The antidiabetic activity of curry leaves “Murraya koenigii” on the glucose levels, kidneys, and islets of langerhans of rats with streptozotocin induced diabetes

Background: The aims of this study were to explore the antihyperglycemic effect of curry leaves, Murraya koenigii “MK” aqueous extract, and to examine its possible protective effects on the islets of Langerhans and kidneys of streptozotocin (STZ) diabetic rats. Methods: Thirty healthy adult male Spr...

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Main Authors:	Al-Ani, Imad Matloub Dally, Santosa, Rahajoe Imam, Yankuzo, Muhammad H., Saxena, Anil Kumar, Alazzawi, Khalid S.
Format:	Article
Language:	English
Published:	Universitas Indonesia 2017
Subjects:	QM Human anatomy QP Physiology RB Pathology
Online Access:	http://irep.iium.edu.my/58182/ http://irep.iium.edu.my/58182/ http://irep.iium.edu.my/58182/ http://irep.iium.edu.my/58182/1/58182_The%20Antidiabetic%20Activity%20of%20Curry%20Leaves.pdf

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recordtype	eprints
spelling	iium-581822017-09-13T09:22:03Z http://irep.iium.edu.my/58182/ The antidiabetic activity of curry leaves “Murraya koenigii” on the glucose levels, kidneys, and islets of langerhans of rats with streptozotocin induced diabetes Al-Ani, Imad Matloub Dally Santosa, Rahajoe Imam Yankuzo, Muhammad H. Saxena, Anil Kumar Alazzawi, Khalid S. QM Human anatomy QP Physiology RB Pathology Background: The aims of this study were to explore the antihyperglycemic effect of curry leaves, Murraya koenigii “MK” aqueous extract, and to examine its possible protective effects on the islets of Langerhans and kidneys of streptozotocin (STZ) diabetic rats. Methods: Thirty healthy adult male Sprague Dawley rats were randomized into five groups (n=6); normal control, normal treated with “MK” control, diabetic control (non-treated with “MK”), diabetic treated with 200 mg/kg MK aqueous leaf extract and diabetic treated with 400 mg/kg MK aqueous leaf extract. Blood glucose levels and body weight were monitored gravimetrically. The animals were sacrificed on the 30th day; the kidney and pancreatic tissues were processed for histological studies. Results: The diabetic group showed considerable loss of body weight and increase in blood glucose levels and degeneration of the glomeruli and renal convoluted tubules and atrophied islets with disintegration of β-cells. Treatment of diabetic rats with MK extract showed significant (p < 0.001) improvement in blood glucose levels and body weight gain. The MK extract also caused an improvement in tissue injury induced by STZ injection in the kidney and islets of Langerhans. Conclusions: These findings highlighted the beneficial effects of MK aqueous extract against cellular oxidative damage in STZ-induced diabetic rats. Universitas Indonesia 2017-08 Article PeerReviewed application/pdf en http://irep.iium.edu.my/58182/1/58182_The%20Antidiabetic%20Activity%20of%20Curry%20Leaves.pdf Al-Ani, Imad Matloub Dally and Santosa, Rahajoe Imam and Yankuzo, Muhammad H. and Saxena, Anil Kumar and Alazzawi, Khalid S. (2017) The antidiabetic activity of curry leaves “Murraya koenigii” on the glucose levels, kidneys, and islets of langerhans of rats with streptozotocin induced diabetes. Makara Journal of Health Research (MJHR), 21 (2). 54 -60. ISSN 2356-3664 E-ISSN 2356-3656 http://journal.ui.ac.id/index.php/health/article/view/7393/3933 10.7454/msk.v21i2.7393
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QM Human anatomy QP Physiology RB Pathology
spellingShingle	QM Human anatomy QP Physiology RB Pathology Al-Ani, Imad Matloub Dally Santosa, Rahajoe Imam Yankuzo, Muhammad H. Saxena, Anil Kumar Alazzawi, Khalid S. The antidiabetic activity of curry leaves “Murraya koenigii” on the glucose levels, kidneys, and islets of langerhans of rats with streptozotocin induced diabetes
description	Background: The aims of this study were to explore the antihyperglycemic effect of curry leaves, Murraya koenigii “MK” aqueous extract, and to examine its possible protective effects on the islets of Langerhans and kidneys of streptozotocin (STZ) diabetic rats. Methods: Thirty healthy adult male Sprague Dawley rats were randomized into five groups (n=6); normal control, normal treated with “MK” control, diabetic control (non-treated with “MK”), diabetic treated with 200 mg/kg MK aqueous leaf extract and diabetic treated with 400 mg/kg MK aqueous leaf extract. Blood glucose levels and body weight were monitored gravimetrically. The animals were sacrificed on the 30th day; the kidney and pancreatic tissues were processed for histological studies. Results: The diabetic group showed considerable loss of body weight and increase in blood glucose levels and degeneration of the glomeruli and renal convoluted tubules and atrophied islets with disintegration of β-cells. Treatment of diabetic rats with MK extract showed significant (p < 0.001) improvement in blood glucose levels and body weight gain. The MK extract also caused an improvement in tissue injury induced by STZ injection in the kidney and islets of Langerhans. Conclusions: These findings highlighted the beneficial effects of MK aqueous extract against cellular oxidative damage in STZ-induced diabetic rats.
format	Article
author	Al-Ani, Imad Matloub Dally Santosa, Rahajoe Imam Yankuzo, Muhammad H. Saxena, Anil Kumar Alazzawi, Khalid S.
author_facet	Al-Ani, Imad Matloub Dally Santosa, Rahajoe Imam Yankuzo, Muhammad H. Saxena, Anil Kumar Alazzawi, Khalid S.
author_sort	Al-Ani, Imad Matloub Dally
title	The antidiabetic activity of curry leaves “Murraya koenigii” on the glucose levels, kidneys, and islets of langerhans of rats with streptozotocin induced diabetes
title_short	The antidiabetic activity of curry leaves “Murraya koenigii” on the glucose levels, kidneys, and islets of langerhans of rats with streptozotocin induced diabetes
title_full	The antidiabetic activity of curry leaves “Murraya koenigii” on the glucose levels, kidneys, and islets of langerhans of rats with streptozotocin induced diabetes
title_fullStr	The antidiabetic activity of curry leaves “Murraya koenigii” on the glucose levels, kidneys, and islets of langerhans of rats with streptozotocin induced diabetes
title_full_unstemmed	The antidiabetic activity of curry leaves “Murraya koenigii” on the glucose levels, kidneys, and islets of langerhans of rats with streptozotocin induced diabetes
title_sort	antidiabetic activity of curry leaves “murraya koenigii” on the glucose levels, kidneys, and islets of langerhans of rats with streptozotocin induced diabetes
publisher	Universitas Indonesia
publishDate	2017
url	http://irep.iium.edu.my/58182/ http://irep.iium.edu.my/58182/ http://irep.iium.edu.my/58182/ http://irep.iium.edu.my/58182/1/58182_The%20Antidiabetic%20Activity%20of%20Curry%20Leaves.pdf
first_indexed	2023-09-18T21:22:15Z
last_indexed	2023-09-18T21:22:15Z
_version_	1777411959413538816

The antidiabetic activity of curry leaves “Murraya koenigii” on the glucose levels, kidneys, and islets of langerhans of rats with streptozotocin induced diabetes

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