Preliminary in vivo evaluation of bone healing in critical size bone defects implanted with an injectable calcium-phosphate bone cement (Osteopaste)

Introduction: A novel of injectable calcium phosphate bone cement (osteopaste) has been developed. Its potential application in Orthopaedics as a filler of bone defects has been studied. The biomaterial was composed of tetra-calcium phosphate (TTCP) and tri-calcium phosphate (TCP) powder. The aim of...

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Main Authors:	Che Seman, Che Nor Zarida, Zakaria@Mohamad, Zamzuri, Buyong, Zunariah, Awang, Mohd Shukrimi, Md Ralib @ Md Raghib, Ahmad Razali
Format:	Conference or Workshop Item
Language:	English
Published:	2017
Subjects:	QM Human anatomy R Medicine (General)
Online Access:	http://irep.iium.edu.my/58050/ http://irep.iium.edu.my/58050/ http://irep.iium.edu.my/58050/1/Abstract%20-%20MRS%202017.pdf

id	iium-58050
recordtype	eprints
spelling	iium-580502017-08-21T02:49:19Z http://irep.iium.edu.my/58050/ Preliminary in vivo evaluation of bone healing in critical size bone defects implanted with an injectable calcium-phosphate bone cement (Osteopaste) Che Seman, Che Nor Zarida Zakaria@Mohamad, Zamzuri Buyong, Zunariah Awang, Mohd Shukrimi Md Ralib @ Md Raghib, Ahmad Razali QM Human anatomy R Medicine (General) Introduction: A novel of injectable calcium phosphate bone cement (osteopaste) has been developed. Its potential application in Orthopaedics as a filler of bone defects has been studied. The biomaterial was composed of tetra-calcium phosphate (TTCP) and tri-calcium phosphate (TCP) powder. The aim of the present study was to evaluate the healing process of osteopaste in rabbit tibia. Materials and method: The implantation procedure was carried out on thirty-nine of New Zealand white rabbits. The in vivo bone formation was investigated by either implanting the Osteopaste, Jectos or MIIG – X3 into a critical size defect (CSD) model in the proximal tibial metaphysis. CSD without treatment served as negative control. After 1 day, 6 and 12 weeks, the rabbits were euthanized, the bone were harvested and subjected for analysis. Results: Radiological images and histological sections revealed integration of implants with bone tissue with no signs of graft rejection. There was direct contact between osteopaste material and host bone. The new bone was seen bridging the defect. Conclusion: The result showed that Osteopaste could become a new promising biomaterial for bone repair and has a potential in bone tissue engineering. 2017-08-09 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/58050/1/Abstract%20-%20MRS%202017.pdf Che Seman, Che Nor Zarida and Zakaria@Mohamad, Zamzuri and Buyong, Zunariah and Awang, Mohd Shukrimi and Md Ralib @ Md Raghib, Ahmad Razali (2017) Preliminary in vivo evaluation of bone healing in critical size bone defects implanted with an injectable calcium-phosphate bone cement (Osteopaste). In: Medical Research Symposium 2017, 9th August 2017, Kuantan, Pahang. http://www.iium.edu.my/medicine/news/medical-research-symposium-mrs-2017
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QM Human anatomy R Medicine (General)
spellingShingle	QM Human anatomy R Medicine (General) Che Seman, Che Nor Zarida Zakaria@Mohamad, Zamzuri Buyong, Zunariah Awang, Mohd Shukrimi Md Ralib @ Md Raghib, Ahmad Razali Preliminary in vivo evaluation of bone healing in critical size bone defects implanted with an injectable calcium-phosphate bone cement (Osteopaste)
description	Introduction: A novel of injectable calcium phosphate bone cement (osteopaste) has been developed. Its potential application in Orthopaedics as a filler of bone defects has been studied. The biomaterial was composed of tetra-calcium phosphate (TTCP) and tri-calcium phosphate (TCP) powder. The aim of the present study was to evaluate the healing process of osteopaste in rabbit tibia. Materials and method: The implantation procedure was carried out on thirty-nine of New Zealand white rabbits. The in vivo bone formation was investigated by either implanting the Osteopaste, Jectos or MIIG – X3 into a critical size defect (CSD) model in the proximal tibial metaphysis. CSD without treatment served as negative control. After 1 day, 6 and 12 weeks, the rabbits were euthanized, the bone were harvested and subjected for analysis. Results: Radiological images and histological sections revealed integration of implants with bone tissue with no signs of graft rejection. There was direct contact between osteopaste material and host bone. The new bone was seen bridging the defect. Conclusion: The result showed that Osteopaste could become a new promising biomaterial for bone repair and has a potential in bone tissue engineering.
format	Conference or Workshop Item
author	Che Seman, Che Nor Zarida Zakaria@Mohamad, Zamzuri Buyong, Zunariah Awang, Mohd Shukrimi Md Ralib @ Md Raghib, Ahmad Razali
author_facet	Che Seman, Che Nor Zarida Zakaria@Mohamad, Zamzuri Buyong, Zunariah Awang, Mohd Shukrimi Md Ralib @ Md Raghib, Ahmad Razali
author_sort	Che Seman, Che Nor Zarida
title	Preliminary in vivo evaluation of bone healing in critical size bone defects implanted with an injectable calcium-phosphate bone cement (Osteopaste)
title_short	Preliminary in vivo evaluation of bone healing in critical size bone defects implanted with an injectable calcium-phosphate bone cement (Osteopaste)
title_full	Preliminary in vivo evaluation of bone healing in critical size bone defects implanted with an injectable calcium-phosphate bone cement (Osteopaste)
title_fullStr	Preliminary in vivo evaluation of bone healing in critical size bone defects implanted with an injectable calcium-phosphate bone cement (Osteopaste)
title_full_unstemmed	Preliminary in vivo evaluation of bone healing in critical size bone defects implanted with an injectable calcium-phosphate bone cement (Osteopaste)
title_sort	preliminary in vivo evaluation of bone healing in critical size bone defects implanted with an injectable calcium-phosphate bone cement (osteopaste)
publishDate	2017
url	http://irep.iium.edu.my/58050/ http://irep.iium.edu.my/58050/ http://irep.iium.edu.my/58050/1/Abstract%20-%20MRS%202017.pdf
first_indexed	2023-09-18T21:22:04Z
last_indexed	2023-09-18T21:22:04Z
_version_	1777411948502056960

Preliminary in vivo evaluation of bone healing in critical size bone defects implanted with an injectable calcium-phosphate bone cement (Osteopaste)

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