Synthesize and characterization of putrescine sulfur analogues

Synthesize and characterization of putrescine sulfur analogues

Cancer is a disease which has high motility rate worldwide. The current treatment has a high potential to kill cancer cells, however it is lacking of specificity and therefore cause the side effects in normal cells. The alternate pathway has been explored including targeting to cancer cells via pol...

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Main Authors: Sahabudin, Adzly Hairee, How, Fiona Ni Foong, Abdul Ghani, Radiah
Format: Article
Language:English
Published: Universiti Teknologi MARA Cawangan Pulau Pinang 2017
Subjects:
QD Chemistry
RM Therapeutics. Pharmacology
Online Access:http://irep.iium.edu.my/58120/
http://irep.iium.edu.my/58120/
http://irep.iium.edu.my/58120/1/ARTICLE%20ESTEEM%20JOURNAL.pdf
id iium-58120
recordtype eprints
spelling iium-581202017-08-22T08:00:25Z http://irep.iium.edu.my/58120/ Synthesize and characterization of putrescine sulfur analogues Sahabudin, Adzly Hairee How, Fiona Ni Foong Abdul Ghani, Radiah QD Chemistry RM Therapeutics. Pharmacology Cancer is a disease which has high motility rate worldwide. The current treatment has a high potential to kill cancer cells, however it is lacking of specificity and therefore cause the side effects in normal cells. The alternate pathway has been explored including targeting to cancer cells via polyamine transport system (PTS). The PTS activity is highly upregulated in cancer cells compared to normal cells. In this study, one of the polyamines called putrescine was being exploited to be a vector for sulphur. This putrescinesulphur analogues were synthesized using two different methods. The synthesized product was later characterized using various physicochemical techniques such as gas-chromatography and Fourier transformed-infrared spectroscopy for structural determination. Several putrescine-sulphur analogue was succesfully synthesis with the expected structures. Universiti Teknologi MARA Cawangan Pulau Pinang 2017-08 Article PeerReviewed application/pdf en http://irep.iium.edu.my/58120/1/ARTICLE%20ESTEEM%20JOURNAL.pdf Sahabudin, Adzly Hairee and How, Fiona Ni Foong and Abdul Ghani, Radiah (2017) Synthesize and characterization of putrescine sulfur analogues. ESTEEM Academic Journal, 13 (Special Issue). pp. 91-97. ISSN 1675-7939 E-ISSN 2289-4934 http://uppp.uitm.edu.my/images/doc/ESTEEM_pdf_format/vol13specialaugust/orc120.pdf
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic QD Chemistry
RM Therapeutics. Pharmacology
spellingShingle QD Chemistry
RM Therapeutics. Pharmacology
Sahabudin, Adzly Hairee
How, Fiona Ni Foong
Abdul Ghani, Radiah
Synthesize and characterization of putrescine sulfur analogues
description Cancer is a disease which has high motility rate worldwide. The current treatment has a high potential to kill cancer cells, however it is lacking of specificity and therefore cause the side effects in normal cells. The alternate pathway has been explored including targeting to cancer cells via polyamine transport system (PTS). The PTS activity is highly upregulated in cancer cells compared to normal cells. In this study, one of the polyamines called putrescine was being exploited to be a vector for sulphur. This putrescinesulphur analogues were synthesized using two different methods. The synthesized product was later characterized using various physicochemical techniques such as gas-chromatography and Fourier transformed-infrared spectroscopy for structural determination. Several putrescine-sulphur analogue was succesfully synthesis with the expected structures.
format Article
author Sahabudin, Adzly Hairee
How, Fiona Ni Foong
Abdul Ghani, Radiah
author_facet Sahabudin, Adzly Hairee
How, Fiona Ni Foong
Abdul Ghani, Radiah
author_sort Sahabudin, Adzly Hairee
title Synthesize and characterization of putrescine sulfur analogues
title_short Synthesize and characterization of putrescine sulfur analogues
title_full Synthesize and characterization of putrescine sulfur analogues
title_fullStr Synthesize and characterization of putrescine sulfur analogues
title_full_unstemmed Synthesize and characterization of putrescine sulfur analogues
title_sort synthesize and characterization of putrescine sulfur analogues
publisher Universiti Teknologi MARA Cawangan Pulau Pinang
publishDate 2017
url http://irep.iium.edu.my/58120/
http://irep.iium.edu.my/58120/
http://irep.iium.edu.my/58120/1/ARTICLE%20ESTEEM%20JOURNAL.pdf
first_indexed 2023-09-18T21:22:09Z
last_indexed 2023-09-18T21:22:09Z
_version_ 1777411953497473024

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