Incorporation of carbopol to palm olein based analgesic cream: effect on formulation characteristics
The purpose of the investigation was to incorporate carbopol gel with palm olein based emulsion and to investigate the effect of such incorporation on formulation characteristics. A palm olein based emulsion was formulated followed by addition of carbopol 940 to it. The critical parameters of inco...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English English English |
| Published: |
Latin American Journal of Pharmacy
2017
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/58691/ http://irep.iium.edu.my/58691/1/Galley_Proof_LAJP_5376_17%20%282%29.pdf http://irep.iium.edu.my/58691/13/Incorporation%20of%20carbopol%20to%20palm%20olein%20based%20analgesic%20cream%20effect%20on%20formulation%20characteristics.pdf http://irep.iium.edu.my/58691/18/58691_Incorporation%20of%20carbopol%20to%20palm%20olein.pdf |
| id |
iium-58691 |
|---|---|
| recordtype |
eprints |
| spelling |
iium-586912018-03-20T02:26:14Z http://irep.iium.edu.my/58691/ Incorporation of carbopol to palm olein based analgesic cream: effect on formulation characteristics Win, Thazin Rajagopal, JeevanRaj Mandal, Uttam Kumar Sengupta, Pinaki Chatterjee, Bappaditya RS Pharmacy and materia medica The purpose of the investigation was to incorporate carbopol gel with palm olein based emulsion and to investigate the effect of such incorporation on formulation characteristics. A palm olein based emulsion was formulated followed by addition of carbopol 940 to it. The critical parameters of incorporating carbopol in bench scale level were checked. The developed palm olein-carbopol based analgesic cream was analyzed for pH, zeta potential, viscosity, rheological property and forced centrifugation.Incorporation of 0.3% of carbopol gel (1% w/w) helps to maintain the viscosity and stability. pH and zeta potential of palm olein-carbopol combined cream was within range of 6.90 to 7.20 and -23.1 to -74.9, respectively. Combination of palm olein based emulsion and carbopol would be a suitable option for topical cream formulation. The pH of carbopol gel and method of mixing with the palm olein based emulsion had crucial effects on phase separation of the product. Latin American Journal of Pharmacy 2017-09 Article PeerReviewed application/pdf en http://irep.iium.edu.my/58691/1/Galley_Proof_LAJP_5376_17%20%282%29.pdf application/pdf en http://irep.iium.edu.my/58691/13/Incorporation%20of%20carbopol%20to%20palm%20olein%20based%20analgesic%20cream%20effect%20on%20formulation%20characteristics.pdf application/pdf en http://irep.iium.edu.my/58691/18/58691_Incorporation%20of%20carbopol%20to%20palm%20olein.pdf Win, Thazin and Rajagopal, JeevanRaj and Mandal, Uttam Kumar and Sengupta, Pinaki and Chatterjee, Bappaditya (2017) Incorporation of carbopol to palm olein based analgesic cream: effect on formulation characteristics. Latin American Journal of Pharmacy, 36 (11). pp. 2144-2155. ISSN 0326 2383 E-ISSN 2362-3853 |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English English English |
| topic |
RS Pharmacy and materia medica |
| spellingShingle |
RS Pharmacy and materia medica Win, Thazin Rajagopal, JeevanRaj Mandal, Uttam Kumar Sengupta, Pinaki Chatterjee, Bappaditya Incorporation of carbopol to palm olein based analgesic cream: effect on formulation characteristics |
| description |
The purpose of the investigation was to incorporate carbopol gel with palm olein based emulsion
and to investigate the effect of such incorporation on formulation characteristics. A palm olein based
emulsion was formulated followed by addition of carbopol 940 to it. The critical parameters of incorporating
carbopol in bench scale level were checked. The developed palm olein-carbopol based analgesic cream
was analyzed for pH, zeta potential, viscosity, rheological property and forced centrifugation.Incorporation
of 0.3% of carbopol gel (1% w/w) helps to maintain the viscosity and stability. pH and zeta potential
of palm olein-carbopol combined cream was within range of 6.90 to 7.20 and -23.1 to -74.9, respectively.
Combination of palm olein based emulsion and carbopol would be a suitable option for topical cream formulation.
The pH of carbopol gel and method of mixing with the palm olein based emulsion had crucial effects
on phase separation of the product. |
| format |
Article |
| author |
Win, Thazin Rajagopal, JeevanRaj Mandal, Uttam Kumar Sengupta, Pinaki Chatterjee, Bappaditya |
| author_facet |
Win, Thazin Rajagopal, JeevanRaj Mandal, Uttam Kumar Sengupta, Pinaki Chatterjee, Bappaditya |
| author_sort |
Win, Thazin |
| title |
Incorporation of carbopol to palm olein based analgesic cream: effect on formulation characteristics |
| title_short |
Incorporation of carbopol to palm olein based analgesic cream: effect on formulation characteristics |
| title_full |
Incorporation of carbopol to palm olein based analgesic cream: effect on formulation characteristics |
| title_fullStr |
Incorporation of carbopol to palm olein based analgesic cream: effect on formulation characteristics |
| title_full_unstemmed |
Incorporation of carbopol to palm olein based analgesic cream: effect on formulation characteristics |
| title_sort |
incorporation of carbopol to palm olein based analgesic cream: effect on formulation characteristics |
| publisher |
Latin American Journal of Pharmacy |
| publishDate |
2017 |
| url |
http://irep.iium.edu.my/58691/ http://irep.iium.edu.my/58691/1/Galley_Proof_LAJP_5376_17%20%282%29.pdf http://irep.iium.edu.my/58691/13/Incorporation%20of%20carbopol%20to%20palm%20olein%20based%20analgesic%20cream%20effect%20on%20formulation%20characteristics.pdf http://irep.iium.edu.my/58691/18/58691_Incorporation%20of%20carbopol%20to%20palm%20olein.pdf |
| first_indexed |
2023-09-18T21:23:01Z |
| last_indexed |
2023-09-18T21:23:01Z |
| _version_ |
1777412007484456960 |