Effect of cooling rates on shape and crystal size distributions of mefenamic acid polymorph in ethyl acetate

This study investigate the effect of cooling rates on mefenamic acid crystallisation in ethyl acetate. The cooling rate was varied from 0.2 to 5 °C/min. The in-line conductivity system and turbidity system were employed to detect the onset of the crystallization process. The crystals produced wer...

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Main Authors:	Abdul Mudalip, S. K., Adam, Fatmawati, Jamal, Parveen, Abu Bakar, Mohd Rushdi, Amran, Nur Amelia, Sulaiman, Siti Zubaidah, Che Man, Rohaida, Mohd Arshad, Z.I., Shaarani, Shalyda Md
Format:	Conference or Workshop Item
Language:	English English English
Published:	IOP Publishing 2017
Subjects:	T Technology (General)
Online Access:	http://irep.iium.edu.my/58987/ http://irep.iium.edu.my/58987/ http://irep.iium.edu.my/58987/ http://irep.iium.edu.my/58987/1/58987-Effect%20of%20Cooling%20Rates%20on%20Shape-SCOPUS.pdf http://irep.iium.edu.my/58987/2/58987-Effect%20of%20Cooling%20Rates%20on%20Shape%20and%20Crystal%20Size.pdf http://irep.iium.edu.my/58987/13/58987%20Effect%20of%20Cooling%20Rates%20on%20Shape%20WOS.pdf

id	iium-58987
recordtype	eprints
spelling	iium-589872019-08-17T08:16:31Z http://irep.iium.edu.my/58987/ Effect of cooling rates on shape and crystal size distributions of mefenamic acid polymorph in ethyl acetate Abdul Mudalip, S. K. Adam, Fatmawati Jamal, Parveen Abu Bakar, Mohd Rushdi Amran, Nur Amelia Sulaiman, Siti Zubaidah Che Man, Rohaida Mohd Arshad, Z.I. Shaarani, Shalyda Md T Technology (General) This study investigate the effect of cooling rates on mefenamic acid crystallisation in ethyl acetate. The cooling rate was varied from 0.2 to 5 °C/min. The in-line conductivity system and turbidity system were employed to detect the onset of the crystallization process. The crystals produced were analysed using optical microscopy and Fourier transform infrared spectroscopy (FTIR). It was found that the crystals produced at different cooling rates were needle-like and exhibit polymorphic form type I. However, the aspect ratio and crystal size distributions were varied with the increased of cooling rate. A high crystals aspect ratio and narrower CSD (100−900 μm) was obtained at cooling rate of 0.5 °C/min. Thus, can be suggested as the most suitable cooling rate for crystallization of mefenamic acid in ethyl acetate. IOP Publishing 2017-06-09 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/58987/1/58987-Effect%20of%20Cooling%20Rates%20on%20Shape-SCOPUS.pdf application/pdf en http://irep.iium.edu.my/58987/2/58987-Effect%20of%20Cooling%20Rates%20on%20Shape%20and%20Crystal%20Size.pdf application/pdf en http://irep.iium.edu.my/58987/13/58987%20Effect%20of%20Cooling%20Rates%20on%20Shape%20WOS.pdf Abdul Mudalip, S. K. and Adam, Fatmawati and Jamal, Parveen and Abu Bakar, Mohd Rushdi and Amran, Nur Amelia and Sulaiman, Siti Zubaidah and Che Man, Rohaida and Mohd Arshad, Z.I. and Shaarani, Shalyda Md (2017) Effect of cooling rates on shape and crystal size distributions of mefenamic acid polymorph in ethyl acetate. In: The 2nd International Conference on Materials Engineering and Nanotechnology (ICMEN2017), 12th-14th May 2017, Kuala Lumpur, Malaysia. http://iopscience.iop.org/article/10.1088/1757-899X/205/1/012025/pdf 10.1088/1757-899X/205/1/012025
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	T Technology (General)
spellingShingle	T Technology (General) Abdul Mudalip, S. K. Adam, Fatmawati Jamal, Parveen Abu Bakar, Mohd Rushdi Amran, Nur Amelia Sulaiman, Siti Zubaidah Che Man, Rohaida Mohd Arshad, Z.I. Shaarani, Shalyda Md Effect of cooling rates on shape and crystal size distributions of mefenamic acid polymorph in ethyl acetate
description	This study investigate the effect of cooling rates on mefenamic acid crystallisation in ethyl acetate. The cooling rate was varied from 0.2 to 5 °C/min. The in-line conductivity system and turbidity system were employed to detect the onset of the crystallization process. The crystals produced were analysed using optical microscopy and Fourier transform infrared spectroscopy (FTIR). It was found that the crystals produced at different cooling rates were needle-like and exhibit polymorphic form type I. However, the aspect ratio and crystal size distributions were varied with the increased of cooling rate. A high crystals aspect ratio and narrower CSD (100−900 μm) was obtained at cooling rate of 0.5 °C/min. Thus, can be suggested as the most suitable cooling rate for crystallization of mefenamic acid in ethyl acetate.
format	Conference or Workshop Item
author	Abdul Mudalip, S. K. Adam, Fatmawati Jamal, Parveen Abu Bakar, Mohd Rushdi Amran, Nur Amelia Sulaiman, Siti Zubaidah Che Man, Rohaida Mohd Arshad, Z.I. Shaarani, Shalyda Md
author_facet	Abdul Mudalip, S. K. Adam, Fatmawati Jamal, Parveen Abu Bakar, Mohd Rushdi Amran, Nur Amelia Sulaiman, Siti Zubaidah Che Man, Rohaida Mohd Arshad, Z.I. Shaarani, Shalyda Md
author_sort	Abdul Mudalip, S. K.
title	Effect of cooling rates on shape and crystal size distributions of mefenamic acid polymorph in ethyl acetate
title_short	Effect of cooling rates on shape and crystal size distributions of mefenamic acid polymorph in ethyl acetate
title_full	Effect of cooling rates on shape and crystal size distributions of mefenamic acid polymorph in ethyl acetate
title_fullStr	Effect of cooling rates on shape and crystal size distributions of mefenamic acid polymorph in ethyl acetate
title_full_unstemmed	Effect of cooling rates on shape and crystal size distributions of mefenamic acid polymorph in ethyl acetate
title_sort	effect of cooling rates on shape and crystal size distributions of mefenamic acid polymorph in ethyl acetate
publisher	IOP Publishing
publishDate	2017
url	http://irep.iium.edu.my/58987/ http://irep.iium.edu.my/58987/ http://irep.iium.edu.my/58987/ http://irep.iium.edu.my/58987/1/58987-Effect%20of%20Cooling%20Rates%20on%20Shape-SCOPUS.pdf http://irep.iium.edu.my/58987/2/58987-Effect%20of%20Cooling%20Rates%20on%20Shape%20and%20Crystal%20Size.pdf http://irep.iium.edu.my/58987/13/58987%20Effect%20of%20Cooling%20Rates%20on%20Shape%20WOS.pdf
first_indexed	2023-09-18T21:23:29Z
last_indexed	2023-09-18T21:23:29Z
_version_	1777412037018648576

Effect of cooling rates on shape and crystal size distributions of mefenamic acid polymorph in ethyl acetate

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