Safety of the concurrent use of gabapentin and carbamazepine at moderate therapeutic doses
This study investigated the safety of concurrently administering different therapeutic doses of gabapentin (GBP) and carbamazepine (CBZ) on histopathological features and biochemical parameters of murine kidney and liver. Thirty five adult, female Sprague-Dawley rats were prepared and divided into...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
College of Pharmacists of Buenos Aires Province, Argentina
2017
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/58694/ http://irep.iium.edu.my/58694/ http://irep.iium.edu.my/58694/7/Latin_American_Journal_of_Pharmacy_36_11_page_2278.pdf http://irep.iium.edu.my/58694/13/58964-Safety%20of%20the%20concurrent%20use%20of%20gabapentin-SCOPUS.pdf |
| Summary: | This study investigated the safety of concurrently administering different therapeutic doses of
gabapentin (GBP) and carbamazepine (CBZ) on histopathological features and biochemical parameters of
murine kidney and liver. Thirty five adult, female Sprague-Dawley rats were prepared and divided into
five groups. Four drug regimens, using therapeutic doses calculated from human doses scaled by body
surface area, were administered and any effects on kidney and liver biochemical parameters and
histopathology were determined. Concurrent therapeutic administration of GBP and CBZ at high doses
may produce adverse effects, but maintaining a moderate dose appears safe and may be appropriate,
causing fewer side effects than high doses of a single drug or high dose combination therapy. Considera-
tion should be given to the total drug load than to the individual doses of each medication. Combining
GBP and CBZ in a specific ratio may enable the doses of each to be reduced, which may reduce adverse
effects from combination treatments. |
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