Clinical and cytogenetic profiles of children with autism in Kuantan Pahang

Introduction: Autism spectrum disorder (ASD) is a group of neurodevelopmental disorder. The aetiology is not known in 75 to 80 percent of patients while in 20 to 25 percent a genetic cause is identified. There are very few studies on cytogenetic profile of ASD being carried out locally. This cross-s...

Full description

Bibliographic Details
Main Authors:	Mat Zin, Nora, Muhammad, Naznin
Format:	Article
Language:	English English
Published:	Intenational Islamic University Malaysia 2016
Subjects:	R Medicine (General) RB Pathology RZ400 Mental healing
Online Access:	http://irep.iium.edu.my/58672/ http://irep.iium.edu.my/58672/ http://irep.iium.edu.my/58672/1/07.%20MRS2016-ABSTRACT-BOOK-56.pdf http://irep.iium.edu.my/58672/7/17.%20IMJM-SUPPLEMENT-ISSUE.jpg

id	iium-58672
recordtype	eprints
spelling	iium-586722018-02-26T08:25:36Z http://irep.iium.edu.my/58672/ Clinical and cytogenetic profiles of children with autism in Kuantan Pahang Mat Zin, Nora Muhammad, Naznin R Medicine (General) RB Pathology RZ400 Mental healing Introduction: Autism spectrum disorder (ASD) is a group of neurodevelopmental disorder. The aetiology is not known in 75 to 80 percent of patients while in 20 to 25 percent a genetic cause is identified. There are very few studies on cytogenetic profile of ASD being carried out locally. This cross-sectional study was conducted to examine the clinical and cytogenetic profiles of paediatric ASD patients attending the Kuantan branch, National Autistic Society of Malaysia School. Methods: All paediatric patients (up to 18 years of age) attending the school in the year 2009/2010 were recruited. Clinical data was obtained by interviewing the guardians and assessment of the patients. Peripheral blood samples were collected for cytogenetic analysis. Results: Guardians of 14 out of 24 patients (58.3%) agreed for their children to be enrolled into the study. The age range was 5 to 12 years of age. The diagnostic subgroups were autistic disorder (13/14 patients) and Asperger syndrome (1/14). Approximately 80% had learning disability and history of allergy. Five patients had hyperactivity and none had history of seizures. There were family histories of developmental delay, mental retardation, epilepsy, psychiatric disorders and allergy. No structural or numerical chromosomal abnormality was detected. Conclusions: Although no cytogenetic abnormalities were identified, most probably due to the small sample size, it is crucial that genetic studies, including molecular genetic be explored as they would provide useful clinical insights and enhance understanding of the pathogenesis. KEYWORDS: Cytogenetic, Autisme Intenational Islamic University Malaysia 2016 Article PeerReviewed application/pdf en http://irep.iium.edu.my/58672/1/07.%20MRS2016-ABSTRACT-BOOK-56.pdf application/pdf en http://irep.iium.edu.my/58672/7/17.%20IMJM-SUPPLEMENT-ISSUE.jpg Mat Zin, Nora and Muhammad, Naznin (2016) Clinical and cytogenetic profiles of children with autism in Kuantan Pahang. International Medical Journal Malaysia, 15. p. 56. ISSN 1823-4631 http://iiumedic.net/imjm/v1/download/Volume%2015%20Supplement/MRS2016-ABSTRACT-BOOK-56.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	R Medicine (General) RB Pathology RZ400 Mental healing
spellingShingle	R Medicine (General) RB Pathology RZ400 Mental healing Mat Zin, Nora Muhammad, Naznin Clinical and cytogenetic profiles of children with autism in Kuantan Pahang
description	Introduction: Autism spectrum disorder (ASD) is a group of neurodevelopmental disorder. The aetiology is not known in 75 to 80 percent of patients while in 20 to 25 percent a genetic cause is identified. There are very few studies on cytogenetic profile of ASD being carried out locally. This cross-sectional study was conducted to examine the clinical and cytogenetic profiles of paediatric ASD patients attending the Kuantan branch, National Autistic Society of Malaysia School. Methods: All paediatric patients (up to 18 years of age) attending the school in the year 2009/2010 were recruited. Clinical data was obtained by interviewing the guardians and assessment of the patients. Peripheral blood samples were collected for cytogenetic analysis. Results: Guardians of 14 out of 24 patients (58.3%) agreed for their children to be enrolled into the study. The age range was 5 to 12 years of age. The diagnostic subgroups were autistic disorder (13/14 patients) and Asperger syndrome (1/14). Approximately 80% had learning disability and history of allergy. Five patients had hyperactivity and none had history of seizures. There were family histories of developmental delay, mental retardation, epilepsy, psychiatric disorders and allergy. No structural or numerical chromosomal abnormality was detected. Conclusions: Although no cytogenetic abnormalities were identified, most probably due to the small sample size, it is crucial that genetic studies, including molecular genetic be explored as they would provide useful clinical insights and enhance understanding of the pathogenesis. KEYWORDS: Cytogenetic, Autisme
format	Article
author	Mat Zin, Nora Muhammad, Naznin
author_facet	Mat Zin, Nora Muhammad, Naznin
author_sort	Mat Zin, Nora
title	Clinical and cytogenetic profiles of children with autism in Kuantan Pahang
title_short	Clinical and cytogenetic profiles of children with autism in Kuantan Pahang
title_full	Clinical and cytogenetic profiles of children with autism in Kuantan Pahang
title_fullStr	Clinical and cytogenetic profiles of children with autism in Kuantan Pahang
title_full_unstemmed	Clinical and cytogenetic profiles of children with autism in Kuantan Pahang
title_sort	clinical and cytogenetic profiles of children with autism in kuantan pahang
publisher	Intenational Islamic University Malaysia
publishDate	2016
url	http://irep.iium.edu.my/58672/ http://irep.iium.edu.my/58672/ http://irep.iium.edu.my/58672/1/07.%20MRS2016-ABSTRACT-BOOK-56.pdf http://irep.iium.edu.my/58672/7/17.%20IMJM-SUPPLEMENT-ISSUE.jpg
first_indexed	2023-09-18T21:22:59Z
last_indexed	2023-09-18T21:22:59Z
_version_	1777412006216728576

Clinical and cytogenetic profiles of children with autism in Kuantan Pahang

Similar Items