Higher prevalence of goitre but not thyroid nodules among the younger age groups in Malaysia: Results of a nationwide study into thyroid disorders

To determine the prevalence of goitre and thyroid nodule(s) in the Malaysian adult population This is a cross sectional study involving 2259 subjects selected from 5 pre-assigned regions which were representatives of the Malaysian socioeconomic and geographical background. Sixty-nine subjects were...

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Main Authors:	Shahar, Mohammad Arif, Omar, Ahmad Marzuki, Ab Wahab, Norasyikin, Sukor, Norlela, Kamaruddin, Nor Azmi
Format:	Article
Language:	English
Published:	Korean Thyroid Association 2017
Subjects:	R Medicine (General) RC Internal medicine
Online Access:	http://irep.iium.edu.my/58584/ http://irep.iium.edu.my/58584/ http://irep.iium.edu.my/58584/7/58584-edited.pdf

id	iium-58584
recordtype	eprints
spelling	iium-585842017-10-03T03:19:52Z http://irep.iium.edu.my/58584/ Higher prevalence of goitre but not thyroid nodules among the younger age groups in Malaysia: Results of a nationwide study into thyroid disorders Shahar, Mohammad Arif Omar, Ahmad Marzuki Ab Wahab, Norasyikin Sukor, Norlela Kamaruddin, Nor Azmi R Medicine (General) RC Internal medicine To determine the prevalence of goitre and thyroid nodule(s) in the Malaysian adult population This is a cross sectional study involving 2259 subjects selected from 5 pre-assigned regions which were representatives of the Malaysian socioeconomic and geographical background. Sixty-nine subjects were excluded due to incomplete data. The prevalences of goitre and thyroid nodule(s) were determined in 2054 subjects who did not report any history of thyroid diseases nor taking any thyroid medications (disease-free population). Hundred thirty-six subjects with known thyroid disorders were analyzed in detail. The presence of goiter or thyroid nodule(s) was determined by trained specialist physicians and positive findings were corroborated by another investigator. The WHO grading of goitre (2014) was used. The hormonal assays and thyroid antibodies were performed using the Architect and Immulite systems respectively. The prevalence of grade 1 and grade 2 goiter were 5.0% and 4.3% respectively. The prevalence of thyroid nodule(s) was only 3.6%. Seventy-two percent of goiters and 68% of thyroid nodule(s) were new findings. The prevalence of goitre and thyroid nodule(s) were higher in females in both the total population (13.2% and 4.6%) and disease-free population (9.3% and 3.3%). Goitre was more prevalent in those aged less than 45 years (12.1% vs 8.0%). Indians had a higher prevalence of grade 2 goitres. The presence of goitre was associated with positive anti-TPO and anti-TG antibodies. Regions located in rural and inland areas had significantly higher prevalence of goitre but not that of thyroid nodule(s). These areas had been shown to suffer from some degree of iodine insufficiency. The prevalence of goitre and thyroid nodule(s) in this population was 9.3% and 3.6%, respectively. Higher prevalence of goitre was observed in females, younger age group and Indians. Higher prevalence of goitre in rural and inland areas may be indicative of iodine insuffficiency. Korean Thyroid Association 2017 Article PeerReviewed application/pdf en http://irep.iium.edu.my/58584/7/58584-edited.pdf Shahar, Mohammad Arif and Omar, Ahmad Marzuki and Ab Wahab, Norasyikin and Sukor, Norlela and Kamaruddin, Nor Azmi (2017) Higher prevalence of goitre but not thyroid nodules among the younger age groups in Malaysia: Results of a nationwide study into thyroid disorders. International Journal of Thyroidology, 10 (Supplement 1). S128-S128. ISSN 2384-3799 E-ISSN 2466-1899 http://www.ijthyroid.org/main.html
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General) RC Internal medicine
spellingShingle	R Medicine (General) RC Internal medicine Shahar, Mohammad Arif Omar, Ahmad Marzuki Ab Wahab, Norasyikin Sukor, Norlela Kamaruddin, Nor Azmi Higher prevalence of goitre but not thyroid nodules among the younger age groups in Malaysia: Results of a nationwide study into thyroid disorders
description	To determine the prevalence of goitre and thyroid nodule(s) in the Malaysian adult population This is a cross sectional study involving 2259 subjects selected from 5 pre-assigned regions which were representatives of the Malaysian socioeconomic and geographical background. Sixty-nine subjects were excluded due to incomplete data. The prevalences of goitre and thyroid nodule(s) were determined in 2054 subjects who did not report any history of thyroid diseases nor taking any thyroid medications (disease-free population). Hundred thirty-six subjects with known thyroid disorders were analyzed in detail. The presence of goiter or thyroid nodule(s) was determined by trained specialist physicians and positive findings were corroborated by another investigator. The WHO grading of goitre (2014) was used. The hormonal assays and thyroid antibodies were performed using the Architect and Immulite systems respectively. The prevalence of grade 1 and grade 2 goiter were 5.0% and 4.3% respectively. The prevalence of thyroid nodule(s) was only 3.6%. Seventy-two percent of goiters and 68% of thyroid nodule(s) were new findings. The prevalence of goitre and thyroid nodule(s) were higher in females in both the total population (13.2% and 4.6%) and disease-free population (9.3% and 3.3%). Goitre was more prevalent in those aged less than 45 years (12.1% vs 8.0%). Indians had a higher prevalence of grade 2 goitres. The presence of goitre was associated with positive anti-TPO and anti-TG antibodies. Regions located in rural and inland areas had significantly higher prevalence of goitre but not that of thyroid nodule(s). These areas had been shown to suffer from some degree of iodine insufficiency. The prevalence of goitre and thyroid nodule(s) in this population was 9.3% and 3.6%, respectively. Higher prevalence of goitre was observed in females, younger age group and Indians. Higher prevalence of goitre in rural and inland areas may be indicative of iodine insuffficiency.
format	Article
author	Shahar, Mohammad Arif Omar, Ahmad Marzuki Ab Wahab, Norasyikin Sukor, Norlela Kamaruddin, Nor Azmi
author_facet	Shahar, Mohammad Arif Omar, Ahmad Marzuki Ab Wahab, Norasyikin Sukor, Norlela Kamaruddin, Nor Azmi
author_sort	Shahar, Mohammad Arif
title	Higher prevalence of goitre but not thyroid nodules among the younger age groups in Malaysia: Results of a nationwide study into thyroid disorders
title_short	Higher prevalence of goitre but not thyroid nodules among the younger age groups in Malaysia: Results of a nationwide study into thyroid disorders
title_full	Higher prevalence of goitre but not thyroid nodules among the younger age groups in Malaysia: Results of a nationwide study into thyroid disorders
title_fullStr	Higher prevalence of goitre but not thyroid nodules among the younger age groups in Malaysia: Results of a nationwide study into thyroid disorders
title_full_unstemmed	Higher prevalence of goitre but not thyroid nodules among the younger age groups in Malaysia: Results of a nationwide study into thyroid disorders
title_sort	higher prevalence of goitre but not thyroid nodules among the younger age groups in malaysia: results of a nationwide study into thyroid disorders
publisher	Korean Thyroid Association
publishDate	2017
url	http://irep.iium.edu.my/58584/ http://irep.iium.edu.my/58584/ http://irep.iium.edu.my/58584/7/58584-edited.pdf
first_indexed	2023-09-18T21:22:52Z
last_indexed	2023-09-18T21:22:52Z
_version_	1777411998493966336

Higher prevalence of goitre but not thyroid nodules among the younger age groups in Malaysia: Results of a nationwide study into thyroid disorders

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