Standardization of Malaysia herbs using metabolomics approach

Medicinal herbs have reached extensive acceptability as therapeutic agents for several diseases. However, the use of medicinal herbs is limited due to the issue on quality and safety assurance, as well as lack of scientific proof. Standardization is an important aspect for maintaining and assessing...

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Main Author:	Khatib, Alfi
Format:	Conference or Workshop Item
Language:	English English
Published:	2017
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/59140/ http://irep.iium.edu.my/59140/3/Summary%20for%20the%20Asian%20Oceania%20Metabolomics%20Forum.pdf http://irep.iium.edu.my/59140/4/invitation%20letter.pdf

id	iium-59140
recordtype	eprints
spelling	iium-591402017-11-07T07:08:45Z http://irep.iium.edu.my/59140/ Standardization of Malaysia herbs using metabolomics approach Khatib, Alfi RS Pharmacy and materia medica Medicinal herbs have reached extensive acceptability as therapeutic agents for several diseases. However, the use of medicinal herbs is limited due to the issue on quality and safety assurance, as well as lack of scientific proof. Standardization is an important aspect for maintaining and assessing the quality and safety of medicinal herb. It includes raw plant authentication, microscopic and molecular examination, and identification of chemical composition. The challenge of natural chemists is to identify as much as possible the bioactive compounds and to study their mode of action to treat the diseases. This work is not easy due to the complexity of the compounds and limitation of time and budget. A lead finding with bioassay guided fractionation developing into high throughput screening could not increase the number of potential natural products in the pipeline of the pharmaceutical companies. Therefore, a new approach amends the inclusion of system biology in pharmacognosy research by using metabolomics as a tool. Metabolomics is a comprehensive analysis of the whole metabolites in a sample. Identification of both chemical and bio-markers can be performed by the instrumental analysis of both natural sources and animal bio-fluids and multivariate data analysis. All advanced instrumentation such as nuclear magnetic resonance spectroscopy, liquid chromatography-mass spectrometry, and gas chromatography-mass spectrometry are used in metabolomics. In this presentation, a brief review on our experience to standardize some Malaysian herbs (Orthosiphon stamineus, Centella asiatica, and Clinacanthus nutans) is discussed. 2017-09-06 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/59140/3/Summary%20for%20the%20Asian%20Oceania%20Metabolomics%20Forum.pdf application/pdf en http://irep.iium.edu.my/59140/4/invitation%20letter.pdf Khatib, Alfi (2017) Standardization of Malaysia herbs using metabolomics approach. In: Asian Oceania Metabolomics Forum, 6th-8th September 2017, Bangkok, Thailand. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Khatib, Alfi Standardization of Malaysia herbs using metabolomics approach
description	Medicinal herbs have reached extensive acceptability as therapeutic agents for several diseases. However, the use of medicinal herbs is limited due to the issue on quality and safety assurance, as well as lack of scientific proof. Standardization is an important aspect for maintaining and assessing the quality and safety of medicinal herb. It includes raw plant authentication, microscopic and molecular examination, and identification of chemical composition. The challenge of natural chemists is to identify as much as possible the bioactive compounds and to study their mode of action to treat the diseases. This work is not easy due to the complexity of the compounds and limitation of time and budget. A lead finding with bioassay guided fractionation developing into high throughput screening could not increase the number of potential natural products in the pipeline of the pharmaceutical companies. Therefore, a new approach amends the inclusion of system biology in pharmacognosy research by using metabolomics as a tool. Metabolomics is a comprehensive analysis of the whole metabolites in a sample. Identification of both chemical and bio-markers can be performed by the instrumental analysis of both natural sources and animal bio-fluids and multivariate data analysis. All advanced instrumentation such as nuclear magnetic resonance spectroscopy, liquid chromatography-mass spectrometry, and gas chromatography-mass spectrometry are used in metabolomics. In this presentation, a brief review on our experience to standardize some Malaysian herbs (Orthosiphon stamineus, Centella asiatica, and Clinacanthus nutans) is discussed.
format	Conference or Workshop Item
author	Khatib, Alfi
author_facet	Khatib, Alfi
author_sort	Khatib, Alfi
title	Standardization of Malaysia herbs using metabolomics approach
title_short	Standardization of Malaysia herbs using metabolomics approach
title_full	Standardization of Malaysia herbs using metabolomics approach
title_fullStr	Standardization of Malaysia herbs using metabolomics approach
title_full_unstemmed	Standardization of Malaysia herbs using metabolomics approach
title_sort	standardization of malaysia herbs using metabolomics approach
publishDate	2017
url	http://irep.iium.edu.my/59140/ http://irep.iium.edu.my/59140/3/Summary%20for%20the%20Asian%20Oceania%20Metabolomics%20Forum.pdf http://irep.iium.edu.my/59140/4/invitation%20letter.pdf
first_indexed	2023-09-18T21:23:44Z
last_indexed	2023-09-18T21:23:44Z
_version_	1777412053024112640

Standardization of Malaysia herbs using metabolomics approach

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