Incorporation of carbopol to palm olein based analgesic cream: effect on formulation characteristics
The purpose of the investigation was to incorporate carbopol gel with palm olein based emulsion and to investigate the effect of such incorporation on formulation characteristics. A palm olein based emulsion was formulated followed by addition of carbopol 940 to it. The critical parameters of inco...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English English English |
| Published: |
Latin American Journal of Pharmacy
2017
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/58691/ http://irep.iium.edu.my/58691/1/Galley_Proof_LAJP_5376_17%20%282%29.pdf http://irep.iium.edu.my/58691/13/Incorporation%20of%20carbopol%20to%20palm%20olein%20based%20analgesic%20cream%20effect%20on%20formulation%20characteristics.pdf http://irep.iium.edu.my/58691/18/58691_Incorporation%20of%20carbopol%20to%20palm%20olein.pdf |
| Summary: | The purpose of the investigation was to incorporate carbopol gel with palm olein based emulsion
and to investigate the effect of such incorporation on formulation characteristics. A palm olein based
emulsion was formulated followed by addition of carbopol 940 to it. The critical parameters of incorporating
carbopol in bench scale level were checked. The developed palm olein-carbopol based analgesic cream
was analyzed for pH, zeta potential, viscosity, rheological property and forced centrifugation.Incorporation
of 0.3% of carbopol gel (1% w/w) helps to maintain the viscosity and stability. pH and zeta potential
of palm olein-carbopol combined cream was within range of 6.90 to 7.20 and -23.1 to -74.9, respectively.
Combination of palm olein based emulsion and carbopol would be a suitable option for topical cream formulation.
The pH of carbopol gel and method of mixing with the palm olein based emulsion had crucial effects
on phase separation of the product. |
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