Nano-encapsulation of proteins and peptides

The significance of protein and peptide use as therapeutic agents in parallel with conventional drugs has long been established with the use of insulin, growth hormones and antibiotics for treatment of diseases. Proteins and peptides offer high specificity, precise function and low immune response f...

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Main Authors:	Ibrahim Ali, Noorbatcha, Jaswir, Irwandi, Ahmad, Hasna
Format:	Article
Language:	English
Published:	Bentham Science 2017
Subjects:	TP Chemical technology TP248.13 Biotechnology
Online Access:	http://irep.iium.edu.my/59139/ http://irep.iium.edu.my/59139/ http://irep.iium.edu.my/59139/ http://irep.iium.edu.my/59139/1/Noor%20batcha-MS%20proof2.pdf

id	iium-59139
recordtype	eprints
spelling	iium-591392017-11-07T07:38:01Z http://irep.iium.edu.my/59139/ Nano-encapsulation of proteins and peptides Ibrahim Ali, Noorbatcha Jaswir, Irwandi Ahmad, Hasna TP Chemical technology TP248.13 Biotechnology The significance of protein and peptide use as therapeutic agents in parallel with conventional drugs has long been established with the use of insulin, growth hormones and antibiotics for treatment of diseases. Proteins and peptides offer high specificity, precise function and low immune response from the body. These therapeutic molecules are administered via intravenous and subcutaneous injection, oral administration and nasal inhalation. However, their macromolecular size and high susceptibility to degradation in the body when administered hamper their effective delivery and action. Nanoencapsulation of proteins and peptides is an attractive strategy to improve the stability of proteins and peptides and maintain activity at the target site. Encapsulation into nanoparticles ensures that the proteins and peptides are more stable, bioavailable and more effective due to sustained release and targeted delivery; the smaller size equals larger surface area to volume ratio allows for better absorption in the intestinal lumen. However, challenges are still present in formulating nanoparticles with desired physicochemical properties for their effective action and sustained release. The need for case- by case formulation of protein/ peptide, limitations in the available methods for fabrication, characterization and analysis of the nanoparticles, as well as difficulty in translating lab- scale research into commercial stage are the current problems that need to be addressed. Furthermore, it is important to assess that nanoparticle formulations are commercially sustainable next to free form drugs. Many gaps need to be filled in understanding the nature of proteins and peptides, their fabrication into nanoparticles, and successful translation into clinical products. Continued focus into research in these areas is the way forward for the future of protein and peptide delivery. Bentham Science 2017 Article PeerReviewed application/pdf en http://irep.iium.edu.my/59139/1/Noor%20batcha-MS%20proof2.pdf Ibrahim Ali, Noorbatcha and Jaswir, Irwandi and Ahmad, Hasna (2017) Nano-encapsulation of proteins and peptides. Current Nanomaterials. ISSN 2405-4615 E-ISSN 2405-4623 (In Press) http://www.eurekaselect.com/155512 10.2174/2405461502666170912100212
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	TP Chemical technology TP248.13 Biotechnology
spellingShingle	TP Chemical technology TP248.13 Biotechnology Ibrahim Ali, Noorbatcha Jaswir, Irwandi Ahmad, Hasna Nano-encapsulation of proteins and peptides
description	The significance of protein and peptide use as therapeutic agents in parallel with conventional drugs has long been established with the use of insulin, growth hormones and antibiotics for treatment of diseases. Proteins and peptides offer high specificity, precise function and low immune response from the body. These therapeutic molecules are administered via intravenous and subcutaneous injection, oral administration and nasal inhalation. However, their macromolecular size and high susceptibility to degradation in the body when administered hamper their effective delivery and action. Nanoencapsulation of proteins and peptides is an attractive strategy to improve the stability of proteins and peptides and maintain activity at the target site. Encapsulation into nanoparticles ensures that the proteins and peptides are more stable, bioavailable and more effective due to sustained release and targeted delivery; the smaller size equals larger surface area to volume ratio allows for better absorption in the intestinal lumen. However, challenges are still present in formulating nanoparticles with desired physicochemical properties for their effective action and sustained release. The need for case- by case formulation of protein/ peptide, limitations in the available methods for fabrication, characterization and analysis of the nanoparticles, as well as difficulty in translating lab- scale research into commercial stage are the current problems that need to be addressed. Furthermore, it is important to assess that nanoparticle formulations are commercially sustainable next to free form drugs. Many gaps need to be filled in understanding the nature of proteins and peptides, their fabrication into nanoparticles, and successful translation into clinical products. Continued focus into research in these areas is the way forward for the future of protein and peptide delivery.
format	Article
author	Ibrahim Ali, Noorbatcha Jaswir, Irwandi Ahmad, Hasna
author_facet	Ibrahim Ali, Noorbatcha Jaswir, Irwandi Ahmad, Hasna
author_sort	Ibrahim Ali, Noorbatcha
title	Nano-encapsulation of proteins and peptides
title_short	Nano-encapsulation of proteins and peptides
title_full	Nano-encapsulation of proteins and peptides
title_fullStr	Nano-encapsulation of proteins and peptides
title_full_unstemmed	Nano-encapsulation of proteins and peptides
title_sort	nano-encapsulation of proteins and peptides
publisher	Bentham Science
publishDate	2017
url	http://irep.iium.edu.my/59139/ http://irep.iium.edu.my/59139/ http://irep.iium.edu.my/59139/ http://irep.iium.edu.my/59139/1/Noor%20batcha-MS%20proof2.pdf
first_indexed	2023-09-18T21:23:44Z
last_indexed	2023-09-18T21:23:44Z
_version_	1777412052890943488

Nano-encapsulation of proteins and peptides

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