p > 0·05). Conclusion: SEP should be the primary treatment for the patients with claudication and PTA should be supplemented by a SEP. Wiley 2008 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/59154/1/British%20Journal%20of%20Surgery%202008%2C%2095%28S6%29%2C%201%E2%80%93104.pdf Khan, Mazari Fayyaz Ali and Sumit, Gulati and Lee, H. L. D. and Tapan, Mehta and Abdul Rahman, Mohd Norhisham Azmi and Ian, Chetter (2008) Early result: randomized controlled trial of treatment for intermittent claudication. In: 43rd Congress of the European Society for Surgical Research 2008, 21st-24th May 2008, Warsaw, Poland. https://www.bjs.co.uk/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RD Surgery
spellingShingle	RD Surgery Khan, Mazari Fayyaz Ali Sumit, Gulati Lee, H. L. D. Tapan, Mehta Abdul Rahman, Mohd Norhisham Azmi Ian, Chetter Early result: randomized controlled trial of treatment for intermittent claudication
description	Objective: To compare angioplasty (PTA), supervised exercise (SEP) and PTA + SEP in the treatment of intermittent claudication (IC) due to femoro-popliteal disease Methods: Over a 6 years period, 178 patients (108 men, median age 70 years) with angioplastiable femoro-popliteal lesions were randomized to: PTA, SEP or PTA + SEP. Patients were assessed prior to and at 1 & 3 month post treatment. ISCVS outcome criteria (Ankle pressures, treadmill walking distances) and Quality of Life (QoL) questionnaires (SF36 and VascuQoL) were analysed. Results: All groups were well matched at baseline. 21 patients withdrew. Intra group analysis: All groups demonstrated significant clinical and QoL improvements (Friedman test, p < 0·05). SEP (59 patients, 8 withdrew) – 62·7% of patients (n = 32) improved following treatment [20 mild, 9 moderate, 3 marked], 27·4% (n = 14) no improvement and 9·8% (n = 5) deteriorated. PTA (60 patients, 3 withdrew) – 66·6% of patients (n = 38) improved following treatment [19mild, 10 moderate, 9 marked], 22·8% (n = 13) no improvement and 10·5% (n = 6) deteriorated. PTA + SEP (59 patients, 10 withdrew) – 81·6% of patients (n = 40) improved following treatment. [10 mild, 17 moderate, 13 marked], 14·2%% (n = 7) no improvement and 4·0% (n = 2) deteriorated Inter group Analysis: PTA + SEP produce a much greater improvement in clinical outcome measures than PTA or SEP alone, but there was no significant Q0L advantage (Kruskal Wallis test, p > 0·05). Conclusion: SEP should be the primary treatment for the patients with claudication and PTA should be supplemented by a SEP.
format	Conference or Workshop Item
author	Khan, Mazari Fayyaz Ali Sumit, Gulati Lee, H. L. D. Tapan, Mehta Abdul Rahman, Mohd Norhisham Azmi Ian, Chetter
author_facet	Khan, Mazari Fayyaz Ali Sumit, Gulati Lee, H. L. D. Tapan, Mehta Abdul Rahman, Mohd Norhisham Azmi Ian, Chetter
author_sort	Khan, Mazari Fayyaz Ali
title	Early result: randomized controlled trial of treatment for intermittent claudication
title_short	Early result: randomized controlled trial of treatment for intermittent claudication
title_full	Early result: randomized controlled trial of treatment for intermittent claudication
title_fullStr	Early result: randomized controlled trial of treatment for intermittent claudication
title_full_unstemmed	Early result: randomized controlled trial of treatment for intermittent claudication
title_sort	early result: randomized controlled trial of treatment for intermittent claudication
publisher	Wiley
publishDate	2008
url	http://irep.iium.edu.my/59154/ http://irep.iium.edu.my/59154/ http://irep.iium.edu.my/59154/1/British%20Journal%20of%20Surgery%202008%2C%2095%28S6%29%2C%201%E2%80%93104.pdf
first_indexed	2023-09-18T21:23:45Z
last_indexed	2023-09-18T21:23:45Z
_version_	1777412054096805888

Early result: randomized controlled trial of treatment for intermittent claudication

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