Ficus auriculata (fig) extracts induced cell cycle profile changes and apoptosis through caspase-independent pathway in human LungAdenocarcinoma cell line, A549

Ficus auriculata (fig) extracts induced cell cycle profile changes and apoptosis through caspase-independent pathway in human LungAdenocarcinoma cell line, A549

Background: Ficus auriculata (fig) has immense value of benefits with regards to their medicinal and therapeutic properties. It has been long used in traditional folk medicine, and one of the fruits mentioned in Al-Quran. Many scientific researches have proven the usage of this natural medicine i...

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Main Authors: Jamil, Elyna Fatini, Abdul Ghani, Radiah
Format: Article
Language:English
English
Published: Iranian Academic Center of Education, Culture and Research (A.C.E.C.R.) 2017
Subjects:
RB Pathology
RM Therapeutics. Pharmacology
Online Access:http://irep.iium.edu.my/58231/
http://irep.iium.edu.my/58231/
http://irep.iium.edu.my/58231/1/A-10-1491-2%20Dr%20radiah%20abdul%20%20ghani.pdf
http://irep.iium.edu.my/58231/7/58231_Ficus%20auriculata%20%28fig%29%20extracts%20induced%20cell%20cycle%20profile%20changes_SCOPUS.pdf
id iium-58231
recordtype eprints
spelling iium-582312018-04-25T08:54:35Z http://irep.iium.edu.my/58231/ Ficus auriculata (fig) extracts induced cell cycle profile changes and apoptosis through caspase-independent pathway in human LungAdenocarcinoma cell line, A549 Jamil, Elyna Fatini Abdul Ghani, Radiah RB Pathology RM Therapeutics. Pharmacology Background: Ficus auriculata (fig) has immense value of benefits with regards to their medicinal and therapeutic properties. It has been long used in traditional folk medicine, and one of the fruits mentioned in Al-Quran. Many scientific researches have proven the usage of this natural medicine in in vitro and in vivo studies, where anti-cancer is among of its recognized properties. Objective: To acquire further details on how F. auriculata (fig) inhibited cancer growth, we investigated the effects of its exposure on cell cycle profile. Methods: Subsequently we determined the type of cell death and the mechanism it induced using flow cytometer. Human lung adenocarcinoma cell line A549 was selected as the model of this study. Results: It is indicated significant decreased of A549 cells in G0/G1and concurrent accumulation of cells in G2/M phase. Cell death analysis revealed significant late apoptosis induced by F. auriculata (fig) via caspase independent pathway. Conclusion: Therefore, we concluded that F. auriculata (fig) is one of the promising natural medicines that can be used as cancer preventive strategy, as a result from its effects against cell cycle profile and apoptosis via caspase independent pathway. Iranian Academic Center of Education, Culture and Research (A.C.E.C.R.) 2017-09-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/58231/1/A-10-1491-2%20Dr%20radiah%20abdul%20%20ghani.pdf application/pdf en http://irep.iium.edu.my/58231/7/58231_Ficus%20auriculata%20%28fig%29%20extracts%20induced%20cell%20cycle%20profile%20changes_SCOPUS.pdf Jamil, Elyna Fatini and Abdul Ghani, Radiah (2017) Ficus auriculata (fig) extracts induced cell cycle profile changes and apoptosis through caspase-independent pathway in human LungAdenocarcinoma cell line, A549. Journal of Medicinal Plants, 3 (63 (Summer)). pp. 57-67. ISSN 1684-0240 http://jmp.ir/article-1-1831-en.html
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
English
topic RB Pathology
RM Therapeutics. Pharmacology
spellingShingle RB Pathology
RM Therapeutics. Pharmacology
Jamil, Elyna Fatini
Abdul Ghani, Radiah
Ficus auriculata (fig) extracts induced cell cycle profile changes and apoptosis through caspase-independent pathway in human LungAdenocarcinoma cell line, A549
description Background: Ficus auriculata (fig) has immense value of benefits with regards to their medicinal and therapeutic properties. It has been long used in traditional folk medicine, and one of the fruits mentioned in Al-Quran. Many scientific researches have proven the usage of this natural medicine in in vitro and in vivo studies, where anti-cancer is among of its recognized properties. Objective: To acquire further details on how F. auriculata (fig) inhibited cancer growth, we investigated the effects of its exposure on cell cycle profile. Methods: Subsequently we determined the type of cell death and the mechanism it induced using flow cytometer. Human lung adenocarcinoma cell line A549 was selected as the model of this study. Results: It is indicated significant decreased of A549 cells in G0/G1and concurrent accumulation of cells in G2/M phase. Cell death analysis revealed significant late apoptosis induced by F. auriculata (fig) via caspase independent pathway. Conclusion: Therefore, we concluded that F. auriculata (fig) is one of the promising natural medicines that can be used as cancer preventive strategy, as a result from its effects against cell cycle profile and apoptosis via caspase independent pathway.
format Article
author Jamil, Elyna Fatini
Abdul Ghani, Radiah
author_facet Jamil, Elyna Fatini
Abdul Ghani, Radiah
author_sort Jamil, Elyna Fatini
title Ficus auriculata (fig) extracts induced cell cycle profile changes and apoptosis through caspase-independent pathway in human LungAdenocarcinoma cell line, A549
title_short Ficus auriculata (fig) extracts induced cell cycle profile changes and apoptosis through caspase-independent pathway in human LungAdenocarcinoma cell line, A549
title_full Ficus auriculata (fig) extracts induced cell cycle profile changes and apoptosis through caspase-independent pathway in human LungAdenocarcinoma cell line, A549
title_fullStr Ficus auriculata (fig) extracts induced cell cycle profile changes and apoptosis through caspase-independent pathway in human LungAdenocarcinoma cell line, A549
title_full_unstemmed Ficus auriculata (fig) extracts induced cell cycle profile changes and apoptosis through caspase-independent pathway in human LungAdenocarcinoma cell line, A549
title_sort ficus auriculata (fig) extracts induced cell cycle profile changes and apoptosis through caspase-independent pathway in human lungadenocarcinoma cell line, a549
publisher Iranian Academic Center of Education, Culture and Research (A.C.E.C.R.)
publishDate 2017
url http://irep.iium.edu.my/58231/
http://irep.iium.edu.my/58231/
http://irep.iium.edu.my/58231/1/A-10-1491-2%20Dr%20radiah%20abdul%20%20ghani.pdf
http://irep.iium.edu.my/58231/7/58231_Ficus%20auriculata%20%28fig%29%20extracts%20induced%20cell%20cycle%20profile%20changes_SCOPUS.pdf
first_indexed 2023-09-18T21:22:19Z
last_indexed 2023-09-18T21:22:19Z
_version_ 1777411963945484288

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