Development of a binary carrier system consisting polyethylene glycol 4000 - ethyl cellulose for ibuprofen solid dispersion
Background and Objective: One of the established strategies to improve solubility and dissolution rate of poorly water-soluble drugs is solid dispersion (SD). Polyethylene glycol (PEG) is used as common carrier despite its stability problem which may be overcome by the addition of hydrophobic poly...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2017
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/58718/ http://irep.iium.edu.my/58718/ http://irep.iium.edu.my/58718/ http://irep.iium.edu.my/58718/1/58718_Development%20of%20a%20binary%20carrier%20system%20consisting.pdf |
| Summary: | Background and Objective: One of the established strategies to improve solubility and dissolution rate of
poorly water-soluble drugs is solid dispersion (SD). Polyethylene glycol (PEG) is used as common carrier
despite its stability problem which may be overcome by the addition of hydrophobic polymer. The present
research aims to develop an SD formulation with ibuprofen, a poor water-soluble BCS Class II drug as active
pharmaceutical ingredient (API) and PEG 4000-ethyl cellulose (EC) as binary carrier.
Methods: Melt mixing SD method was employed using a ratio of API: binary carrier (1:3.5 w/w) (SDPE).
Another SD was prepared using only PEG (SDP) as a carrier for comparative study. The developed formulation
was evaluated using optical microscopy, scanning electron microscopy (SEM), determination of moisture
content, differential scanning calorimetry (DSC), in vitro dissolution test, attenuated total reflection-Fourier
transform infrared spectroscopy (ATR-FTIR) and flow properties.
Results: SEM and DSC indicated the conversion of crystalline ibuprofen to fine partly amorphous solid
dispersion, which is responsible for the increase in dissolution rate of SD than a physical mixture. The release
characteristics within 1 h from the higher to the lower value were the SDPE > SDP > physical mixture. Flow
property evaluation using the angle of repose showed no difference between SD and PM. However, by Carr
index and Hausner ratio, the flow properties of SDPE was excellent.
Conclusion: The SD formulation with the PEG 4000-EC carrier can be effective to enhance in vitro dissolution
of ibuprofen immediate release dosage form. |
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