Higher titres of thyroid antibodies among the urban & coastal populations of Malaysia

To determine the prevalence of anti-thyroperoxidase (antiTPO) and anti-thyroglobulin (antiTG) and the associated predisposing factors among the Malaysian adult population. A cross sectional study involving 2259 subjects selected from 5 pre-assigned regions which were representatives of the Malaysia...

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Main Authors:	Shahar, Mohammad Arif, Omar, Ahmad Marzuki, Ab Wahab, Norasyikin, Sukor, Norlela, Kamaruddin, Nor Azmi
Format:	Article
Language:	English
Published:	Korean Thyroid Association 2017
Subjects:	R Medicine (General) RC Internal medicine
Online Access:	http://irep.iium.edu.my/58855/ http://irep.iium.edu.my/58855/ http://irep.iium.edu.my/58855/1/ITJ%20thyroid%20antibodies.pdf

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recordtype	eprints
spelling	iium-588552018-01-12T11:18:12Z http://irep.iium.edu.my/58855/ Higher titres of thyroid antibodies among the urban & coastal populations of Malaysia Shahar, Mohammad Arif Omar, Ahmad Marzuki Ab Wahab, Norasyikin Sukor, Norlela Kamaruddin, Nor Azmi R Medicine (General) RC Internal medicine To determine the prevalence of anti-thyroperoxidase (antiTPO) and anti-thyroglobulin (antiTG) and the associated predisposing factors among the Malaysian adult population. A cross sectional study involving 2259 subjects selected from 5 pre-assigned regions which were representatives of the Malaysian socioeconomic and geographical background. Sixty-nine subjects were excluded due to incomplete data. The prevalences of antiTPO and antiTG were determined for 2054 subjects who did not report any history of thyroid diseases nor taking any thyroid medications (disease-free population). Hundred thirty-six subjects with known thyroid disorders were further analysed in terms of their thyroid antibody status. The influence of demographic factors on antiTPO and antiTG titres was also analysed. Positive antiTPO and antiTG were defined as titres above 40 IU/mL. The hormonal assays and thyroid antibodies were performed using the Architect and Immulite systems respectively. The prevalence of positive antiTPO and antiTG were 12.2% and 12.1% respectively. Among the disease-free population, the prevalence of positive antiTPO and antiTG were 10.4% and 10.9% respectively. Among subjects with known thyroid disease, the prevalence of antiTPO and antiTG were 39.0% and 30.1% respectively. Higher prevalence of antiTPO and antiTG was observed females (15.2% and 15.7% respectively). Among the major ethnic groups, Indians had a higher prevalence of antiTPO but not antiTG titres. There was also a trend of higher prevalence of thyroid antibodies in urban and coastal regions of the studies areas. Only 8% and 9% of those with positive antiTPO were hypo- and hyperthyroid respectively. Seven percent and 8% of those with positive antiTG were hypo- and hyperthyroid respectively. The prevalence of antiTPO and antiTG in this population were 12.2% and 12.1% respectively. Higher prevalence of thyroid antibodies was observed in females and Indians. The higher prevalence of thyroid antibodies in urban and coastal areas may be a reflection of iodine availability. Korean Thyroid Association 2017-03 Article PeerReviewed application/pdf en http://irep.iium.edu.my/58855/1/ITJ%20thyroid%20antibodies.pdf Shahar, Mohammad Arif and Omar, Ahmad Marzuki and Ab Wahab, Norasyikin and Sukor, Norlela and Kamaruddin, Nor Azmi (2017) Higher titres of thyroid antibodies among the urban & coastal populations of Malaysia. International Journal of Thyroidology, 10 (Suppl. 1). S209-S209. ISSN 2384-3799 E-ISSN 2466-1899 http://www.ijthyroid.org/journal/list.html?pn=mostread
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General) RC Internal medicine
spellingShingle	R Medicine (General) RC Internal medicine Shahar, Mohammad Arif Omar, Ahmad Marzuki Ab Wahab, Norasyikin Sukor, Norlela Kamaruddin, Nor Azmi Higher titres of thyroid antibodies among the urban & coastal populations of Malaysia
description	To determine the prevalence of anti-thyroperoxidase (antiTPO) and anti-thyroglobulin (antiTG) and the associated predisposing factors among the Malaysian adult population. A cross sectional study involving 2259 subjects selected from 5 pre-assigned regions which were representatives of the Malaysian socioeconomic and geographical background. Sixty-nine subjects were excluded due to incomplete data. The prevalences of antiTPO and antiTG were determined for 2054 subjects who did not report any history of thyroid diseases nor taking any thyroid medications (disease-free population). Hundred thirty-six subjects with known thyroid disorders were further analysed in terms of their thyroid antibody status. The influence of demographic factors on antiTPO and antiTG titres was also analysed. Positive antiTPO and antiTG were defined as titres above 40 IU/mL. The hormonal assays and thyroid antibodies were performed using the Architect and Immulite systems respectively. The prevalence of positive antiTPO and antiTG were 12.2% and 12.1% respectively. Among the disease-free population, the prevalence of positive antiTPO and antiTG were 10.4% and 10.9% respectively. Among subjects with known thyroid disease, the prevalence of antiTPO and antiTG were 39.0% and 30.1% respectively. Higher prevalence of antiTPO and antiTG was observed females (15.2% and 15.7% respectively). Among the major ethnic groups, Indians had a higher prevalence of antiTPO but not antiTG titres. There was also a trend of higher prevalence of thyroid antibodies in urban and coastal regions of the studies areas. Only 8% and 9% of those with positive antiTPO were hypo- and hyperthyroid respectively. Seven percent and 8% of those with positive antiTG were hypo- and hyperthyroid respectively. The prevalence of antiTPO and antiTG in this population were 12.2% and 12.1% respectively. Higher prevalence of thyroid antibodies was observed in females and Indians. The higher prevalence of thyroid antibodies in urban and coastal areas may be a reflection of iodine availability.
format	Article
author	Shahar, Mohammad Arif Omar, Ahmad Marzuki Ab Wahab, Norasyikin Sukor, Norlela Kamaruddin, Nor Azmi
author_facet	Shahar, Mohammad Arif Omar, Ahmad Marzuki Ab Wahab, Norasyikin Sukor, Norlela Kamaruddin, Nor Azmi
author_sort	Shahar, Mohammad Arif
title	Higher titres of thyroid antibodies among the urban & coastal populations of Malaysia
title_short	Higher titres of thyroid antibodies among the urban & coastal populations of Malaysia
title_full	Higher titres of thyroid antibodies among the urban & coastal populations of Malaysia
title_fullStr	Higher titres of thyroid antibodies among the urban & coastal populations of Malaysia
title_full_unstemmed	Higher titres of thyroid antibodies among the urban & coastal populations of Malaysia
title_sort	higher titres of thyroid antibodies among the urban & coastal populations of malaysia
publisher	Korean Thyroid Association
publishDate	2017
url	http://irep.iium.edu.my/58855/ http://irep.iium.edu.my/58855/ http://irep.iium.edu.my/58855/1/ITJ%20thyroid%20antibodies.pdf
first_indexed	2023-09-18T21:23:17Z
last_indexed	2023-09-18T21:23:17Z
_version_	1777412024511234048

Higher titres of thyroid antibodies among the urban & coastal populations of Malaysia

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