Development of a binary carrier system consisting polyethylene glycol 4000 - ethyl cellulose for ibuprofen solid dispersion

Background and Objective: One of the established strategies to improve solubility and dissolution rate of poorly water-soluble drugs is solid dispersion (SD). Polyethylene glycol (PEG) is used as common carrier despite its stability problem which may be overcome by the addition of hydrophobic poly...

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Main Authors:	Algadar, Gada Sulaiman, May, Kyaw Oo, Sengupta, Pinaki Ranjan, Mandal, Uttam Kumar, Md. Jaffri, Juliana, Chatterjee, Bappaditya
Format:	Article
Language:	English
Published:	Wolters Kluwer 2017
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/58718/ http://irep.iium.edu.my/58718/ http://irep.iium.edu.my/58718/ http://irep.iium.edu.my/58718/1/58718_Development%20of%20a%20binary%20carrier%20system%20consisting.pdf

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spelling	iium-587182018-03-19T05:55:54Z http://irep.iium.edu.my/58718/ Development of a binary carrier system consisting polyethylene glycol 4000 - ethyl cellulose for ibuprofen solid dispersion Algadar, Gada Sulaiman May, Kyaw Oo Sengupta, Pinaki Ranjan Mandal, Uttam Kumar Md. Jaffri, Juliana Chatterjee, Bappaditya RS Pharmacy and materia medica Background and Objective: One of the established strategies to improve solubility and dissolution rate of poorly water-soluble drugs is solid dispersion (SD). Polyethylene glycol (PEG) is used as common carrier despite its stability problem which may be overcome by the addition of hydrophobic polymer. The present research aims to develop an SD formulation with ibuprofen, a poor water-soluble BCS Class II drug as active pharmaceutical ingredient (API) and PEG 4000-ethyl cellulose (EC) as binary carrier. Methods: Melt mixing SD method was employed using a ratio of API: binary carrier (1:3.5 w/w) (SDPE). Another SD was prepared using only PEG (SDP) as a carrier for comparative study. The developed formulation was evaluated using optical microscopy, scanning electron microscopy (SEM), determination of moisture content, differential scanning calorimetry (DSC), in vitro dissolution test, attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) and flow properties. Results: SEM and DSC indicated the conversion of crystalline ibuprofen to fine partly amorphous solid dispersion, which is responsible for the increase in dissolution rate of SD than a physical mixture. The release characteristics within 1 h from the higher to the lower value were the SDPE > SDP > physical mixture. Flow property evaluation using the angle of repose showed no difference between SD and PM. However, by Carr index and Hausner ratio, the flow properties of SDPE was excellent. Conclusion: The SD formulation with the PEG 4000-EC carrier can be effective to enhance in vitro dissolution of ibuprofen immediate release dosage form. Wolters Kluwer 2017-10-17 Article PeerReviewed application/pdf en http://irep.iium.edu.my/58718/1/58718_Development%20of%20a%20binary%20carrier%20system%20consisting.pdf Algadar, Gada Sulaiman and May, Kyaw Oo and Sengupta, Pinaki Ranjan and Mandal, Uttam Kumar and Md. Jaffri, Juliana and Chatterjee, Bappaditya (2017) Development of a binary carrier system consisting polyethylene glycol 4000 - ethyl cellulose for ibuprofen solid dispersion. International Journal of Pharmaceutical Investigation, 7 (3). pp. 142-148. ISSN 2230-973X E-ISSN 2230-9713 http://www.jpionline.org/temp/PharmInvestigations73142-6578907_014938.pdf 10.4103/jphi.JPHI_54_17
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Algadar, Gada Sulaiman May, Kyaw Oo Sengupta, Pinaki Ranjan Mandal, Uttam Kumar Md. Jaffri, Juliana Chatterjee, Bappaditya Development of a binary carrier system consisting polyethylene glycol 4000 - ethyl cellulose for ibuprofen solid dispersion
description	Background and Objective: One of the established strategies to improve solubility and dissolution rate of poorly water-soluble drugs is solid dispersion (SD). Polyethylene glycol (PEG) is used as common carrier despite its stability problem which may be overcome by the addition of hydrophobic polymer. The present research aims to develop an SD formulation with ibuprofen, a poor water-soluble BCS Class II drug as active pharmaceutical ingredient (API) and PEG 4000-ethyl cellulose (EC) as binary carrier. Methods: Melt mixing SD method was employed using a ratio of API: binary carrier (1:3.5 w/w) (SDPE). Another SD was prepared using only PEG (SDP) as a carrier for comparative study. The developed formulation was evaluated using optical microscopy, scanning electron microscopy (SEM), determination of moisture content, differential scanning calorimetry (DSC), in vitro dissolution test, attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) and flow properties. Results: SEM and DSC indicated the conversion of crystalline ibuprofen to fine partly amorphous solid dispersion, which is responsible for the increase in dissolution rate of SD than a physical mixture. The release characteristics within 1 h from the higher to the lower value were the SDPE > SDP > physical mixture. Flow property evaluation using the angle of repose showed no difference between SD and PM. However, by Carr index and Hausner ratio, the flow properties of SDPE was excellent. Conclusion: The SD formulation with the PEG 4000-EC carrier can be effective to enhance in vitro dissolution of ibuprofen immediate release dosage form.
format	Article
author	Algadar, Gada Sulaiman May, Kyaw Oo Sengupta, Pinaki Ranjan Mandal, Uttam Kumar Md. Jaffri, Juliana Chatterjee, Bappaditya
author_facet	Algadar, Gada Sulaiman May, Kyaw Oo Sengupta, Pinaki Ranjan Mandal, Uttam Kumar Md. Jaffri, Juliana Chatterjee, Bappaditya
author_sort	Algadar, Gada Sulaiman
title	Development of a binary carrier system consisting polyethylene glycol 4000 - ethyl cellulose for ibuprofen solid dispersion
title_short	Development of a binary carrier system consisting polyethylene glycol 4000 - ethyl cellulose for ibuprofen solid dispersion
title_full	Development of a binary carrier system consisting polyethylene glycol 4000 - ethyl cellulose for ibuprofen solid dispersion
title_fullStr	Development of a binary carrier system consisting polyethylene glycol 4000 - ethyl cellulose for ibuprofen solid dispersion
title_full_unstemmed	Development of a binary carrier system consisting polyethylene glycol 4000 - ethyl cellulose for ibuprofen solid dispersion
title_sort	development of a binary carrier system consisting polyethylene glycol 4000 - ethyl cellulose for ibuprofen solid dispersion
publisher	Wolters Kluwer
publishDate	2017
url	http://irep.iium.edu.my/58718/ http://irep.iium.edu.my/58718/ http://irep.iium.edu.my/58718/ http://irep.iium.edu.my/58718/1/58718_Development%20of%20a%20binary%20carrier%20system%20consisting.pdf
first_indexed	2023-09-18T21:23:03Z
last_indexed	2023-09-18T21:23:03Z
_version_	1777412010026205184

Development of a binary carrier system consisting polyethylene glycol 4000 - ethyl cellulose for ibuprofen solid dispersion

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