The prevalence of overt and subclinical thyroid disorders in the adult population of Malaysia

To determine the prevalence of thyroid dysfunction among the Malaysian adult population A cross sectional study involving 2259 subjects selected from 5 pre-assigned regions which were representative of the socioeconomic and geographical background in Malaysia was performed. Sixty-nine subjects were...

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Main Authors:	Shahar, Mohammad Arif, Omar, Ahmad Marzuki, Ab Wahab, Norasyikin, Sukor, Norlela, Kamaruddin, Nor Azmi
Format:	Article
Language:	English
Published:	Korean Thyroid Association 2017
Subjects:	R Medicine (General) RC Internal medicine
Online Access:	http://irep.iium.edu.my/58583/ http://irep.iium.edu.my/58583/ http://irep.iium.edu.my/58583/1/ITJ%20subclinical%20thyroid%20disorders.pdf

id	iium-58583
recordtype	eprints
spelling	iium-585832018-01-12T11:13:21Z http://irep.iium.edu.my/58583/ The prevalence of overt and subclinical thyroid disorders in the adult population of Malaysia Shahar, Mohammad Arif Omar, Ahmad Marzuki Ab Wahab, Norasyikin Sukor, Norlela Kamaruddin, Nor Azmi R Medicine (General) RC Internal medicine To determine the prevalence of thyroid dysfunction among the Malaysian adult population A cross sectional study involving 2259 subjects selected from 5 pre-assigned regions which were representative of the socioeconomic and geographical background in Malaysia was performed. Sixty-nine subjects were excluded due to incomplete data. The prevalence of thyroid dysfunction was also determined in 2054 subjects who did not report any history of thyroid diseases nor taking any thyroid medications (disease-free population). Hundred thirty-six (136) subjects with known thyroid disorders were analysed in detail. The hormonal assays and thyroid antibodies were performed using chemiluminescent microparticle immunoassays by the Architect and Immulite systems respectively. Overt and subclinical hypothyroidism were defined as TSH > 5.00uIU/mL with free thyroxine (T4) < 9.10pmol/L and fT4 within the reference range (9.10 - 23.80pmol./L) respectively. Overt and subclinical hyperthyroidism were defined as TSH < 0.32uIU/mL with fT4 > 23.80pmol/L and fT4 within the reference range respectively. The overall prevalence of overt hypothyroidism was 0.5%; subclinical hypothyroidism 1.6%; overt hyperthyroidism 0.6% and subclinical hyperthyroidism 2.8%. The prevalence of thyroid dysfunctions in the disease-free population were: overt hypothyroidism 0.3%; subclinical hypothyroidism 1.1% and subclinical hyperthyroidism 2.0%. Among those with history of thyroid disorders, 57.1% subjects on L-thyroxine and 48.0% subjects on anti-thyroid drugs were found to be euthyroid. Hyperthyroidism was associated with detectable antiTPO and antiTG. Female had a higher preponderance for thyroid dysfunction across all ages. There was however no significant difference in the prevalence of thyroid dysfunctions between various geographical locations (urban vs rural; coastal vs inland), age and ethnicity. The prevalence of overt hypothyroidism and hyperthyroidism in the adult population of Malaysia were 0.5% and 0.6% respectively with higher preponderance in females as observed in other studies. While the prevalence of the subclinical entities of both hypo and hyperthyroidism were 1.6% and 2.8% respectively. Korean Thyroid Association 2017 Article PeerReviewed application/pdf en http://irep.iium.edu.my/58583/1/ITJ%20subclinical%20thyroid%20disorders.pdf Shahar, Mohammad Arif and Omar, Ahmad Marzuki and Ab Wahab, Norasyikin and Sukor, Norlela and Kamaruddin, Nor Azmi (2017) The prevalence of overt and subclinical thyroid disorders in the adult population of Malaysia. International Journal of Thyroidology, 10 (Supplement 1). S177-S177. ISSN 2384-3799 E-ISSN 2466-1899 http://www.ijthyroid.org/main.html
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General) RC Internal medicine
spellingShingle	R Medicine (General) RC Internal medicine Shahar, Mohammad Arif Omar, Ahmad Marzuki Ab Wahab, Norasyikin Sukor, Norlela Kamaruddin, Nor Azmi The prevalence of overt and subclinical thyroid disorders in the adult population of Malaysia
description	To determine the prevalence of thyroid dysfunction among the Malaysian adult population A cross sectional study involving 2259 subjects selected from 5 pre-assigned regions which were representative of the socioeconomic and geographical background in Malaysia was performed. Sixty-nine subjects were excluded due to incomplete data. The prevalence of thyroid dysfunction was also determined in 2054 subjects who did not report any history of thyroid diseases nor taking any thyroid medications (disease-free population). Hundred thirty-six (136) subjects with known thyroid disorders were analysed in detail. The hormonal assays and thyroid antibodies were performed using chemiluminescent microparticle immunoassays by the Architect and Immulite systems respectively. Overt and subclinical hypothyroidism were defined as TSH > 5.00uIU/mL with free thyroxine (T4) < 9.10pmol/L and fT4 within the reference range (9.10 - 23.80pmol./L) respectively. Overt and subclinical hyperthyroidism were defined as TSH < 0.32uIU/mL with fT4 > 23.80pmol/L and fT4 within the reference range respectively. The overall prevalence of overt hypothyroidism was 0.5%; subclinical hypothyroidism 1.6%; overt hyperthyroidism 0.6% and subclinical hyperthyroidism 2.8%. The prevalence of thyroid dysfunctions in the disease-free population were: overt hypothyroidism 0.3%; subclinical hypothyroidism 1.1% and subclinical hyperthyroidism 2.0%. Among those with history of thyroid disorders, 57.1% subjects on L-thyroxine and 48.0% subjects on anti-thyroid drugs were found to be euthyroid. Hyperthyroidism was associated with detectable antiTPO and antiTG. Female had a higher preponderance for thyroid dysfunction across all ages. There was however no significant difference in the prevalence of thyroid dysfunctions between various geographical locations (urban vs rural; coastal vs inland), age and ethnicity. The prevalence of overt hypothyroidism and hyperthyroidism in the adult population of Malaysia were 0.5% and 0.6% respectively with higher preponderance in females as observed in other studies. While the prevalence of the subclinical entities of both hypo and hyperthyroidism were 1.6% and 2.8% respectively.
format	Article
author	Shahar, Mohammad Arif Omar, Ahmad Marzuki Ab Wahab, Norasyikin Sukor, Norlela Kamaruddin, Nor Azmi
author_facet	Shahar, Mohammad Arif Omar, Ahmad Marzuki Ab Wahab, Norasyikin Sukor, Norlela Kamaruddin, Nor Azmi
author_sort	Shahar, Mohammad Arif
title	The prevalence of overt and subclinical thyroid disorders in the adult population of Malaysia
title_short	The prevalence of overt and subclinical thyroid disorders in the adult population of Malaysia
title_full	The prevalence of overt and subclinical thyroid disorders in the adult population of Malaysia
title_fullStr	The prevalence of overt and subclinical thyroid disorders in the adult population of Malaysia
title_full_unstemmed	The prevalence of overt and subclinical thyroid disorders in the adult population of Malaysia
title_sort	prevalence of overt and subclinical thyroid disorders in the adult population of malaysia
publisher	Korean Thyroid Association
publishDate	2017
url	http://irep.iium.edu.my/58583/ http://irep.iium.edu.my/58583/ http://irep.iium.edu.my/58583/1/ITJ%20subclinical%20thyroid%20disorders.pdf
first_indexed	2023-09-18T21:22:52Z
last_indexed	2023-09-18T21:22:52Z
_version_	1777411998345068544

The prevalence of overt and subclinical thyroid disorders in the adult population of Malaysia

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