Relation between apoE gene polymorphism and coronary artery disease in South East and East Asian Countries

Background and objective: Apolipoprotein E (apoE) is a polymorphic protein with vital antioxidant and anti-atherosclerotic effects. Three apoE isoforms exist due to polymorphisms in its gene causing disturbances of lipoproteins metabolism and a probability to develop cardiovascular diseases. The aim...

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Main Authors:	Ibrahim, Wisam Nabeel, Aladzemi, Farah Wahida, Muhammad Musa, Nur Ashikin, Nik Ahmad, Nik Nur Fatnoon, Abdullah, Nor Zamzila, A.Talib, Norlelawati
Format:	Article
Language:	English English
Published:	Science Alert 2017
Subjects:	QP Physiology RA790 Public Health. Hygiene. Preventive Medicine - Mental Health. Mental Illness Prevention
Online Access:	http://irep.iium.edu.my/58859/ http://irep.iium.edu.my/58859/ http://irep.iium.edu.my/58859/ http://irep.iium.edu.my/58859/1/AJE.pdf http://irep.iium.edu.my/58859/8/58859-Relation%20between%20apoE%20gene%20polymorphism%20and%20Coronary%20Artery%20Disease%20in%20South%20East%20and%20East%20Asian%20countries-SCOPUS.pdf

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recordtype	eprints
spelling	iium-588592017-10-24T08:27:14Z http://irep.iium.edu.my/58859/ Relation between apoE gene polymorphism and coronary artery disease in South East and East Asian Countries Ibrahim, Wisam Nabeel Aladzemi, Farah Wahida Muhammad Musa, Nur Ashikin Nik Ahmad, Nik Nur Fatnoon Abdullah, Nor Zamzila A.Talib, Norlelawati QP Physiology RA790 Public Health. Hygiene. Preventive Medicine - Mental Health. Mental Illness Prevention Background and objective: Apolipoprotein E (apoE) is a polymorphic protein with vital antioxidant and anti-atherosclerotic effects. Three apoE isoforms exist due to polymorphisms in its gene causing disturbances of lipoproteins metabolism and a probability to develop cardiovascular diseases. The aim of this study was to assess the association between apoE gene polymorphism and coronary artery disease (CAD) in a Malaysian population sample and to integrate the study findings with other studies to increase the power of the study sample and to make a better understanding about the association between apoE gene polymorphism and CAD in south east & East Asian countries. Methods: The study involved 185 patients with CAD attending HTAA hospital Kuantan, Pahang with 188 unrelated healthy control participants. ApoE gene polymorphism was determined in the participants using polymerase chain reaction – restriction fragment length polymorphism (PCR-RFLP) assay and was validated using direct nucleotide sequencing. SPSS software version 19 and Chi-squared test was used for determination of allele and genotypes association with CAD. Binary logistic regression analysis of apoE genotypes, gender, ethnicity, age, blood pressure, and lipid profile was used to predict probability of developing CAD. In addition, meta-analysis was conducted using Review Manager (Version 5.3.). Results: the preliminary data has shown a non-significant association between apoE genotypes or alleles and CAD. Nevertheless, binary logistic regression analysis has shown a significant association between E3E4 genotype, high blood pressure, male gender & old age as dependant risk factors in the prediction for having CAD. The meta-analysis of studies in Southeast Asia and East Asia region had shown that carriers of the E4 allele are significantly at higher risk to develop CAD [p<0.0001; OR=1.51 (1.24, 1.83) CI=95%; I2=68%]. Conclusion: This study provides an evidence of increased risk to develop CAD among carriers of E4 allele specially if accompanied with high blood pressure, old age with male gender. Science Alert 2017 Article PeerReviewed application/pdf en http://irep.iium.edu.my/58859/1/AJE.pdf application/pdf en http://irep.iium.edu.my/58859/8/58859-Relation%20between%20apoE%20gene%20polymorphism%20and%20Coronary%20Artery%20Disease%20in%20South%20East%20and%20East%20Asian%20countries-SCOPUS.pdf Ibrahim, Wisam Nabeel and Aladzemi, Farah Wahida and Muhammad Musa, Nur Ashikin and Nik Ahmad, Nik Nur Fatnoon and Abdullah, Nor Zamzila and A.Talib, Norlelawati (2017) Relation between apoE gene polymorphism and coronary artery disease in South East and East Asian Countries. Asian Journal of Epidemiology, 10 (2). pp. 54-62. ISSN 1992-1462 E-ISSN 1992-1462 http://scialert.net/qredirect.php?doi=aje.2017.54.62&linkid=pdf 10.3923/aje.2017.54.62
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QP Physiology RA790 Public Health. Hygiene. Preventive Medicine - Mental Health. Mental Illness Prevention
spellingShingle	QP Physiology RA790 Public Health. Hygiene. Preventive Medicine - Mental Health. Mental Illness Prevention Ibrahim, Wisam Nabeel Aladzemi, Farah Wahida Muhammad Musa, Nur Ashikin Nik Ahmad, Nik Nur Fatnoon Abdullah, Nor Zamzila A.Talib, Norlelawati Relation between apoE gene polymorphism and coronary artery disease in South East and East Asian Countries
description	Background and objective: Apolipoprotein E (apoE) is a polymorphic protein with vital antioxidant and anti-atherosclerotic effects. Three apoE isoforms exist due to polymorphisms in its gene causing disturbances of lipoproteins metabolism and a probability to develop cardiovascular diseases. The aim of this study was to assess the association between apoE gene polymorphism and coronary artery disease (CAD) in a Malaysian population sample and to integrate the study findings with other studies to increase the power of the study sample and to make a better understanding about the association between apoE gene polymorphism and CAD in south east & East Asian countries. Methods: The study involved 185 patients with CAD attending HTAA hospital Kuantan, Pahang with 188 unrelated healthy control participants. ApoE gene polymorphism was determined in the participants using polymerase chain reaction – restriction fragment length polymorphism (PCR-RFLP) assay and was validated using direct nucleotide sequencing. SPSS software version 19 and Chi-squared test was used for determination of allele and genotypes association with CAD. Binary logistic regression analysis of apoE genotypes, gender, ethnicity, age, blood pressure, and lipid profile was used to predict probability of developing CAD. In addition, meta-analysis was conducted using Review Manager (Version 5.3.). Results: the preliminary data has shown a non-significant association between apoE genotypes or alleles and CAD. Nevertheless, binary logistic regression analysis has shown a significant association between E3E4 genotype, high blood pressure, male gender & old age as dependant risk factors in the prediction for having CAD. The meta-analysis of studies in Southeast Asia and East Asia region had shown that carriers of the E4 allele are significantly at higher risk to develop CAD [p<0.0001; OR=1.51 (1.24, 1.83) CI=95%; I2=68%]. Conclusion: This study provides an evidence of increased risk to develop CAD among carriers of E4 allele specially if accompanied with high blood pressure, old age with male gender.
format	Article
author	Ibrahim, Wisam Nabeel Aladzemi, Farah Wahida Muhammad Musa, Nur Ashikin Nik Ahmad, Nik Nur Fatnoon Abdullah, Nor Zamzila A.Talib, Norlelawati
author_facet	Ibrahim, Wisam Nabeel Aladzemi, Farah Wahida Muhammad Musa, Nur Ashikin Nik Ahmad, Nik Nur Fatnoon Abdullah, Nor Zamzila A.Talib, Norlelawati
author_sort	Ibrahim, Wisam Nabeel
title	Relation between apoE gene polymorphism and coronary artery disease in South East and East Asian Countries
title_short	Relation between apoE gene polymorphism and coronary artery disease in South East and East Asian Countries
title_full	Relation between apoE gene polymorphism and coronary artery disease in South East and East Asian Countries
title_fullStr	Relation between apoE gene polymorphism and coronary artery disease in South East and East Asian Countries
title_full_unstemmed	Relation between apoE gene polymorphism and coronary artery disease in South East and East Asian Countries
title_sort	relation between apoe gene polymorphism and coronary artery disease in south east and east asian countries
publisher	Science Alert
publishDate	2017
url	http://irep.iium.edu.my/58859/ http://irep.iium.edu.my/58859/ http://irep.iium.edu.my/58859/ http://irep.iium.edu.my/58859/1/AJE.pdf http://irep.iium.edu.my/58859/8/58859-Relation%20between%20apoE%20gene%20polymorphism%20and%20Coronary%20Artery%20Disease%20in%20South%20East%20and%20East%20Asian%20countries-SCOPUS.pdf
first_indexed	2023-09-18T21:23:17Z
last_indexed	2023-09-18T21:23:17Z
_version_	1777412024947441664

Relation between apoE gene polymorphism and coronary artery disease in South East and East Asian Countries

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