Cytotoxicity effects of extracts and essential oil of kaempferia galanga on cervical cancer C33A cell line

The cytotoxicity properties of Kaempferia galanga extracts were studied. Crude extracts of the rhizome were obtained by extraction with methanol (KGM), petroleum ether (KGPE) and ethyl acetate (KGEA). Meanwhile, the essential oil (KGEO) was produced by steam distillation method. The aim of the prese...

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Main Authors:	Omar, Muhammad Nor, Rahman, Siti Muneerah, Ichwan, Solachuddin J. A., Hasali, Nor Hazwani, Rasid, Faridah Abdul, Halim, Farhana Abdul
Format:	Article
Language:	English English English
Published:	Oriental Scientific Publishing Company 2017
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/58879/ http://irep.iium.edu.my/58879/ http://irep.iium.edu.my/58879/ http://irep.iium.edu.my/58879/1/OJC_Vol33_No4_p_1659-1664-2.pdf http://irep.iium.edu.my/58879/2/KAEMFERIA%20CYTOTOXICITY%20Web%20of%20Science%20%5Bv.5.25.1%5D%20-%20Web%20of%20Science%20Core%20Collection%20Full%20Record.pdf http://irep.iium.edu.my/58879/13/Cytotoxicity%20effects%20of%20extracts%20and%20essential%20oil%20of%20kaempferia%20galanga%20on%20cervical%20cancer%20C33A%20cell%20line.pdf

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spelling	iium-588792018-03-19T04:01:55Z http://irep.iium.edu.my/58879/ Cytotoxicity effects of extracts and essential oil of kaempferia galanga on cervical cancer C33A cell line Omar, Muhammad Nor Rahman, Siti Muneerah Ichwan, Solachuddin J. A. Hasali, Nor Hazwani Rasid, Faridah Abdul Halim, Farhana Abdul QD Chemistry The cytotoxicity properties of Kaempferia galanga extracts were studied. Crude extracts of the rhizome were obtained by extraction with methanol (KGM), petroleum ether (KGPE) and ethyl acetate (KGEA). Meanwhile, the essential oil (KGEO) was produced by steam distillation method. The aim of the present work was to screen the cytotoxic activity of K. galanga extracts and essential oil on cervical cancer C33A cell line. The cytotoxic activities were assessed on C33A cell line using MTT and scratch assays. Results of MTT assay showed that KGEA and KGM were the most cytotoxic at 1000 μg mL-1 with cell viabilities of 11 and 14 %, respectively. Lower cytotoxic activities were shown by KGPE and KGEO with 64 and 88 % cell viability, respectively. Meanwhile, KGEA was slightly cytotoxic at concentration of 500 μg mL-1 with cell viability of 70 %. However, all the extracts were able to inhibit or at least slow down cell growth when tested using the scratch assay. It can be concluded that K. galanga seems to have cytotoxic properties and may be used as an anticancer agent. Oriental Scientific Publishing Company 2017-08-31 Article PeerReviewed application/pdf en http://irep.iium.edu.my/58879/1/OJC_Vol33_No4_p_1659-1664-2.pdf application/pdf en http://irep.iium.edu.my/58879/2/KAEMFERIA%20CYTOTOXICITY%20Web%20of%20Science%20%5Bv.5.25.1%5D%20-%20Web%20of%20Science%20Core%20Collection%20Full%20Record.pdf application/pdf en http://irep.iium.edu.my/58879/13/Cytotoxicity%20effects%20of%20extracts%20and%20essential%20oil%20of%20kaempferia%20galanga%20on%20cervical%20cancer%20C33A%20cell%20line.pdf Omar, Muhammad Nor and Rahman, Siti Muneerah and Ichwan, Solachuddin J. A. and Hasali, Nor Hazwani and Rasid, Faridah Abdul and Halim, Farhana Abdul (2017) Cytotoxicity effects of extracts and essential oil of kaempferia galanga on cervical cancer C33A cell line. Oriental Journal of Chemistry, 33 (4). pp. 1659-1664. ISSN 0970-020X E-ISSN 2231-5039 http://www.orientjchem.org/ 10.13005/ojc/330409
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	QD Chemistry
spellingShingle	QD Chemistry Omar, Muhammad Nor Rahman, Siti Muneerah Ichwan, Solachuddin J. A. Hasali, Nor Hazwani Rasid, Faridah Abdul Halim, Farhana Abdul Cytotoxicity effects of extracts and essential oil of kaempferia galanga on cervical cancer C33A cell line
description	The cytotoxicity properties of Kaempferia galanga extracts were studied. Crude extracts of the rhizome were obtained by extraction with methanol (KGM), petroleum ether (KGPE) and ethyl acetate (KGEA). Meanwhile, the essential oil (KGEO) was produced by steam distillation method. The aim of the present work was to screen the cytotoxic activity of K. galanga extracts and essential oil on cervical cancer C33A cell line. The cytotoxic activities were assessed on C33A cell line using MTT and scratch assays. Results of MTT assay showed that KGEA and KGM were the most cytotoxic at 1000 μg mL-1 with cell viabilities of 11 and 14 %, respectively. Lower cytotoxic activities were shown by KGPE and KGEO with 64 and 88 % cell viability, respectively. Meanwhile, KGEA was slightly cytotoxic at concentration of 500 μg mL-1 with cell viability of 70 %. However, all the extracts were able to inhibit or at least slow down cell growth when tested using the scratch assay. It can be concluded that K. galanga seems to have cytotoxic properties and may be used as an anticancer agent.
format	Article
author	Omar, Muhammad Nor Rahman, Siti Muneerah Ichwan, Solachuddin J. A. Hasali, Nor Hazwani Rasid, Faridah Abdul Halim, Farhana Abdul
author_facet	Omar, Muhammad Nor Rahman, Siti Muneerah Ichwan, Solachuddin J. A. Hasali, Nor Hazwani Rasid, Faridah Abdul Halim, Farhana Abdul
author_sort	Omar, Muhammad Nor
title	Cytotoxicity effects of extracts and essential oil of kaempferia galanga on cervical cancer C33A cell line
title_short	Cytotoxicity effects of extracts and essential oil of kaempferia galanga on cervical cancer C33A cell line
title_full	Cytotoxicity effects of extracts and essential oil of kaempferia galanga on cervical cancer C33A cell line
title_fullStr	Cytotoxicity effects of extracts and essential oil of kaempferia galanga on cervical cancer C33A cell line
title_full_unstemmed	Cytotoxicity effects of extracts and essential oil of kaempferia galanga on cervical cancer C33A cell line
title_sort	cytotoxicity effects of extracts and essential oil of kaempferia galanga on cervical cancer c33a cell line
publisher	Oriental Scientific Publishing Company
publishDate	2017
url	http://irep.iium.edu.my/58879/ http://irep.iium.edu.my/58879/ http://irep.iium.edu.my/58879/ http://irep.iium.edu.my/58879/1/OJC_Vol33_No4_p_1659-1664-2.pdf http://irep.iium.edu.my/58879/2/KAEMFERIA%20CYTOTOXICITY%20Web%20of%20Science%20%5Bv.5.25.1%5D%20-%20Web%20of%20Science%20Core%20Collection%20Full%20Record.pdf http://irep.iium.edu.my/58879/13/Cytotoxicity%20effects%20of%20extracts%20and%20essential%20oil%20of%20kaempferia%20galanga%20on%20cervical%20cancer%20C33A%20cell%20line.pdf
first_indexed	2023-09-18T21:23:19Z
last_indexed	2023-09-18T21:23:19Z
_version_	1777412026996359168

Cytotoxicity effects of extracts and essential oil of kaempferia galanga on cervical cancer C33A cell line

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