Effect of cooling rates on shape and crystal size distributions of mefenamic acid polymorph in ethyl acetate
This study investigate the effect of cooling rates on mefenamic acid crystallisation in ethyl acetate. The cooling rate was varied from 0.2 to 5 °C/min. The in-line conductivity system and turbidity system were employed to detect the onset of the crystallization process. The crystals produced wer...
| Main Authors: | , , , , , , , , |
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| Format: | Conference or Workshop Item |
| Language: | English English English |
| Published: |
IOP Publishing
2017
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/58987/ http://irep.iium.edu.my/58987/ http://irep.iium.edu.my/58987/ http://irep.iium.edu.my/58987/1/58987-Effect%20of%20Cooling%20Rates%20on%20Shape-SCOPUS.pdf http://irep.iium.edu.my/58987/2/58987-Effect%20of%20Cooling%20Rates%20on%20Shape%20and%20Crystal%20Size.pdf http://irep.iium.edu.my/58987/13/58987%20Effect%20of%20Cooling%20Rates%20on%20Shape%20WOS.pdf |
| Summary: | This study investigate the effect of cooling rates on mefenamic acid crystallisation in
ethyl acetate. The cooling rate was varied from 0.2 to 5 °C/min. The in-line conductivity
system and turbidity system were employed to detect the onset of the crystallization process.
The crystals produced were analysed using optical microscopy and Fourier transform infrared
spectroscopy (FTIR). It was found that the crystals produced at different cooling rates were
needle-like and exhibit polymorphic form type I. However, the aspect ratio and crystal size
distributions were varied with the increased of cooling rate. A high crystals aspect ratio and
narrower CSD (100−900 μm) was obtained at cooling rate of 0.5 °C/min. Thus, can be
suggested as the most suitable cooling rate for crystallization of mefenamic acid in ethyl
acetate. |
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