Estimation of plasma insulin and endogenous insulin secretion in critically ill patients using intensive control insulin-nutrition-glucose model

The objective of this study is to estimate total plasma insulin level and endogenous insulin secretion by using Intensive Control Insulin-Nutrition-Glucose (ICING) model and 90 critically ill patients’ data from Hospital Tengku Ampuan Afzan, Kuantan. Integral-based method was applied to solve mathem...

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Main Authors:	Jamaludin, Ummu Kulthum, Suhaimi, Fatanah M., Abdul Razak, Normy Norfiza, Md Ralib, Azrina, Mat Nor, Mohd Basri
Format:	Article
Language:	English English English
Published:	American Scientific Publishers 2017
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/58152/ http://irep.iium.edu.my/58152/ http://irep.iium.edu.my/58152/1/I4CT%20Estimation%20of%20Plasma%20Insulin%20and%20Endogenous%20Insulin%20Secretion%20in%20Critically%20Ill%20Patients%20using%20ICING%20Model.pdf http://irep.iium.edu.my/58152/7/58152_Estimation%20of%20Plasma%20Insulin_MYRA.pdf http://irep.iium.edu.my/58152/13/Estimation%20of%20plasma%20insulin%20and%20endogenous%20insulin%20secretion%20in%20critically%20III%20patients%20using%20intensive%20control%20insulin-nutrition-glucose%20model.pdf

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spelling	iium-581522018-03-20T05:16:18Z http://irep.iium.edu.my/58152/ Estimation of plasma insulin and endogenous insulin secretion in critically ill patients using intensive control insulin-nutrition-glucose model Jamaludin, Ummu Kulthum Suhaimi, Fatanah M. Abdul Razak, Normy Norfiza Md Ralib, Azrina Mat Nor, Mohd Basri R Medicine (General) The objective of this study is to estimate total plasma insulin level and endogenous insulin secretion by using Intensive Control Insulin-Nutrition-Glucose (ICING) model and 90 critically ill patients’ data from Hospital Tengku Ampuan Afzan, Kuantan. Integral-based method was applied to solve mathematical equations defined in ICING model to find critical parameters of insulin sensitivity (SI) and results of total endogenous insulin secretion and total plasma insulin level were presented in median and 95% confidence interval (CI). It is reported that the total median plasma insulin is 1.35 × 106 mU while (6.59 × 105, 2.79 × 106) mU is in 95% CI, and the total median endogenous insulin secretion is 12.9% from the total median plasma insulin. The results elucidated the effectiveness of current practice via Intensive Insulin Infusion Therapy (IIT) and also suggest a further study on investigating the incretin mechanism which is strongly believed to contribute to the total plasma insulin level and help to simulate endogenous insulin secretion. American Scientific Publishers 2017-08-01 Article NonPeerReviewed application/pdf en http://irep.iium.edu.my/58152/1/I4CT%20Estimation%20of%20Plasma%20Insulin%20and%20Endogenous%20Insulin%20Secretion%20in%20Critically%20Ill%20Patients%20using%20ICING%20Model.pdf application/pdf en http://irep.iium.edu.my/58152/7/58152_Estimation%20of%20Plasma%20Insulin_MYRA.pdf application/pdf en http://irep.iium.edu.my/58152/13/Estimation%20of%20plasma%20insulin%20and%20endogenous%20insulin%20secretion%20in%20critically%20III%20patients%20using%20intensive%20control%20insulin-nutrition-glucose%20model.pdf Jamaludin, Ummu Kulthum and Suhaimi, Fatanah M. and Abdul Razak, Normy Norfiza and Md Ralib, Azrina and Mat Nor, Mohd Basri (2017) Estimation of plasma insulin and endogenous insulin secretion in critically ill patients using intensive control insulin-nutrition-glucose model. Advanced Science Letters, 23 (6). pp. 5510-5514. ISSN 1936-6612 E-ISSN 1936-7317 http://www.aspbs.com/science/contents-science2017.htm#236
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Jamaludin, Ummu Kulthum Suhaimi, Fatanah M. Abdul Razak, Normy Norfiza Md Ralib, Azrina Mat Nor, Mohd Basri Estimation of plasma insulin and endogenous insulin secretion in critically ill patients using intensive control insulin-nutrition-glucose model
description	The objective of this study is to estimate total plasma insulin level and endogenous insulin secretion by using Intensive Control Insulin-Nutrition-Glucose (ICING) model and 90 critically ill patients’ data from Hospital Tengku Ampuan Afzan, Kuantan. Integral-based method was applied to solve mathematical equations defined in ICING model to find critical parameters of insulin sensitivity (SI) and results of total endogenous insulin secretion and total plasma insulin level were presented in median and 95% confidence interval (CI). It is reported that the total median plasma insulin is 1.35 × 106 mU while (6.59 × 105, 2.79 × 106) mU is in 95% CI, and the total median endogenous insulin secretion is 12.9% from the total median plasma insulin. The results elucidated the effectiveness of current practice via Intensive Insulin Infusion Therapy (IIT) and also suggest a further study on investigating the incretin mechanism which is strongly believed to contribute to the total plasma insulin level and help to simulate endogenous insulin secretion.
format	Article
author	Jamaludin, Ummu Kulthum Suhaimi, Fatanah M. Abdul Razak, Normy Norfiza Md Ralib, Azrina Mat Nor, Mohd Basri
author_facet	Jamaludin, Ummu Kulthum Suhaimi, Fatanah M. Abdul Razak, Normy Norfiza Md Ralib, Azrina Mat Nor, Mohd Basri
author_sort	Jamaludin, Ummu Kulthum
title	Estimation of plasma insulin and endogenous insulin secretion in critically ill patients using intensive control insulin-nutrition-glucose model
title_short	Estimation of plasma insulin and endogenous insulin secretion in critically ill patients using intensive control insulin-nutrition-glucose model
title_full	Estimation of plasma insulin and endogenous insulin secretion in critically ill patients using intensive control insulin-nutrition-glucose model
title_fullStr	Estimation of plasma insulin and endogenous insulin secretion in critically ill patients using intensive control insulin-nutrition-glucose model
title_full_unstemmed	Estimation of plasma insulin and endogenous insulin secretion in critically ill patients using intensive control insulin-nutrition-glucose model
title_sort	estimation of plasma insulin and endogenous insulin secretion in critically ill patients using intensive control insulin-nutrition-glucose model
publisher	American Scientific Publishers
publishDate	2017
url	http://irep.iium.edu.my/58152/ http://irep.iium.edu.my/58152/ http://irep.iium.edu.my/58152/1/I4CT%20Estimation%20of%20Plasma%20Insulin%20and%20Endogenous%20Insulin%20Secretion%20in%20Critically%20Ill%20Patients%20using%20ICING%20Model.pdf http://irep.iium.edu.my/58152/7/58152_Estimation%20of%20Plasma%20Insulin_MYRA.pdf http://irep.iium.edu.my/58152/13/Estimation%20of%20plasma%20insulin%20and%20endogenous%20insulin%20secretion%20in%20critically%20III%20patients%20using%20intensive%20control%20insulin-nutrition-glucose%20model.pdf
first_indexed	2023-09-18T21:22:12Z
last_indexed	2023-09-18T21:22:12Z
_version_	1777411956628520960

Estimation of plasma insulin and endogenous insulin secretion in critically ill patients using intensive control insulin-nutrition-glucose model

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